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Pyranoridine phosphate

Product Name
Pyranoridine phosphate
CAS No.
76748-86-2
Chemical Name
Pyranoridine phosphate
Synonyms
phosphate(1:4);Pyronaridine tetraph;pyranoridinephosphate;Tetraphenylene phosphate;PYRANORIDINE TETRAPHOSPHATE;Pyranaridine tetraphosphate;76748-86-2 Pyranoridine phosphate;Pyranoridine phosphate ISO 9001：2015 REACH;Pyronaridine tetraphosphate, 10 mM in DMSO;4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pheno
CBNumber
CB3222539
Molecular Formula
C29H35ClN5O6P
Formula Weight
616.05
MOL File
76748-86-2.mol
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Pyranoridine phosphate Property

Melting point:
233-236° (dec)
storage temp. 
2-8°C
solubility 
acetic acid: soluble5mg/mL
form 
solid
color 
Light yellow to yellow
InChIKey
YKUQEKXHQFYULM-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xn
Risk Statements 
63-22-41
Safety Statements 
26-36/37-39
WGK Germany 
2
RTECS 
SK4920000
Toxicity
LD50 in mice (mg/kg): 251 ±33 i.m.; 1368 ±239 orally (Shao)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P0049
Product name
Pyronaridine tetraphosphate
Packaging
250MG
Price
$265
Updated
2023/06/20
Cayman Chemical
Product number
16139
Product name
Pyronaridine (phosphate)
Purity
≥98%
Packaging
50mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
16139
Product name
Pyronaridine (phosphate)
Purity
≥98%
Packaging
100mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
16139
Product name
Pyronaridine (phosphate)
Purity
≥98%
Packaging
250mg
Price
$201
Updated
2024/03/01
TRC
Product number
P997640
Product name
Pyronaridine tetraphosphate
Packaging
50mg
Price
$325
Updated
2021/12/16
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Pyranoridine phosphate Chemical Properties,Usage,Production

Uses

Pyronaridine Phosphate is an antimalarial drug.

Biological Activity

pyronaridine (pnd), a synthetic quinolone derivative frequently prescribed for the treatment of malaria, is a selective and potent multidrug resistance (mdr) modulator of pgp-mediated mdr that inhibits the proliferation of a variety of tumor cells, including myeloid leukemia (k562 and k562/a02), epidermoid carcinoma (kb and kbv200), breast carcinoma (mcf-7 and mcf-7/adr), ovarian carcinoma (skov3, es-2 and pa-1), gastric carcinoma (bgc-823), colon carcinoma (lovo), hepatocellular carcinoma (smmz-7721 and qgy-7703), with the half maximal inhibition concentration ic50 values of 8.3 μm, 5.6 μm, 20.8 μm, 14.5 μm, 9.5 μm, 11 μm, 9.7 μm, 12.9 μm, 15.7 μm, 14.9 μm, 21.4 μm, 10.9 μm and 17.1 μm respectively [1].

in vivo

Pyronaridine (57 mg/kg, oral administration, q.d. for 30 days) tetraphosphate reduces the parasitic burden in the Echinococcus granulosus-infected mice[2].
Pyronaridine (57 mg/kg, intraperitoneal injection, q.d. for 3 days) tetraphosphate reduces the parasitic burden in secondarily infected (cysts) mice[2].
Pyronaridine (57 mg/kg, intraperitoneal injection, for a single dose) tetraphosphate exhibits a higher exposure in the liver than in the plasma in male ICR mice[2].

Animal Model:Echinococcus granulosus-infected mice model[2]
Dosage:57 mg/kg
Administration:Oral administration, q.d. for 30 days
Result:Reduced 42.4% of parasite wet weight and killed 90.7% of secondary infection (cysts) of E. granulosus ss.

IC 50

Plasmodium

References

[1] qi j, wang s, liu g, peng h, wang j, zhu z, yang c. pyronaridine, a novel modulator of p-glycoprotein-mediated multidrug resistance in tumor cells in vitro and in vivo. biochem biophys res commun. 2004 jul 9;319(4):1124-31.

Pyranoridine phosphate Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyranoridine phosphate Suppliers

Canada 1 China 65 France 1 Germany 1 India 4 United States 11 Global 83
Alsachim SAS
Tel
--
Fax
--
Email
sales@alsachim.com
Country
France
ProdList
424
Advantage
0
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View Lastest Price from Pyranoridine phosphate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Pyranoridine phosphate 76748-86-2
Price
US $1.00-4.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2025-05-14
Dideu Industries Group Limited
Product
Pyranoridine phosphate 76748-86-2
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-21

76748-86-2, Pyranoridine phosphateRelated Search:

N-Vinyl-2-pyrrolidone Pyrroloquinoline quinone 2-Methoxyethanol Creatine phosphate Trisodium phosphate Povidone iodine Zinc phosphate Ammonium dihydrogen phosphate Calcium phosphate N-Methyl-2-pyrrolidone Polyvinylpyrrolidone Sodium Phosphate Monobasic Monohydrate Pyrrolidine FERRIC PHOSPHATE phosphate METHYL-2-PYRROLIDONE Pyronaridine Amopyroquine

  • PYRANORIDINE TETRAPHOSPHATE
  • 4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pheno
  • phosphate(1:4)
  • pyranoridinephosphate
  • Pyranaridine tetraphosphate
  • 4-[(7-Chloro-2-methoxy-1,5-dihydropyrido[3,2-b]quinolin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one phosphate (1:4)
  • 2-Methoxy-7-chloro-10[3′,5′-bis(pyrrolidinyl-1-methyl-)4′-hydroxyphenyl]aminobenzyl-(b)-1,5-naphthyridine tetraphosphate
  • 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one,phosphoricaci
  • Pyranoridine phosphate ISO 9001：2015 REACH
  • 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one,phosphoric acid
  • 76748-86-2 Pyranoridine phosphate
  • 4-((7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino)-2,6-bis(pyrrolidin-1-ylmethyl)phenol tetrakis(phosphate)
  • Pyronaridine tetraphosphate, 10 mM in DMSO
  • Pyronaridine tetraph
  • 4- [(7-Chloro-2-Methoxy-1,5-dihydropyridineo [3,2-b] quinolin-10-yl) imine] -2,6-di (pyrrolidin-1-ylmethyl) cyclohexene-2,5-dien-1-one phosphate (1:4)
  • Tetraphenylene phosphate
  • 76748-86-2
  • C29H32ClN5O24H3PO4
  • C29H32ClN5O24H3O4P
  • Inhibitor