5α-Cholestane Property

Melting point:

78-80 °C

Boiling point:

250 °C (1 mmHg)

Density 

0.9090

refractive index 

1.4887

storage temp. 

room temp

form 

Crystalline Powder

color 

White

Merck 

13,2219

BRN 

2051806

LogP

11.945 (est)

CAS DataBase Reference

481-21-0(CAS DataBase Reference)

EPA Substance Registry System

Cholestane, (5.alpha.)- (481-21-0)

Safety

Hazard Codes 

Xn

Risk Statements 

22-38-40-48/20/22-67-36/38-20-63

Safety Statements 

24/25-36/37-26

RIDADR 

UN 1888 6.1/PG 3

WGK Germany 

3

HS Code 

29021990

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

5α-Cholestane Chemical Properties,Usage,Production

Description

5α-Cholestane is a sterol that has been found in dust samples from urban and rural paved and agricultural and public unpaved roads. It has been used as an internal standard for the quantification of phytosterols by HPLC-MS/MS and fecal sterols by GC-FID and GC-MS.

Chemical Properties

WHITE CRYSTALLINE POWDER

Uses

5α-Cholestane was used as standard in cholesterol analysis by GC and HPLC.

Uses

α-Cholestane is the trans-decalin homolog of Coprostane.

Definition

ChEBI: The 5alpha-stereoisomer of cholestane.

Biochem/physiol Actions

5α-Cholestane is a sterol produced endogenously from cholesterol and has been isolated from human feces. It is derived from cholesterol by the action of intestinal microorganisms. Derivatives of 5α-cholestane in plants are called Brassinosteroids that selectively activate the PPI3K/Akt pathway.

Purification Methods

Crystallise 5-cholestane from Et2O/EtOH or EtOAc. [Ruzicka et al. Helv Chim Acta 16 327 1933, Beilstein 5 III 1132, 5 IV 1227.]