ChemicalBook > CAS DataBase List > CAL-101

CAL-101

Product Name
CAL-101
CAS No.
870281-82-6
Chemical Name
CAL-101
Synonyms
Idelalisib(CAL-101);-101;CS-34;GS1101;AL-101;CAL-11;CAL-101;CAL-101 1KG;CAL101,CAL-101;CAL-101, >=98%
CBNumber
CB32538915
Molecular Formula
C22H18FN7O
Formula Weight
415.42
MOL File
870281-82-6.mol
More
Less

CAL-101 Property

Melting point:
250-252oC
Boiling point:
733.4±70.0 °C(Predicted)
Density 
1.47
storage temp. 
-20°C
solubility 
Soluble in DMSO (>25 mg/ml)
form 
White solid.
pka
10.00±0.10(Predicted)
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
InChIKey
IFSDAJWBUCMOAH-HNNXBMFYSA-N
SMILES
N1C2=C(C(F)=CC=C2)C(=O)N(C2=CC=CC=C2)C=1[C@@H](NC1=C2C(=NC=N1)NC=N2)CC
More
Less

Safety

Safety Statements 
V
HS Code 
29399990
Hazardous Substances Data
870281-82-6(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
15279
Product name
CAL-101
Purity
≥98%
Packaging
5mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
15279
Product name
CAL-101
Purity
≥98%
Packaging
10mg
Price
$63
Updated
2024/03/01
Cayman Chemical
Product number
15279
Product name
CAL-101
Purity
≥98%
Packaging
25mg
Price
$107
Updated
2024/03/01
Cayman Chemical
Product number
15279
Product name
CAL-101
Purity
≥98%
Packaging
50mg
Price
$164
Updated
2024/03/01
TRC
Product number
C124800
Product name
CAL-101
Packaging
100mg
Price
$285
Updated
2021/12/16
More
Less

CAL-101 Chemical Properties,Usage,Production

Description

Idelalisib (CAS 870281-82-6) is a potent (IC50 = 2.5nM) and selective (IC50’s: PI3Ka = 820nM, PI3Kb = 565nM, PI3Kg = 89nM) PI3Kd inhibitor.1,2 Useful clinical agent for the treatment of various blood cancers. Idelalisib attenuates regulatory T cells (Treg) but not conventional T cells (Tconv) resulting in a significant increase in tumor-infiltrating antigen-specific CD8 T cells in a murine lung cancer model.3 Conversely, systemic PI3Kd inactivation antagonized anti-CTLA-4 and anti-PD-L1 treatment.4 Others have found that Idelalisib minimally influenced rituximab- and obinutuzumab-mediated Ab-dependent cellular cytotoxicity in human lymphoma cells.5

Uses

CAL-101 is a PI3K/mTOR pathway inhibitor used in the treatment of myeloid leukemia through sensitizing the cells to combatting drugs. Potent PI3K-p110-delta inhibitor.

Definition

ChEBI: A member of the class of quinazolines that is 5-fluoro-3-phenylquinazolin-4-one in which the hydrogen at position 2 is replaced by a (1S)-1-(3H-purin-6-ylamino)propyl group. used for for the treatment of refractory indol nt non-Hodgkin's lymphoma and relapsed chronic lymphocytic leukemia.

in vitro

CAL-101 (Idelalisib) is a highly selective and potent p110δ inhibitor (EC50=8 nM). Greater selectivity (400- to 4000-fold) is seen against related kinases C2β, hVPS34, DNA-PK, and mTOR, whereas no activity is observed against a panel of 402 diverse kinases at 10 μM. CAL-101 reduces PDGF-induced pAkt by only 25% at 10 μM. Idelalisib (CAL-101) inhibits LPA-induced pAkt with an EC50 of 1.9 μM. Idelalisib (CAL-101) blocks Fc?RI p110δ-mediated CD63 expression with an EC50 of 8 nM, whereas formyl-methionyl-leucyl-phenylalanine activation of p110γ is inhibited with an EC50 of 3 μM. Thus, CAL-101 has 240- to 2500-fold selectivity in cell-based assays for p110δ over the other class I PI3K isoforms. CAL-101Idelalisib (CAL-101)-induced apoptosis of chronic lymphocytic leukemia (CLL) cells is significant compared with vehicle treatment alone (P<0.001). Idelalisib (CAL-101) induces selective cytotoxicity in CLL cells independent of IgVH mutational status or interphase cytogenetics.

in vivo

A significant reduction is observed in the CD11b+Ly6G+ neutrophils from brain homogenates of bothp110δD910A/D910A mice and Idelalisib (CAL-101) (40 mg/kg, i.v.) post-treated mice.

target

p110δ

storage

Store at -20°C

References

1) Herman?et al. (2010), Phosphatidylinositol 2-kinase-d inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals; Blood?116 2078 2) Lannutti?et al. (2011), CAL-101, a p110d selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability; Blood 117 591 3) Ahmad?et al. (2017), Differential PI3Kd Signaling in CD4+ T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy; Cancer Res. 77 1892 4) Lim?et al. (2018), Phosphoinositide 3-kinase d inhibition promotes antitumor responses but antagonizes checkpoint inhibitors; JCI Insight 3 e120626 5) Palazzo?et al.?(2018),?The PI3Kd-Selective Inhibitor Idelalisib Minimally Interferes with Immune Effector Function Mediated by Rituximab or Obinutuzumab and Significantly Augment B Cell Depletion In Vivo; J.Immunol. 200 2304

CAL-101 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

CAL-101 Suppliers

China 251 China Hong Kong 1 India 6 Japan 1 United Kingdom 3 United States 27 Global 289
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd
Tel
17316404525
Email
209533805@qq.com
Country
China
ProdList
9765
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
Shanghai Feibo Chemical Technology Co., Ltd
Tel
021-58955608,2250286 15921236618
Email
blinkzeng@gmail.com
Country
China
ProdList
522
Advantage
62
More
Less

View Lastest Price from CAL-101 manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
CAL-101 870281-82-6
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99% HPLC
Supply Ability
10000
Release date
2024-09-22
Hebei Yanxi Chemical Co., Ltd.
Product
CAL-101 870281-82-6
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-09
PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
Product
Idelalisib 870281-82-6
Price
US $0.00/kg
Min. Order
1kg
Purity
98% HPLC
Supply Ability
500 kgs
Release date
2024-05-13

870281-82-6, CAL-101Related Search:

AZD-6244 ARRY-334543 Dovitinib Volitinib 2-Amino-6-fluorobenzoic acid (S)-2-(1-aMinopropyl)-5-fluoro-3-phenylquinazolin-4(3H)-one BOC-ABU-OH (S)-tert-butyl (1-(5-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)propyl)carbaMate 2-Fluoro-6-nitro-N-phenylbenzamide Everolimus Bortezomib BKM120 (NVP-BKM120, Buparlisib) Pictilisib IPI 145 Ibrutinib CO-1686 Momelotinib 790299-79-5

  • CAL101,CAL-101
  • CAL-101
  • GS1101
  • CAL-101 (GS-1101)
  • 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone
  • CAL-101 (Idelalisib, GS-1101)
  • (S)-2-(1-((9H-Purin-6-yl)aMino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
  • Idelalisib(CAL-101)
  • 4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(1H-purin-6-ylaMino)propyl]-
  • 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]quinazolin-4-one
  • 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone CAL-101 (Idelalisib, GS-1101)
  • CAL-101 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone
  • CAL-101(IDELALISIB) AL-101
  • CAL-101(IDELALISIB)
  • AL-101
  • CAL-101, >=98%
  • IDELALISIB; CAL-101; GS-1101; GS 1101; GS1101;CAL101
  • CS-34
  • Idelalisib, CAL-101, GS-1101
  • 5-Fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone
  • CAL-101 1KG
  • CAL-11
  • Idelalisib (This product is only available in Japan.)
  • CAL-101, 99%, a selective p110δ inhibitor
  • 4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-
  • -101
  • CAL-101 USP/EP/BP
  • Idelalisib (CAL101, Zydelig, GS1101)
  • 5-Fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)propyl]-4(3H)-qui...
  • Idelalisib,PI3K,CAL101,CAL 101,GS 1101,Phosphoinositide 3-kinase,Autophagy,Inhibitor,inhibit,GS1101
  • (S)-2-(1-((9H-Purin-6-yl)ami)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
  • Dabrafenib Mesilate
  • (S)-2-(1-((7H-purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
  • 870281-82-6
  • 10870281-82-6
  • C22H18FN7O
  • Akt
  • mTOR
  • PI3K
  • API
  • API
  • Inhibitors
  • Inhibitor