Pyranoridine phosphate

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Pyranoridine phosphate

Product Name: Pyranoridine phosphate
CAS No.: 76748-86-2
Chemical Name: Pyranoridine phosphate
Synonyms: phosphate(1:4);pyranoridinephosphate;PYRANORIDINE TETRAPHOSPHATE;Pyranaridine tetraphosphate;76748-86-2 Pyranoridine phosphate;Pyranoridine phosphate ISO 9001：2015 REACH;4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pheno;4-((7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino)-2,6-bis(pyrrolidin-1-ylmethyl)phenol tetrakis(phosphate);2-Methoxy-7-chloro-10[3′,5′-bis(pyrrolidinyl-1-methyl-)4′-hydroxyphenyl]aminobenzyl-(b)-1,5-naphthyridine tetraphosphate;4-[(7-Chloro-2-methoxy-1,5-dihydropyrido[3,2-b]quinolin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one phosphate (1:4)
CBNumber: CB3222539
Molecular Formula: C29H35ClN5O6P
Formula Weight: 616.05
MOL File: 76748-86-2.mol

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Pyranoridine phosphate Property

Melting point:: 233-236° (dec)
storage temp.: 2-8°C
solubility: acetic acid: soluble5mg/mL
form: solid
color: Light yellow to yellow
InChIKey: YKUQEKXHQFYULM-UHFFFAOYSA-N

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Safety

Hazard Codes: Xn
Risk Statements: 63-22-41
Safety Statements: 26-36/37-39
WGK Germany: 2
RTECS: SK4920000
Toxicity: LD50 in mice (mg/kg): 251 ±33 i.m.; 1368 ±239 orally (Shao)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P0049
Product name: Pyronaridine tetraphosphate
Packaging: 250MG
Price: $265
Updated: 2023/06/20

Cayman Chemical

Product number: 16139
Product name: Pyronaridine (phosphate)
Purity: ≥98%
Packaging: 50mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 16139
Product name: Pyronaridine (phosphate)
Purity: ≥98%
Packaging: 100mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 16139
Product name: Pyronaridine (phosphate)
Purity: ≥98%
Packaging: 250mg
Price: $201
Updated: 2024/03/01

TRC

Product number: P997640
Product name: Pyronaridine tetraphosphate
Packaging: 50mg
Price: $325
Updated: 2021/12/16

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Pyranoridine phosphate Chemical Properties,Usage,Production

Uses

Pyronaridine Phosphate is an antimalarial drug.

Biological Activity

pyronaridine (pnd), a synthetic quinolone derivative frequently prescribed for the treatment of malaria, is a selective and potent multidrug resistance (mdr) modulator of pgp-mediated mdr that inhibits the proliferation of a variety of tumor cells, including myeloid leukemia (k562 and k562/a02), epidermoid carcinoma (kb and kbv200), breast carcinoma (mcf-7 and mcf-7/adr), ovarian carcinoma (skov3, es-2 and pa-1), gastric carcinoma (bgc-823), colon carcinoma (lovo), hepatocellular carcinoma (smmz-7721 and qgy-7703), with the half maximal inhibition concentration ic50 values of 8.3 μm, 5.6 μm, 20.8 μm, 14.5 μm, 9.5 μm, 11 μm, 9.7 μm, 12.9 μm, 15.7 μm, 14.9 μm, 21.4 μm, 10.9 μm and 17.1 μm respectively [1].

References

[1] qi j, wang s, liu g, peng h, wang j, zhu z, yang c. pyronaridine, a novel modulator of p-glycoprotein-mediated multidrug resistance in tumor cells in vitro and in vivo. biochem biophys res commun. 2004 jul 9;319(4):1124-31.

Pyranoridine phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Pyranoridine phosphate manufacturers

Dideu Industries Group Limited

Product: Pyranoridine phosphate 76748-86-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-21

76748-86-2, Pyranoridine phosphateRelated Search:

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PYRANORIDINE TETRAPHOSPHATE

4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pheno

phosphate(1:4)

pyranoridinephosphate

Pyranaridine tetraphosphate

4-[(7-Chloro-2-methoxy-1,5-dihydropyrido[3,2-b]quinolin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one phosphate (1:4)

2-Methoxy-7-chloro-10[3′,5′-bis(pyrrolidinyl-1-methyl-)4′-hydroxyphenyl]aminobenzyl-(b)-1,5-naphthyridine tetraphosphate

4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one,phosphoricaci

Pyranoridine phosphate ISO 9001：2015 REACH

4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one,phosphoric acid

76748-86-2 Pyranoridine phosphate

4-((7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino)-2,6-bis(pyrrolidin-1-ylmethyl)phenol tetrakis(phosphate)

76748-86-2

C29H32ClN5O24H3PO4

C29H32ClN5O24H3O4P

Inhibitor