CAL-101
- Product Name
- CAL-101
- CAS No.
- 870281-82-6
- Chemical Name
- CAL-101
- Synonyms
- Idelalisib(CAL-101);-101;CS-34;GS1101;AL-101;CAL-11;CAL-101;CAL-101 1KG;CAL101,CAL-101;CAL-101, >=98%
- CBNumber
- CB32538915
- Molecular Formula
- C22H18FN7O
- Formula Weight
- 415.42
- MOL File
- 870281-82-6.mol
CAL-101 Property
- Melting point:
- 250-252oC
- Boiling point:
- 733.4±70.0 °C(Predicted)
- Density
- 1.47
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (>25 mg/ml)
- form
- White solid.
- pka
- 10.00±0.10(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety
- Safety Statements
- V
- HS Code
- 29399990
- Hazardous Substances Data
- 870281-82-6(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P314Get medical advice/attention if you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 15279
- Product name
- CAL-101
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 15279
- Product name
- CAL-101
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $63
- Updated
- 2024/03/01
- Product number
- 15279
- Product name
- CAL-101
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $107
- Updated
- 2024/03/01
- Product number
- 15279
- Product name
- CAL-101
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $164
- Updated
- 2024/03/01
- Product number
- C124800
- Product name
- CAL-101
- Packaging
- 100mg
- Price
- $285
- Updated
- 2021/12/16
CAL-101 Chemical Properties,Usage,Production
Description
Idelalisib (CAS 870281-82-6) is a potent (IC50 = 2.5nM) and selective (IC50’s: PI3Ka = 820nM, PI3Kb = 565nM, PI3Kg = 89nM) PI3Kd inhibitor.1,2 Useful clinical agent for the treatment of various blood cancers. Idelalisib attenuates regulatory T cells (Treg) but not conventional T cells (Tconv) resulting in a significant increase in tumor-infiltrating antigen-specific CD8 T cells in a murine lung cancer model.3 Conversely, systemic PI3Kd inactivation antagonized anti-CTLA-4 and anti-PD-L1 treatment.4 Others have found that Idelalisib minimally influenced rituximab- and obinutuzumab-mediated Ab-dependent cellular cytotoxicity in human lymphoma cells.5
Uses
CAL-101 is a PI3K/mTOR pathway inhibitor used in the treatment of myeloid leukemia through sensitizing the cells to combatting drugs. Potent PI3K-p110-delta inhibitor.
Definition
ChEBI: A member of the class of quinazolines that is 5-fluoro-3-phenylquinazolin-4-one in which the hydrogen at position 2 is replaced by a (1S)-1-(3H-purin-6-ylamino)propyl group. used for for the treatment of refractory indol nt non-Hodgkin's lymphoma and relapsed chronic lymphocytic leukemia.
target
p110δ
storage
Store at -20°C
References
1) Herman?et al. (2010), Phosphatidylinositol 2-kinase-d inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals; Blood?116 2078 2) Lannutti?et al. (2011), CAL-101, a p110d selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability; Blood 117 591 3) Ahmad?et al. (2017), Differential PI3Kd Signaling in CD4+ T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy; Cancer Res. 77 1892 4) Lim?et al. (2018), Phosphoinositide 3-kinase d inhibition promotes antitumor responses but antagonizes checkpoint inhibitors; JCI Insight 3 e120626 5) Palazzo?et al.?(2018),?The PI3Kd-Selective Inhibitor Idelalisib Minimally Interferes with Immune Effector Function Mediated by Rituximab or Obinutuzumab and Significantly Augment B Cell Depletion In Vivo; J.Immunol. 200 2304
CAL-101 Preparation Products And Raw materials
Raw materials
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View Lastest Price from CAL-101 manufacturers
- Product
- CAL-101 870281-82-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-09
- Product
- Idelalisib 870281-82-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
- Product
- CAL-101 870281-82-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10