ChemicalBook > CAS DataBase List > 2-Dimethylaminoisopropyl chloride hydrochloride

2-Dimethylaminoisopropyl chloride hydrochloride

Product Name
2-Dimethylaminoisopropyl chloride hydrochloride
CAS No.
4584-49-0
Chemical Name
2-Dimethylaminoisopropyl chloride hydrochloride
Synonyms
DMIC;2-DIMETHYLAMINO ISOPROPYL CHLORIDE HCL;1-(DIMETHYLAMINO)-2-CHLOROPROPANE HYDROCHLORIDE;B-DIMETHYLAMINOISOPROPYL CHLORIDE HYDROCHLORIDE;2-DMPC;2-DMPC 99%;DMIC 99%min;Lipoic acid 62-46-4;2-Dimethylaminoisopropyl;intermediate of Methadone
CBNumber
CB3235881
Molecular Formula
C5H13Cl2N
Formula Weight
158.07
MOL File
4584-49-0.mol
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2-Dimethylaminoisopropyl chloride hydrochloride Property

Melting point:
187-190 °C(lit.)
storage temp. 
Store below +30°C.
solubility 
2000g/l
form 
Crystalline Powder
color 
White to light cream
PH
5-6 (500g/l, H2O, 20℃)
Water Solubility 
2000 g/L (20 º C)
Sensitive 
Hygroscopic
BRN 
3670215
InChI
InChI=1S/C5H12ClN.ClH/c1-5(6)4-7(2)3;/h5H,4H2,1-3H3;1H
InChIKey
OCWGRWAYARCRTQ-UHFFFAOYSA-N
SMILES
C(Cl)(C)CN(C)C.Cl
CAS DataBase Reference
4584-49-0(CAS DataBase Reference)
EPA Substance Registry System
2-Chloro-N,N-dimethyl-1-propanamine hydrochloride (4584-49-0)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36
RIDADR 
2811
WGK Germany 
3
RTECS 
TY1225000
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29211980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D142409
Product name
2-Chloro-N,N-dimethylpropylamine hydrochloride
Purity
98%
Packaging
100g
Price
$33.3
Updated
2024/03/01
Sigma-Aldrich
Product number
8.03240
Product name
N-(2-Chloropropyl)-N,N-dimethylammonium chloride
Purity
for synthesis
Packaging
250G
Price
$95.6
Updated
2024/03/01
TCI Chemical
Product number
D1665
Product name
2-Chloro-1-(dimethylamino)propane Hydrochloride
Purity
>98.0%(T)
Packaging
25g
Price
$24
Updated
2024/03/01
TCI Chemical
Product number
D1665
Product name
2-Chloro-1-(dimethylamino)propane Hydrochloride
Purity
>98.0%(T)
Packaging
500g
Price
$279
Updated
2024/03/01
Alfa Aesar
Product number
B20882
Product name
2-Dimethylaminoisopropyl chloride hydrochloride, 98%
Packaging
500g
Price
$97.2
Updated
2023/06/20
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2-Dimethylaminoisopropyl chloride hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Colourless to pale beige crystalline powder

Uses

2-Chloro-N,N-dimethylpropylamine hydrochloride (DMIC) is used as intermediate for the syntheses of pharmaceuticals (e.g. isothipendyl, methadone and promethazine)

Uses

Hydrochloride salt of 2-Dimethylaminoisopropyl Chloride, used in the synthesis of analogues of lipophilic chalcones, which act as antitubercular agents.

General Description

Off-white chunky solid.

Air & Water Reactions

2-Dimethylaminoisopropyl chloride hydrochloride is hygroscopic. Soluble in water.

Reactivity Profile

2-Dimethylaminoisopropyl chloride hydrochloride is incompatible with strong oxidizing agents. . Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Fire Hazard

Flash point data for 2-Dimethylaminoisopropyl chloride hydrochloride are not available; however, 2-Dimethylaminoisopropyl chloride hydrochloride is probably combustible.

Synthesis


Following the procedure of Schultz and Sprague, J. Am. Chem. Soc., 70, 48 (1948), a solution containing 3.77 g. of 1-dimethylamino-2-propanol and 10 ml. of chloroform was cooled with stirring to a temperature of about 0?? C. A solution of 5.72 g. of freshly distilled thionylchloride in 2 ml. of chloroform was added thereto. The reaction mixture was allowed to come to ambient temperature over a period of about 30 minutes and was then heated to refluxing temperature for an additional 30 minutes. The precipitated material redissolved on heating. 1-Dimethylamino-2-chloropropane hydrochloride began to crystallize from the boiling solvent. The reaction mixture was cooled, diluted with ether and filtered. The reaction product comprising 1-dimethylamino-2-chloropropane hydrochloride weighed about 5.5 g. (95 percent yield). Recrystallization yielded purified 1-dimethylamino-2-chloropropane hydrochloride melting at 192??-194?? C.

2-Dimethylaminoisopropyl chloride hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Dimethylaminoisopropyl chloride hydrochloride Suppliers

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View Lastest Price from 2-Dimethylaminoisopropyl chloride hydrochloride manufacturers

Dorne Chemical Technology co. LTD
Product
2-DMPC 4584-49-0
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2024-05-25
Jinan Finer Chemical Co., Ltd
Product
2-Dimethylaminoisopropyl chloride hydrochloride 4584-49-0
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
100mt
Release date
2020-11-05
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
2-Dimethylaminoisopropyl chloride hydrochloride 4584-49-0
Price
US $100.00-70.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-16

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