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GW 842166X

Product Name
GW 842166X
CAS No.
666260-75-9
Chemical Name
GW 842166X
Synonyms
CS-631;GW 842166;GW 842166X;GW842166X ，S2778;GW842166X;GW 842166;GW 842166X USP/EP/BP;GW842166X/GW-842166X;GW842166X, 10 mM in DMSO;2-(2,4-dichloroanilino)-N-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide;2-(2,4-dichlorophenylamino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide
CBNumber
CB32455643
Molecular Formula
C18H17Cl2F3N4O2
Formula Weight
449.25
MOL File
666260-75-9.mol
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GW 842166X Property

storage temp. 
Store at -20°C
solubility 
DMF:20.0(Max Conc. mg/mL);44.52(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.56(Max Conc. mM)
DMSO:37.77(Max Conc. mg/mL);84.07(Max Conc. mM)
Ethanol:0.3(Max Conc. mg/mL);0.67(Max Conc. mM)
form 
Powder
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10010372
Product name
GW 842166X
Purity
≥98%
Packaging
1mg
Price
$22
Updated
2024/03/01
Cayman Chemical
Product number
10010372
Product name
GW 842166X
Purity
≥98%
Packaging
5mg
Price
$95
Updated
2024/03/01
Cayman Chemical
Product number
10010372
Product name
GW 842166X
Purity
≥98%
Packaging
10mg
Price
$168
Updated
2024/03/01
Cayman Chemical
Product number
10010372
Product name
GW 842166X
Purity
≥98%
Packaging
25mg
Price
$319
Updated
2024/03/01
TRC
Product number
G931520
Product name
GW-842166X
Packaging
25mg
Price
$370
Updated
2021/12/16
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GW 842166X Chemical Properties,Usage,Production

Description

The peripheral cannabinoid (CB2) receptor is a G protein-coupled receptor (GPCR) that is localized predominantly in immune cells, monocytes, macrophages, and in several peripheral organs and binds the active component of cannabis, Δ9-tetrahydrocannabinol, as well as anandamide, an endogenous CB receptor ligand. GW 842166X is a peripheral cannabinoid (CB2) receptor agonist with ED50 values of 91 and 63 nM in rat and human, respectively. When administered orally to rats in the Freund’s complete adjuvant (FCA) model of inflammatory pain, GW 842166X is highly potent with an ED50 value of 0.1 mg/kg and full reversal of hyperalgesia at 0.3 mg/kg.

Uses

GW-842166X is pyrimidine ester based compound that is known as a highly selective CB2 receptor agonist for the treatment of inflammatory and neuropathic pain.

Definition

ChEBI: 5-pyrimidinecarboxamide, 2-[(2,4-dichlorophenyl)amino]-n-[(tetrahydro-2h-pyran-4-yl)methyl]-4-(trifluoromethyl)- is a dichlorobenzene.

in vivo

GW842166X has an oral ED50 of 0.1 mg/kg in the rat FCA model of inflammatory pain and shows full reversal of hyperalgesia at 0.3 mg/kg. The blood concentrations of GW842166X in experiments are 30 nM (0.03 mg/kg), 130 nM (0.1 mg/kg), and 370 nM (0.3 mg/ kg) 1 h after dosing. After dosing for 4 days in the FCA model, no statistical difference in antihyperalgesic response is observed on day 4 relative to day 1, indicating that tolerance does not occur[1].

References

[1] GERARD M. P. GIBLIN. Discovery of 2-[(2,4-Dichlorophenyl)amino]-N-[(tetrahydro- 2H-pyran-4-yl)methyl]-4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a Selective CB2 Receptor Agonist for the Treatment of Inflammatory Pain[J]. Journal of Medicinal Chemistry, 2007, 50 11: 2597-2600. DOI: 10.1021/jm061195+
[2] RACHEL RIBEIRO . Involvement of ERK1/2, cPLA2 and NF-κB in microglia suppression by cannabinoid receptor agonists and antagonists[J]. Prostaglandins & other lipid mediators, 2013, 100: Pages 1-14. DOI: 10.1016/j.prostaglandins.2012.11.003

GW 842166X Preparation Products And Raw materials

Raw materials

Preparation Products

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GW 842166X Suppliers

Canada 1 China 102 United States 12 Global 115
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
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96815
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Dalian Meilun Biotech Co., Ltd.
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0411-62910999 13889544652
Email
sales@meilune.com
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China
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4747
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58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
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25003
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MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
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4861
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58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
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58
ShangHai KenEn Chemical Technology Co., Ltd.
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13120367189
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021-50315529
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mychess007@163.com
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China
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1994
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55
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
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027-59599241
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1400878000@qq.com
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China
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9858
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LETOPHARM LIMITED
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+86-21-5821 5861
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+86-21-5106 2861
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sales@letopharm.com
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China
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2384
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58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
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55
Codow Chemical Co.,Ltd.
Tel
18620099427
Fax
+86-20-62619665
Email
amy@howeipharm.com
Country
China
ProdList
6687
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55
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View Lastest Price from GW 842166X manufacturers

Career Henan Chemical Co
Product
GW842166X 666260-75-9
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-10

666260-75-9, GW 842166XRelated Search:

CHLOROPHENYLSILANE Phenylsilane Benzeneruthenium(II) chloride dimer Phenyl dichlorophosphate Phenyltrichlorosilane WY-14643 SIRTINOL Rimonabant DAPT 17-DMAG GW 842166X

  • GW 842166X
  • GW 842166
  • GW842166X/GW-842166X
  • 2-(2,4-Dichlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic acid [(tetrahydropyran-4-yl)methyl]amide
  • 2-(2,4-dichlorophenylamino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide
  • 2-(2,4-dichloroanilino)-N-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide
  • GW842166X;GW 842166
  • CS-631
  • 5-Pyrimidinecarboxamide, 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-
  • GW 842166X USP/EP/BP
  • GW842166X, 10 mM in DMSO
  • GW842166X ，S2778
  • 666260-75-9
  • C18H17Cl2F3N4O2
  • Inhibitors