ChemicalBook > CAS DataBase List > Citric acid monohydrate

Citric acid monohydrate

Product Name
Citric acid monohydrate
CAS No.
5949-29-1
Chemical Name
Citric acid monohydrate
Synonyms
citric;ACETONUM;ACETONE D;PROPANONE;FEMA 3326;Ctric Acid;ACETONE 300;ACETONE 5000;EXTRAN AP 22;METHYL KETONE
CBNumber
CB3235573
Molecular Formula
C6H10O8
Formula Weight
210.1388
MOL File
5949-29-1.mol
More
Less

Citric acid monohydrate Property

Melting point:
-94 °C(lit.)
Boiling point:
56 °C760 mm Hg(lit.)
Density 
0.791 g/mL at 25 °C(lit.)
vapor density 
2 (vs air)
vapor pressure 
184 mm Hg ( 20 °C)
refractive index 
n20/D 1.359(lit.)
Flash point:
1 °F
storage temp. 
no restrictions.
solubility 
Citric Acid Monohydrate is very soluble in water, freely soluble in ethanol and sparingly soluble in ether.
pka
3.138, 4.76, 6.401
form 
Solid
color 
White
Specific Gravity
0.810 (20/4℃)
PH
1.85 (50g/l, H2O, 25℃)
Water Solubility 
1630 g/L (20 oC) ;H2O: soluble 54% (w/w) at 10°C (Citric acid in water)
Sensitive 
Hygroscopic
Merck 
14,2326
BRN 
4018641
Stability:
Stable. Incompatible with oxidizing agents, bases, reducing agents, nitrates.
InChIKey
YASYEJJMZJALEJ-UHFFFAOYSA-N
CAS DataBase Reference
5949-29-1(CAS DataBase Reference)
NIST Chemistry Reference
Citric acid monohydrate(5949-29-1)
EPA Substance Registry System
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, hydrate (1:1) (5949-29-1)
More
Less

Safety

Hazard Codes 
F,Xi
Risk Statements 
11-36-66-67-41-36/37/38-37/38
Safety Statements 
9-16-26-37/39-36/37/39-36
RIDADR 
UN 1090 3/PG 2
WGK Germany 
1
RTECS 
AL3150000
TSCA 
Yes
HS Code 
29181400
Toxicity
LD50 orally in Rabbit: 3000 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1.37003
Product name
Citric acid monohydrate
Purity
cryst. EMPROVE? EXPERT Ph Eur,BP,JP,USP,ACS
Packaging
1 kg
Price
$71.1
Updated
2021/03/22
Sigma-Aldrich
Product number
1.00244
Product name
Citric acid monohydrate
Purity
for analysis EMSURE? ACS,ISO,Reag. Ph Eur
Packaging
500 g
Price
$75.2
Updated
2021/03/22
Sigma-Aldrich
Product number
1.00244
Product name
Citric acid monohydrate
Purity
for analysis EMSURE? ACS,ISO,Reag. Ph Eur
Packaging
1 kg
Price
$98.97
Updated
2021/03/22
Sigma-Aldrich
Product number
1.00242
Product name
Citric acid monohydrate
Purity
cryst. EMPROVE? ESSENTIAL Ph Eur,BP,JP,USP,E 330,FCC
Packaging
5 kg
Price
$125
Updated
2021/03/22
Sigma-Aldrich
Product number
C0706
Product name
Citric acid monohydrate
Purity
BioXtra, ≥99.5%
Packaging
500g
Price
$105
Updated
2021/03/22
More
Less

Citric acid monohydrate Chemical Properties,Usage,Production

Chemical Properties

Citric acid monohydrate occurs as colorless or translucent crystals, or as a white crystalline, efflorescent powder. It is odorless and has a strong acidic taste. The crystal structure is orthorhombic. monohydrate crystals lose water of crystallization in dry air or when heated to about 40 to 50 °C. Citric acid monohydrate softens at 75 °C and melts at approximately 100 °C.

Citric acid monohydrate is a natural preservative and is used to add an acidic, or sour, taste to foods and soft drinks.
Citric acid monohydrate acts as a preservative and antioxidant. It is also used as an acidulant, flavoring agent and antistaling agent in fruit drinks, candy, cookies, biscuits, canned fruits, jams, and jellies. It differs from other forms of citric acid by having a moisture percentage ranging from 7.5-9.0.

Uses

Citric Acid Monohydrate is used as an Acidulate, Food additive, Pharmaceutical application and as a synergist in antioxidant mixtures.
Citric Acid Monohydrate is a tricarboxylic acid found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties. It maintains stability of active ingredients and is used as a preservative. It is also used as an acidulant to control pH and acts as an anticoagulant by chelating calcium in blood.

Production Methods

Citric acid occurs naturally in a number of plant species and may be extracted from lemon juice, which contains 5–8% citric acid, or pineapple waste. Anhydrous citric acid may also be produced industrially by mycological fermentation of crude sugar solutions such as molasses, using strains of Aspergillus niger . Citric acid is purified by recrystallization; the anhydrous form is obtained from a hot concentrated aqueous solution and the monohydrate from a cold concentrated aqueous solution.

Pharmaceutical Applications

Citric acid (as either the monohydrate or anhydrous material) is widely used in pharmaceutical formulations and food products, primarily to adjust the pH of solutions. It has also been used experimentally to adjust the pH of tablet matrices in enteric-coated formulations for colon-specific drug delivery. Citric acid monohydrate is used in the preparation of effervescent granules, while anhydrous citric acid is widely used in the preparation of effervescent tablets. Citric acid has also been shown to improve the stability of spray-dried insulin powder in inhalation formulations.
In food products, citric acid is used as a flavor enhancer for its tart, acidic taste. Citric acid monohydrate is used as a sequestering agent and antioxidant synergist. It is also a component of anticoagulant citrate solutions. Therapeutically, preparations containing citric acid have been used to dissolve renal calculi.

Biotechnological Applications

Citric acid monohydrate was used in the preparation of citric acid solution employed in the acetone method of 68Ga pre-purification and radiolabeling technique.
It may be used:
As release-modifying agent to improve the release of diltiazem hydrochloride from melt extruded Eudragit RS PO tablets.
To prepare citrate buffer for use in the preparation of platelets for intravital microscopy.
To prepare Tris-citrate buffer employed for the electrophoresis of bacterial enzymes.

Safety

Citric acid is found naturally in the body, mainly in the bones, and is commonly consumed as part of a normal diet. Orally ingested citric acid is absorbed and is generally regarded as a nontoxic material when used as an excipient. However, excessive or frequent consumption of citric acid has been associated with erosion of the teeth.
Citric acid and citrates also enhance intestinal aluminum absorption in renal patients, which may lead to increased, harmful serum aluminum levels. It has therefore been suggested that patients with renal failure taking aluminum compounds to control phosphate absorption should not be prescribed citric acid or citrate-containing products.

storage

Citric acid monohydrate loses water of crystallization in dry air or when heated to about 408℃. It is slightly deliquescent in moist air. Dilute aqueous solutions of citric acid may ferment on standing.

Purification Methods

Crystallise it from hot H2O solution (w/w solubility is 54% at 10o, 71% at 50o and 84% at 100o. The monohydrate (softens at ~75o and melts at ~100o) dehydrates in air or when heated gently above 40o . The triethylester ( M 276.3, b 127o/1mm, 294o/atm, d 4 1.137, n D 1.4420.) is a bitter tasting oil. [Beilstein 3 H 556 and 568, 3 IV 1272.]

Incompatibilities

Citric acid is incompatible with potassium tartrate, alkali and alkaline earth carbonates and bicarbonates, acetates, and sulfides. Incompatibilities also include oxidizing agents, bases, reducing agents, and nitrates. It is potentially explosive in combination with metal nitrates. On storage, sucrose may crystallize from syrups in the presence of citric acid.

Regulatory Status

GRAS listed. The anhydrous form is accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations; IM, IV, and other injections; ophthalmic preparations; oral capsules, solutions, suspensions and tablets; topical and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in Japan and the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

More
Less

Citric acid monohydrate Suppliers

Shanghai junxin chemical co., ltd
Tel
Email
45027395@qq.com
Country
China
ProdList
20
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
021-20337333-801
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24980
Advantage
65
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
551-65418684- ;551-65418679-
Fax
0551-65418697
Email
info@tnjchem.com;sales@tnjchem.com
Country
China
ProdList
1895
Advantage
62
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
Beijing dtftchem Technology Co., Ltd.
Tel
13651141086; 86(10)60275028、60275820
Fax
86 (10) 60270825
Email
dtftchem@sina.com
Country
China
ProdList
3392
Advantage
62
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057-
Fax
0757-86311057
Email
sales.gd@hwrkchemical.com
Country
China
ProdList
17295
Advantage
55
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43495
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028-
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12356
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078;021-50426030
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
10006
Advantage
60
Adamas Reagent, Ltd.
Tel
400-600-9262
Email
bxy@titansci.com
Country
China
ProdList
13915
Advantage
59
Accela ChemBio Co.,Ltd.
Tel
400-0665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11499
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202- ; ;
Email
jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com
Country
China
ProdList
43255
Advantage
64
Chengdu XiYa Chemical Technology Co., Ltd.
Tel
;
Fax
0539-6365991
Email
sale@xiyashiji.com;3007716753@qq.com
Country
China
ProdList
10578
Advantage
57
Syntechem Co.,Ltd
Tel
Please Email
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
13009
Advantage
57
BEST-REAGENT
Tel
400-1166-196;028-84555506- ;028-84555506-
Email
cdhxsj@163.com;1955352637@qq.com;cdhxsj@163.com
Country
China
ProdList
11718
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006;021-38701807;021-58950017
Fax
0086-21-58956100
Country
China
ProdList
7833
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14457
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9844
Advantage
79
Jinhua City Mingzhu Pharmaccutical Co.,Ltd.
Tel
+86 579 82207761
Fax
+86 579 82207765
Email
sst33@163.com
Country
China
ProdList
18
Advantage
62
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 QQ:452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11737
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-67601398-809
Fax
021-57711696
Email
marketing_china@spectrumchemical.com;
Country
China
ProdList
9686
Advantage
60
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852-
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2957
Advantage
58
Dalian Meilun Biotech Co., Ltd.
Tel
0411-66864596- ;0411-66864952-
Email
sales@meilune.com;sales@meilune.com
Country
China
ProdList
3576
Advantage
58
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847-
Fax
021-55068248
Email
3008007399@qq.com
Country
China
ProdList
4995
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
028-85911938-
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9750
Advantage
55
Qingdao Free Trade Zone United International Co.,Ltd.
Tel
0532-83893697-
Fax
83893695
Email
sissili@unitedint.com
Country
China
ProdList
352
Advantage
58
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17441
Advantage
75
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725;010-86181995
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12341
Advantage
58
Beijing innoChem Science & Technology Co.,Ltd.
Tel
400-810-7969 010-59572699
Fax
010-59572688
Email
ningzi.li@inno-chem.com.cn
Country
China
ProdList
6149
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280-
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
21578
Advantage
55
Cheng Du Micxy Chemical Co.,Ltd
Tel
028-85632863-
Fax
028-85632863
Email
sales@micxy.com;
Country
China
ProdList
13065
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22541
Advantage
55
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9542
Advantage
55
VOT INTERNATIONAL BUSINESS CO.,LTD
Tel
0536-2456718
Fax
0536-8231856
Email
market@votchemical.com
Country
China
ProdList
226
Advantage
55
Shanghai TaoShu Biochemical Technology Co., Ltd.
Tel
021-33632979-
Fax
021-33632979
Email
service1@targetmol.com
Country
China
ProdList
7962
Advantage
58
Shanghai Huikai Chemical Technology Co., Ltd.
Tel
021-61995394 18916691159
Email
chemicalsea@163.com
Country
China
ProdList
1981
Advantage
58
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791/13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3930
Advantage
50
Beijing Universal Century Technology Co., Ltd.
Tel
400-8706899
Fax
400-8706899
Email
hysj_bj.com
Country
China
ProdList
3602
Advantage
55
Vientiane Tianjin Hengyuan Technology Co., Ltd.
Tel
15722085254
Fax
022-26358246
Email
phytochemical@126.com
Country
China
ProdList
813
Advantage
55
TianJin Alta Scientific Co., Ltd.
Tel
+86-022-6537-8550
Fax
+86-022-2532-9655
Email
contact@altascientific.com
Country
China
ProdList
2775
Advantage
58
Bide Pharmatech Ltd.
Tel
021-61629020-8031;
Fax
+86-21-61629029
Email
sales@bldpharm.com;product07@bidepharmatech.com
Country
China
ProdList
39458
Advantage
60
Shanghai Worldyang Chemical Co.,Ltd.
Tel
+86-21-56791066;56795766;56795797
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9355
Advantage
58
Dalian Rivin Technology Co., Ltd
Tel
86-0411-62789512
Fax
86-0411-62789510
Email
xj_cui@dlrivin.com
Country
China
ProdList
123
Advantage
56
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366-
Email
sales@chem-strong.com
Country
China
ProdList
26596
Advantage
56
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196;028-84555506- ;028-84555506-
Fax
QQ:800101999
Email
cdhxsj@163.com;cdhxsj@163.com;cdhxsj@163.com
Country
China
ProdList
13362
Advantage
58
Shanghai CanSpecsci Instrument Co., Ltd.
Tel
400-6087598
Fax
4006087598-8012
Email
order@canspecsci.com
Country
China
ProdList
3807
Advantage
56
Shanghai YuLue Chemical Co., Ltd.
Tel
021-13671753212 13917602471 021-60345187
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10081
Advantage
55
More
Less

View Lastest Price from Citric acid monohydrate manufacturers

Wuhan wingroup Pharmaceutical Co., Ltd
Product
Citric acid monohydrate 5949-29-1
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
30 Tons
Release date
2021-07-01
Baoji Guokang Healthchem co.,ltd
Product
Citric acid monohydrate 5949-29-1
Price
US $960.00/KG
Min. Order
25KG
Purity
99%
Supply Ability
200tons
Release date
2021-06-04
Wuhan Monad Medicine Tech Co.,LTD
Product
Citric acid monohydrate 5949-29-1
Price
US $10.00/Kg/Drum
Min. Order
1g/Bag
Purity
99%min
Supply Ability
5000
Release date
2021-04-16

5949-29-1, Citric acid monohydrateRelated Search:


  • 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, monohydrate
  • 1,2,3-Propanetricarboxylicacid,2-hydroxy-,monohydrate
  • 2,3-propanetricarboxylicacid,2-hydroxy-monohydrate
  • citric
  • Citric acid hydrate
  • Citricacidhydrate
  • Citronensαure-hydrat
  • Citric acid monohydrate, 99.5+%
  • Citric acid monohydrate
  • 3-Carboxy-3-hydroxy-pentanedioic acid monohydrate
  • 1,2,3-Tricarboxy-2-hydroxypropane,2-Hydroxy-1,2,3-propanetricarboxylic acid,β-Hydroxytricarballylic acid
  • CITRICACID,MONOHYDRATE,BIOTECHGRADE
  • CITRICACID,MONOHYDRATE,CRYSTAL,REAGENT,ACS
  • CITRICACID,MONOHYDRATE,GRANULAR,FCC
  • CITRICACID,MONOHYDRATE,GRANULAR,USP
  • CITRICACID,MONOHYDRATE,POWDER,USP
  • citric acid free acid monohydrate*crystalline
  • Citric Acid Monohydrate BP
  • Hydrous citric acid
  • CITRIC ACID MONOHYDRATE USP
  • CITRIC ACID MONOHYDRATE SIGMAULTRA
  • CITRIC ACID MONOHYDRATE ACS REAGENT
  • CITRIC ACID MONOHYDRATE, ACS
  • CITRIC ACID MONOHYDRATE PURISS. P.A.,REAG. ACS, REAG. ISO, REAG.
  • CITRIC ACID-1-HYDRATE GRITTY, EXTRA PURE
  • CITRIC ACID MONOHYDRATE, PH EUR
  • CITRIC ACID MONOHYDRATE, 99%, A.C.S. REA GENT
  • CitricAcidMonohydrateBp93/Bp98/E330/Usp24/Fcciv
  • CitricAcidC6H8O7*H2O
  • CitricAcidMonohydrateFcc
  • CitricAcidAnhydrousExtraPure
  • CitricAcidPure(Monohydrate)
  • CitricAcidMonohydrateAr
  • CitricAcidMonohydrateIp
  • Citricacid,monohydrate,ACS,99.0-102.0%
  • CITRIC ACID 1 H2O
  • Citric acid monohydrate, for analysis, 99.5%
  • CITRIC ACID, MONOHYDRATE REAGENT (ACS)
  • Citric acid monohydr
  • Citric Acid Monohydrate, Crystalline Powder, USP
  • Citric acid Monohydrate, for analysis, 99.5% 1KG
  • Citric acid Monohydrate, for analysis, 99.5% 250GR
  • Citric acid monohydrate, molecular biology grade
  • CITRIC ACID, ACS
  • CITRIC ACID, MONOHYDRATE LOW METALS GRADE
  • Citric acid Monohydrate, technical, pearls
  • 2-hydroxypropane-1,2,3-tricarboxylic acid hydrate
  • Citric acid Monohydrate (CAM)
  • Citric acid(awater
  • Citric acid Monohydrate reagent grade, >=98% (GC/titration)
  • Acetone, 99%, SpcDry, with Molecular sieves, Water≤50 ppM (by K.F.), SpcSeal
  • Citric acid Mo
  • CitronensαureMonohydrat
  • AKOS BBS-00004268
  • ACETONE: ALCOHOL DECOLORIZER SOLUTION
  • ACETONE, BUFFERED
  • ACETONE, BUFFERED, TS
  • ACETONE 300