GW 842166X

ChemicalBook > CAS DataBase List > GW 842166X

Product Name: GW 842166X
CAS No.: 666260-75-9
Chemical Name: GW 842166X
Synonyms: CS-631;GW 842166;GW 842166X;GW842166X;GW 842166;GW842166X/GW-842166X;GW 842166X USP/EP/BP;2-(2,4-dichloroanilino)-N-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide;2-(2,4-dichlorophenylamino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide;2-(2,4-Dichlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic acid [(tetrahydropyran-4-yl)methyl]amide;5-Pyrimidinecarboxamide, 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-
CBNumber: CB32455643
Molecular Formula: C18H17Cl2F3N4O2
Formula Weight: 449.25
MOL File: 666260-75-9.mol

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GW 842166X Property

storage temp.: Store at -20°C
solubility: DMF:20.0(Max Conc. mg/mL);44.52(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.56(Max Conc. mM)
DMSO:37.77(Max Conc. mg/mL);84.07(Max Conc. mM)
Ethanol:0.3(Max Conc. mg/mL);0.67(Max Conc. mM)
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10010372
Product name: GW 842166X
Purity: ≥98%
Packaging: 1mg
Price: $22
Updated: 2024/03/01

Cayman Chemical

Product number: 10010372
Product name: GW 842166X
Purity: ≥98%
Packaging: 5mg
Price: $95
Updated: 2024/03/01

Cayman Chemical

Product number: 10010372
Product name: GW 842166X
Purity: ≥98%
Packaging: 10mg
Price: $168
Updated: 2024/03/01

Cayman Chemical

Product number: 10010372
Product name: GW 842166X
Purity: ≥98%
Packaging: 25mg
Price: $319
Updated: 2024/03/01

TRC

Product number: G931520
Product name: GW-842166X
Packaging: 25mg
Price: $370
Updated: 2021/12/16

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GW 842166X Chemical Properties,Usage,Production

Description

The peripheral cannabinoid (CB₂) receptor is a G protein-coupled receptor (GPCR) that is localized predominantly in immune cells, monocytes, macrophages, and in several peripheral organs and binds the active component of cannabis, Δ⁹-tetrahydrocannabinol, as well as anandamide, an endogenous CB receptor ligand. GW 842166X is a peripheral cannabinoid (CB₂) receptor agonist with ED₅₀ values of 91 and 63 nM in rat and human, respectively. When administered orally to rats in the Freund’s complete adjuvant (FCA) model of inflammatory pain, GW 842166X is highly potent with an ED₅₀ value of 0.1 mg/kg and full reversal of hyperalgesia at 0.3 mg/kg.

Uses

GW-842166X is pyrimidine ester based compound that is known as a highly selective CB2 receptor agonist for the treatment of inflammatory and neuropathic pain.

Definition

ChEBI: 5-pyrimidinecarboxamide, 2-[(2,4-dichlorophenyl)amino]-n-[(tetrahydro-2h-pyran-4-yl)methyl]-4-(trifluoromethyl)- is a dichlorobenzene.

GW 842166X Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from GW 842166X manufacturers

Career Henan Chemical Co

Product: GW842166X 666260-75-9
Price: US $1.00/g
Min. Order: 1g
Purity: 95-99%
Supply Ability: 1ton
Release date: 2020-01-10

666260-75-9, GW 842166XRelated Search:

CHLOROPHENYLSILANE 97 Phenylsilane Benzeneruthenium(II) chloride dimer Phenyl dichlorophosphate Phenyltrichlorosilane WY-14643 SIRTINOL Rimonabant DAPT 17-DMAG GW 842166X

GW 842166X

GW 842166

GW842166X/GW-842166X

2-(2,4-Dichlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic acid [(tetrahydropyran-4-yl)methyl]amide

2-(2,4-dichlorophenylamino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide

2-(2,4-dichloroanilino)-N-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide

GW842166X;GW 842166

CS-631

5-Pyrimidinecarboxamide, 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-

GW 842166X USP/EP/BP

666260-75-9

C18H17Cl2F3N4O2

Inhibitors