5-Methoxy-3-indolecarboxylic acid
- Product Name
- 5-Methoxy-3-indolecarboxylic acid
- CAS No.
- 10242-01-0
- Chemical Name
- 5-Methoxy-3-indolecarboxylic acid
- Synonyms
- RARECHEM AL BE 0096;5-METHOXY-3-CARBOXYINDOLE;5-METHOXYINDOLE-3-CARBOXYLIC ACID;5-METHOXY-3-INDOLECARBOXYLIC ACID;5-Methoxy-1H-indol-3-carboxylic acid;5-Methoxyindole-3-carboxylicacid,97%;5-METHOXY-1H-INDOLE-3-CARBOXYLIC ACID;1H-Indole-3-carboxylic acid, 5-methoxy-;5-Methoxy-1H-indole-3-carboxylic acid 98%;5-Methoxyindole-3-carboxylic Acid Hydrate
- CBNumber
- CB3184224
- Molecular Formula
- C10H9NO3
- Formula Weight
- 191.18
- MOL File
- 10242-01-0.mol
5-Methoxy-3-indolecarboxylic acid Property
- Melting point:
- 172-175 °C
- Boiling point:
- 447.6±25.0 °C(Predicted)
- Density
- 1.381±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Crystalline
- pka
- 3.95±0.30(Predicted)
- color
- Red
- CAS DataBase Reference
- 10242-01-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- M2438
- Product name
- 5-Methoxyindole-3-carboxylic Acid Hydrate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $70
- Updated
- 2025/07/31
- Product number
- M2438
- Product name
- 5-Methoxyindole-3-carboxylic Acid Hydrate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $236
- Updated
- 2025/07/31
- Product number
- M263463
- Product name
- 5-Methoxyindole-3-carboxylicacid
- Packaging
- 50mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- X8613
- Product name
- 5-Methoxy-1H-indole-3-carboxylicacid
- Packaging
- 1g
- Price
- $99
- Updated
- 2021/12/16
- Product number
- 033217
- Product name
- 5-Methoxy-1H-indole-3-carboxylic acid
- Packaging
- 1g
- Price
- $247
- Updated
- 2021/12/16
5-Methoxy-3-indolecarboxylic acid Chemical Properties,Usage,Production
Uses
5-Methoxyindole-3-carboxylic Acid can be used in the synthesis of benzoheterocycle derivatives as vascular endothelial growth factor receptor-2 tyrosine kinase inhibitors and in the synthesis of indoleamine 2,3-dioxygenase 1 inhibitors with potential antitumor activity.
Synthesis
1006-94-6
124-38-9
10242-01-0
The general procedure for the synthesis of 5-methoxy-1H-indole-3-carboxylic acid from 5-methoxyindole and carbon dioxide was as follows: lithium tert-butoxide (LiOtBu, 160 mg, 2.00 mmol) and 5-methoxyindole (1a, 23.4 mg, 0.4 mmol) were added to a dry two-necked test tube. The reaction vessel was evacuated under high vacuum and the reaction atmosphere was replaced with a carbon dioxide balloon. Subsequently, N,N-dimethylformamide (DMF, 2 mL) was added and the mixture was stirred at 100 °C for 24 h of reaction. Upon completion of the reaction, the mixture was cooled to room temperature, the reaction was carefully quenched with 2N hydrochloric acid (HCl) solution and extracted with ethyl acetate (EtOAc, 5 times). The organic layers were combined, washed sequentially with water (2 times) and saturated brine (1 time) and dried over anhydrous magnesium sulfate (MgSO4). The dried organic phase was concentrated under reduced pressure and the residue was purified by preparative thin layer chromatography (TLC, unfolding reagent ratio of petroleum ether: acetone = 1:1) to afford the target product 5-methoxy-1H-indole-3-carboxylic acid (2a, 153.0 mg, 95% yield) as a white solid.
References
[1] Organic Letters, 2012, vol. 14, # 20, p. 5326 - 5329,4
[2] Heterocycles, 2015, vol. 90, # 2, p. 1196 - 1204
5-Methoxy-3-indolecarboxylic acid Preparation Products And Raw materials
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View Lastest Price from 5-Methoxy-3-indolecarboxylic acid manufacturers
- Product
- 5-Methoxy-3-indolecarboxylic acid 10242-01-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2019-12-18