p-Toluenesulfonic acid monohydrate

Product Name: p-Toluenesulfonic acid monohydrate
CAS No.: 6192-52-5
Chemical Name: p-Toluenesulfonic acid monohydrate
Synonyms: PTSA;TOLUENE-4-SULFONIC ACID;PTX;PTSA.H2O;4-Methylbenzenesulfonic acid hydrate;TOLUENESULFONIC ACID MONOHYDRATE;PARA TOLUENE SULFONIC ACID;p-Toluenesulfonic acid hydrate;4-TOLUENESULFONIC ACID MONOHYDRATE;PTSA Monohydrate
CBNumber: CB3173385
Molecular Formula: C7H10O4S
Formula Weight: 190.22
MOL File: 6192-52-5.mol

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p-Toluenesulfonic acid monohydrate Property

Melting point:: 96-99 °C(lit.)
Boiling point:: 140°C 20mm
Density: 1,24 g/cm³
vapor density: 5.9 (vs air)
refractive index: 1,382-1,384
Flash point:: 180 °C
storage temp.: Store at +5°C to +30°C.
solubility: H₂O: 0.1 g/mL, clear
form: Solid
Colour Index: 42655
color: White to pink
PH: 1 (650g/l, H2O, 20℃)(anhydrous substance)
Water Solubility: soluble
Sensitive: Hygroscopic
Merck: 14,9533
BRN: 3568023
Stability:: Stable. Incompatible with strong oxidizing agents, strong bases, most common metals. Protect from moisture.
InChIKey: KJIFKLIQANRMOU-UHFFFAOYSA-N
CAS DataBase Reference: 6192-52-5(CAS DataBase Reference)
EPA Substance Registry System: Benzenesulfonic acid, 4-methyl-, monohydrate (6192-52-5)

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Safety

Hazard Codes: Xi,C
Risk Statements: 36/37/38-34-37
Safety Statements: 26-37-45-36/37/39
RIDADR: UN 2585 8/PG 3
WGK Germany: -
RTECS: XT6300000
F: 3
Autoignition Temperature: 600 °C
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29041000
Toxicity: LD50 orally in Rabbit: 2570 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: TX0770
Product name: p-Toluenesulfonic Acid, Monohydrate
Purity: GR ACS
Packaging: 500g
Price: $150
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.14725
Product name: Toluene-4-sulfonic acid monohydrate
Purity: for synthesis
Packaging: 100g
Price: $28.6
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.14725
Product name: Toluene-4-sulfonic acid monohydrate
Purity: for synthesis
Packaging: 1kg
Price: $75
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.14725
Product name: Toluene-4-sulfonic acid monohydrate
Purity: for synthesis
Packaging: 5kg
Price: $264
Updated: 2024/03/01

Sigma-Aldrich

Product number: 27815
Product name: p-Toluenesulfonic acid monohydrate
Purity: ≥99% (calc. to H2O free subst.)
Packaging: 1kg
Price: $62.5
Updated: 2024/03/01

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p-Toluenesulfonic acid monohydrate Chemical Properties,Usage,Production

Chemical Properties

White crystals

Uses

Derivitizing agent.

Uses

p-Toluenesulfonic acid monohydrate is used as a catalyst in the synthesis of resveratrol, in oxane derivatives as an antimalarial agent, as substituted piperidine and unsymmetrical benzyl. It acts as a catalyst in the preparation of 1,3,5-trisubstituted pyrazoles derivatives, selenated ketene dithioacetals, triazoloquinazolinone and benzimidazoquinazolinone derivatives. It also serves as an intermediate in the esterification and in reductive amination reactions.

Uses

p-Toluenesulfonic acid monohydrate (p-TsOH·H₂O) may be used as a catalyst in the synthesis of the following:

Unsymmetrical benzils.
Highly substituted piperidines.
1,3,5-Trisubstituted benzenes by trimerization of alkynes.
Triazoloquinazolinone and benzimidazoquinazolinone derivatives.
1,3,5-Trisubstituted pyrazoles derivatives.
Selenated ketene dithioacetals.

General Description

p-Toluenesulfonic acid monohydrate, an oxonium salt, is an inexpensive and easy to handle organic catalyst used in organic synthesis. The study of its crystalline structure shows that it is monoclinic with P2₁/c space group. Its solubility in aqueous sulfuric acid solutions has been studied.

Purification Methods

Purify the acid by precipitation from a saturated solution at 0o by introducing HCl gas. It can also be crystallised from conc HCl, then crystallised from dilute HCl (charcoal) to remove benzenesulfonic acid. It has been crystallised from EtOH/water. Dry it in a vacuum desiccator over solid KOH and CaCl2. p-Toluenesulfonic acid can be dehydrated by azeotropic distillation with *benzene or by heating at 100o for 4hours under water-pump vacuum. The anhydrous acid can be crystallised from *benzene, CHCl3, ethyl acetate, anhydrous MeOH, or from acetone by adding a large excess of *benzene. It can also be dried under vacuum at 50o. The S-benzylisothiuronium salt has m 182o (from aqueous EtOH). [Beilstein 11 IV 241.]

p-Toluenesulfonic acid monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

4-[4-(BROMOMETHYL)PHENYL]-1,2,3-THIADIAZOLE Pyridinium p-Toluenesulfonate Methyl glycolate Ethyl (R)-2-hydroxy-4-phenylbutyrate Saquinavir LENAMPICILLIN 2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ACETIC ACID Clemizole Doxifluridine 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Cefoperazone 4-[4-(TRIFLUOROMETHYL)PHENYL]-1,2,3-THIADIAZOL-5-AMINE 4-PYRIDINEETHANETHIOL HYDROCHLORIDE 4-(4-METHOXYPHENYL)-1,2,3-THIADIAZOL-5-AMINE 4-(1,2,3-THIADIAZOL-4-YL)BENZYLAMINE HYDROCHLORIDE 2-(3-CHLOROPROPYL)-1,3-DIOXOLANE METHYL 4-BROMO-3-OXOPENTANOATE 3-METHOXYCARBONYL-3-SULFOLENE 2-AMINO-4-METHYL-PYRIMIDINE-5-CARBOXYLIC ACID 4-CHLORO-2-(TETRAHYDRO-2H-PYRAN-2-YL)-5-HYDROXYPYRIDAZIN-3(2H)-ONE 4-(4-CHLOROPHENYL)-1,2,3-THIADIAZOL-5-AMINE 2-Phenyl-2-imidazoline

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p-Toluenesulfonic acid monohydrate Suppliers

Belgium 5 Canada 2 China 409 Czech Republic 3 Europe 3 France 4 Germany 13 Hungary 1 India 73 Japan 10 Malaysia 1 Poland 1 Russia 2 Slovakia 1 Spain 2 Switzerland 4 The Netherlands 1 United Kingdom 19 United States 78 Global 632

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View Lastest Price from p-Toluenesulfonic acid monohydrate manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Product: p-Toluenesulfonic acid monohydrate 6192-52-5
Price: US $100.00-75.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000Ton
Release date: 2024-08-13

HebeiShuoshengImportandExportco.,Ltd

Product: p-Toluenesulfonic acid monohydrate 6192-52-5
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-05

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: p-Toluenesulfonic acid monohydrate 6192-52-5
Price: US $100.00-45.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-06

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