Pyranoridine phosphate
- Product Name
- Pyranoridine phosphate
- CAS No.
- 76748-86-2
- Chemical Name
- Pyranoridine phosphate
- Synonyms
- phosphate(1:4);pyranoridinephosphate;PYRANORIDINE TETRAPHOSPHATE;Pyranaridine tetraphosphate;76748-86-2 Pyranoridine phosphate;Pyranoridine phosphate ISO 9001：2015 REACH;4-((7-chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pheno;4-((7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino)-2,6-bis(pyrrolidin-1-ylmethyl)phenol tetrakis(phosphate);2-Methoxy-7-chloro-10[3′,5′-bis(pyrrolidinyl-1-methyl-)4′-hydroxyphenyl]aminobenzyl-(b)-1,5-naphthyridine tetraphosphate;4-[(7-Chloro-2-methoxy-1,5-dihydropyrido[3,2-b]quinolin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one phosphate (1:4)
- CBNumber
- CB3222539
- Molecular Formula
- C29H35ClN5O6P
- Formula Weight
- 616.05
- MOL File
- 76748-86-2.mol
Pyranoridine phosphate Property
- Melting point:
- 233-236° (dec)
- storage temp.
- 2-8°C
- solubility
- acetic acid: soluble5mg/mL
- form
- solid
- color
- Light yellow to yellow
- InChIKey
- YKUQEKXHQFYULM-UHFFFAOYSA-N
Safety
- Hazard Codes
- Xn
- Risk Statements
- 63-22-41
- Safety Statements
- 26-36/37-39
- WGK Germany
- 2
- RTECS
- SK4920000
- Toxicity
- LD50 in mice (mg/kg): 251 ±33 i.m.; 1368 ±239 orally (Shao)
N-Bromosuccinimide Price
- Product number
- P0049
- Product name
- Pyronaridine tetraphosphate
- Packaging
- 250MG
- Price
- $265
- Updated
- 2023/06/20
- Product number
- 16139
- Product name
- Pyronaridine (phosphate)
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 16139
- Product name
- Pyronaridine (phosphate)
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 16139
- Product name
- Pyronaridine (phosphate)
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $201
- Updated
- 2024/03/01
- Product number
- P997640
- Product name
- Pyronaridine tetraphosphate
- Packaging
- 50mg
- Price
- $325
- Updated
- 2021/12/16
Pyranoridine phosphate Chemical Properties,Usage,Production
Uses
Pyronaridine Phosphate is an antimalarial drug.
Biological Activity
pyronaridine (pnd), a synthetic quinolone derivative frequently prescribed for the treatment of malaria, is a selective and potent multidrug resistance (mdr) modulator of pgp-mediated mdr that inhibits the proliferation of a variety of tumor cells, including myeloid leukemia (k562 and k562/a02), epidermoid carcinoma (kb and kbv200), breast carcinoma (mcf-7 and mcf-7/adr), ovarian carcinoma (skov3, es-2 and pa-1), gastric carcinoma (bgc-823), colon carcinoma (lovo), hepatocellular carcinoma (smmz-7721 and qgy-7703), with the half maximal inhibition concentration ic50 values of 8.3 μm, 5.6 μm, 20.8 μm, 14.5 μm, 9.5 μm, 11 μm, 9.7 μm, 12.9 μm, 15.7 μm, 14.9 μm, 21.4 μm, 10.9 μm and 17.1 μm respectively [1].
References
[1] qi j, wang s, liu g, peng h, wang j, zhu z, yang c. pyronaridine, a novel modulator of p-glycoprotein-mediated multidrug resistance in tumor cells in vitro and in vivo. biochem biophys res commun. 2004 jul 9;319(4):1124-31.
Pyranoridine phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
Pyranoridine phosphate Suppliers
- Tel
- --
- Fax
- --
- sales@chemos-group.com
- Country
- Germany
- ProdList
- 6350
- Advantage
- 71
View Lastest Price from Pyranoridine phosphate manufacturers
- Product
- Pyranoridine phosphate 76748-86-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-21