ChemicalBook > CAS DataBase List > Pyranoridine phosphate

Pyranoridine phosphate

Product Name: Pyranoridine phosphate
CAS No.: 76748-86-2
Chemical Name: Pyranoridine phosphate
Synonyms: phosphate(1:4);Pyronaridine tetraph;pyranoridinephosphate;Tetraphenylene phosphate;PYRANORIDINE TETRAPHOSPHATE;Pyranaridine tetraphosphate;76748-86-2 Pyranoridine phosphate;Pyranoridine phosphate ISO 9001：2015 REACH;Pyronaridine tetraphosphate, 10 mM in DMSO;4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pheno
CBNumber: CB3222539
Molecular Formula: C29H35ClN5O6P
Formula Weight: 616.05
MOL File: 76748-86-2.mol

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Pyranoridine phosphate Property

Melting point:: 233-236° (dec)
storage temp.: 2-8°C
solubility: acetic acid: soluble5mg/mL
form: solid
color: Light yellow to yellow
InChIKey: YKUQEKXHQFYULM-UHFFFAOYSA-N

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Safety

Hazard Codes: Xn
Risk Statements: 63-22-41
Safety Statements: 26-36/37-39
WGK Germany: 2
RTECS: SK4920000
Toxicity: LD50 in mice (mg/kg): 251 ±33 i.m.; 1368 ±239 orally (Shao)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P0049
Product name: Pyronaridine tetraphosphate
Packaging: 250MG
Price: $265
Updated: 2023/06/20

Cayman Chemical

Product number: 16139
Product name: Pyronaridine (phosphate)
Purity: ≥98%
Packaging: 50mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 16139
Product name: Pyronaridine (phosphate)
Purity: ≥98%
Packaging: 100mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 16139
Product name: Pyronaridine (phosphate)
Purity: ≥98%
Packaging: 250mg
Price: $201
Updated: 2024/03/01

TRC

Product number: P997640
Product name: Pyronaridine tetraphosphate
Packaging: 50mg
Price: $325
Updated: 2021/12/16

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Pyranoridine phosphate Chemical Properties,Usage,Production

Uses

Pyronaridine Phosphate is an antimalarial drug.

Biological Activity

pyronaridine (pnd), a synthetic quinolone derivative frequently prescribed for the treatment of malaria, is a selective and potent multidrug resistance (mdr) modulator of pgp-mediated mdr that inhibits the proliferation of a variety of tumor cells, including myeloid leukemia (k562 and k562/a02), epidermoid carcinoma (kb and kbv200), breast carcinoma (mcf-7 and mcf-7/adr), ovarian carcinoma (skov3, es-2 and pa-1), gastric carcinoma (bgc-823), colon carcinoma (lovo), hepatocellular carcinoma (smmz-7721 and qgy-7703), with the half maximal inhibition concentration ic50 values of 8.3 μm, 5.6 μm, 20.8 μm, 14.5 μm, 9.5 μm, 11 μm, 9.7 μm, 12.9 μm, 15.7 μm, 14.9 μm, 21.4 μm, 10.9 μm and 17.1 μm respectively [1].

in vivo

Pyronaridine (57 mg/kg, oral administration, q.d. for 30 days) tetraphosphate reduces the parasitic burden in the Echinococcus granulosus-infected mice^[2].
Pyronaridine (57 mg/kg, intraperitoneal injection, q.d. for 3 days) tetraphosphate reduces the parasitic burden in secondarily infected (cysts) mice^[2].
Pyronaridine (57 mg/kg, intraperitoneal injection, for a single dose) tetraphosphate exhibits a higher exposure in the liver than in the plasma in male ICR mice^[2].

Animal Model:	Echinococcus granulosus-infected mice model^[2]
Dosage:	57 mg/kg
Administration:	Oral administration, q.d. for 30 days
Result:	Reduced 42.4% of parasite wet weight and killed 90.7% of secondary infection (cysts) of E. granulosus ss.

IC 50

Plasmodium

References

[1] qi j, wang s, liu g, peng h, wang j, zhu z, yang c. pyronaridine, a novel modulator of p-glycoprotein-mediated multidrug resistance in tumor cells in vitro and in vivo. biochem biophys res commun. 2004 jul 9;319(4):1124-31.

Pyranoridine phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Pyranoridine phosphate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Pyranoridine phosphate 76748-86-2
Price: US $1.00-4.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000KG
Release date: 2025-05-14

Dideu Industries Group Limited

Product: Pyranoridine phosphate 76748-86-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-21

76748-86-2, Pyranoridine phosphateRelated Search:

N-Vinyl-2-pyrrolidone Pyrroloquinoline quinone 2-Methoxyethanol Creatine phosphate Trisodium phosphate Povidone iodine Zinc phosphate Ammonium dihydrogen phosphate Calcium phosphate N-Methyl-2-pyrrolidone Polyvinylpyrrolidone Sodium Phosphate Monobasic Monohydrate Pyrrolidine FERRIC PHOSPHATE phosphate METHYL-2-PYRROLIDONE Pyronaridine Amopyroquine

PYRANORIDINE TETRAPHOSPHATE

4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pheno

phosphate(1:4)

pyranoridinephosphate

Pyranaridine tetraphosphate

4-[(7-Chloro-2-methoxy-1,5-dihydropyrido[3,2-b]quinolin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one phosphate (1:4)

2-Methoxy-7-chloro-10[3′,5′-bis(pyrrolidinyl-1-methyl-)4′-hydroxyphenyl]aminobenzyl-(b)-1,5-naphthyridine tetraphosphate

4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one,phosphoricaci

Pyranoridine phosphate ISO 9001：2015 REACH

4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one,phosphoric acid

76748-86-2 Pyranoridine phosphate

4-((7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino)-2,6-bis(pyrrolidin-1-ylmethyl)phenol tetrakis(phosphate)

Pyronaridine tetraphosphate, 10 mM in DMSO

Pyronaridine tetraph

4- [(7-Chloro-2-Methoxy-1,5-dihydropyridineo [3,2-b] quinolin-10-yl) imine] -2,6-di (pyrrolidin-1-ylmethyl) cyclohexene-2,5-dien-1-one phosphate (1:4)

Tetraphenylene phosphate

76748-86-2

C29H32ClN5O24H3PO4

C29H32ClN5O24H3O4P

Inhibitor