4-Hydroxymethyl-4-methylpiperidine
- Product Name
- 4-Hydroxymethyl-4-methylpiperidine
- CAS No.
- 297172-16-8
- Chemical Name
- 4-Hydroxymethyl-4-methylpiperidine
- Synonyms
- 4-HydroxyMethyl-4-Methylp...;4-methyl-4-Piperidinemethanol;(4-methyl-4-piperidyl)methanol;4-Piperidinemethanol, 4-methyl-;(4-Methylpiperidin-4-yl)methanol;4-Hydroxymethyl-4-methylpiperidine;(4-Methylpiperidin-4-yl)methanol hcl;(4-Methylpiperidin-4-yl)Methanol hydrochloride;(4-methyl-4-piperidinyl)methanol(SALTDATA: HCl)
- CBNumber
- CB32105823
- Molecular Formula
- C7H15NO
- Formula Weight
- 129.2
- MOL File
- 297172-16-8.mol
4-Hydroxymethyl-4-methylpiperidine Property
- Boiling point:
- 200.8±13.0℃ (760 Torr)
- Density
- 0.926±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 76.7±10.5℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 14.94±0.10(Predicted)
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M725943
- Product name
- (4-Methylpiperidin-4-yl)methanol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- Z4573
- Product name
- (4-Methylpiperidin-4-yl)methanol
- Packaging
- 250mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- OR907789
- Product name
- (4-Methylpiperidin-4-yl)methanol
- Purity
- 95%
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- Z4573
- Product name
- (4-Methylpiperidin-4-yl)methanol
- Packaging
- 1g
- Price
- $189
- Updated
- 2021/12/16
- Product number
- OR907789
- Product name
- (4-Methylpiperidin-4-yl)methanol
- Purity
- 95%
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
4-Hydroxymethyl-4-methylpiperidine Chemical Properties,Usage,Production
Synthesis
878167-03-4
297172-16-8
Step 3: Synthesis of 4-(hydroxymethyl)-4-methylpiperidine To a solution of (1-benzyl-4-methylpiperidin-4-yl) methanol (2.7 g, 12 mmol) in methanol (34 mL) was sequentially added ammonium formate (8.6 g) and 10% palladium carbon catalyst (3.6 g, 1.7 mmol). The reaction mixture was stirred for 18 hours under a hydrogen balloon atmosphere. Upon completion of the reaction, the mixture was degassed, flushed with nitrogen and filtered through a diatomaceous earth pad to remove the catalyst. Subsequently, the solvent was evaporated under reduced pressure and the resulting crude product was purified by fast chromatography (silica gel, 40 g, ISCO system, eluent: 0-20% methanol gradient in dichloromethane) to afford 4-(hydroxymethyl)-4-methylpiperidine as a colorless oil, which was used directly in the next step of the reaction. After further purification, 1.2 g of the target product was obtained in 76% yield.
References
[1] Patent: WO2011/73263, 2011, A1. Location in patent: Page/Page column 147
[2] Patent: WO2006/23852, 2006, A2. Location in patent: Page/Page column 82-84
[3] Patent: WO2006/58303, 2006, A2. Location in patent: Page/Page column 69
[4] Patent: US2008/15179, 2008, A1. Location in patent: Page/Page column 120
[5] Patent: WO2007/100670, 2007, A1. Location in patent: Page/Page column 45-46
4-Hydroxymethyl-4-methylpiperidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Hydroxymethyl-4-methylpiperidine manufacturers
- Product
- 4-Hydroxymethyl-4-methylpiperidine 297172-16-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-08