ChemicalBook > CAS DataBase List > Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester

Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester

Product Name
Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester
CAS No.
159749-28-7
Chemical Name
Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester
Synonyms
1-Boc-azetidine-2-carboxylic acid;Boc-DL-Aze-OH;BOC-AZETIDINE-2-CARBOXYLIC ACID;N-Boc-Azetidine-2-carboxylic acid;1-Boc-L-azetidine-2-carboxylic acid;N-Boc-RS-2-Azetidinecarboxylic acid;1-N-BOC-AZETIDINE-2-CARBOXYLIC ACID;Azetidine-1,2-Carboxylic acid 1-tert-butyl ester;AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER;Azetidine-1,2-dicarboxylic acid ID 1-tert-butyl este
CBNumber
CB3215522
Molecular Formula
C9H15NO4
Formula Weight
201.22
MOL File
159749-28-7.mol
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Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester Property

Boiling point:
321.0±35.0 °C(Predicted)
Density 
1.246±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
4.01±0.20(Predicted)
form 
solid
color 
Pale yellow
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Safety

Hazard Codes 
Xi,N
Risk Statements 
36/37/38-50
Safety Statements 
26-36-61-24/25
RIDADR 
UN3077
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B700535
Product name
1-(tert-Butoxycarbonyl)azetidine-2-carboxylicAcid
Packaging
10mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA56478
Product name
Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester
Packaging
500mg
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-QQ
Product name
1-[(tert-Butoxy)carbonyl]azetidine-2-carboxylic acid
Purity
97.0%
Packaging
250mg
Price
$115
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA56478
Product name
Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester
Packaging
1g
Price
$120
Updated
2021/12/16
Apolloscientific
Product number
OR309044
Product name
Azetidine-1,2-dicarboxylicacid1-tert-butylester
Packaging
1g
Price
$128
Updated
2021/12/16
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Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester Chemical Properties,Usage,Production

Description

Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester (ADCBT) is a pyrrolidinyl nicotinic acetylcholine receptor agonist. ADCBT has been shown to have affinity values for neuronal nicotinic acetylcholine receptors that are significantly higher than those of nicotine. It has been shown to be regioselective in the sense that it binds preferentially to the alpha4beta2 subtype of the nicotinic acetylcholine receptor, which is present in both peripheral and central neurons. It also has a high affinity for the acetylcholine binding site at the neuromuscular junction. ADCBT has been shown to have analgesic effects in animal studies.

Chemical Properties

White powder

Uses

Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester, is an useful intermediate in the synthesis of pharmaceutical compounds including inhibitors and receptor Antagonists. It can be used in the synthesis of polypeptides.

Preparation

Sodium hydroxide (2.08 g, 51.92 mmol) was added to a solution of azetidine-2-carboxylic acid (5.00 g, 49.50 mmol), di-tert-butyl dicarbonate (13.50 g, 61.80 mmol) in ethanol (120.0 mL) at 0 °C. After stirring the reaction mixture for 8 hours, the pH of the mixture was adjusted to 2 with 1.0 N HCl and extracted with ethyl acetate (2 × 200 mL). The combined organic layers were washed with brine, separated, and dried over anhydrous sodium sulfate. Then the compound was concentrated under reduced pressure to afford Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester.

Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester manufacturers

Career Henan Chemical Co
Product
AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 159749-28-7
Price
US $6.86/KG
Min. Order
1KG
Purity
95.0%-99.0%
Supply Ability
1kg-100kg
Release date
2020-03-10

159749-28-7, Azetidine-1,2-dicarboxylic acid 1-tert-butyl esterRelated Search:

Boc-D-Azetidine-2-carboxylic acid (S)-Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester Azetidine Methyl 1-Boc-azetidine-3-carboxylate AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER AZETIDINE-1,3-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 3-ETHYL ESTER (S)-AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER AZETIDINE-1,3-DICARBOXYLIC ACID MONO-TERT-BUTYL ESTER (S)-N-BOC-AZETIDINE-2-CARBOXYLIC ACID METHYL ESTER AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-ETHYL ESTER 1-Boc-azetidine-2-carboxylic acid methyl ester Azetidine-1,2-dicarboxylic acid 1-tert-butyl ester

  • AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER
  • BOC-AZETIDINE-2-CARBOXYLIC ACID
  • 1-N-BOC-AZETIDINE-2-CARBOXYLIC ACID
  • N-Boc-Azetidine-2-carboxylic acid
  • 1-Boc-L-azetidine-2-carboxylic acid
  • 1-Boc-azetidine-2-carboxylic acid
  • N-Boc-RS-2-Azetidinecarboxylic acid
  • AZETIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER N-BOC-
  • 1-[(2-Methylpropan-2-yl)oxycarbonyl]azetidine-2-carboxylic Acid
  • Azetidine-1,2-Carboxylic acid 1-tert-butyl ester
  • 1,2-Azetidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester
  • Azetidine-1,2-dicarboxylic acid ID 1-tert-butyl ester
  • Boc-DL-Aze-OH
  • Azetidine-1,2-dicarboxylic acid ID 1-tert-butyl este
  • 159749-28-7
  • pharmacetical