ChemicalBook > CAS DataBase List > TAE226 (NVP-TAE226)

TAE226 (NVP-TAE226)

Product Name
TAE226 (NVP-TAE226)
CAS No.
761437-28-9
Chemical Name
TAE226 (NVP-TAE226)
Synonyms
TAE226;CS-1694;NVP-TAE 226;TAE-226, >98%;TAE226 (NVP-TAE226);NVP-TAE226 (TAE-226;TAE226 (NVP-TAE226), >98%;NVP-TAE 226, 10 mM in DMSO;TAE226 (NVP-TAE226) ，S2820;TAE226 (NVP-TAE226) USP/EP/BP
CBNumber
CB32589634
Molecular Formula
C23H25ClN6O3
Formula Weight
468.94
MOL File
761437-28-9.mol
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TAE226 (NVP-TAE226) Property

Density 
1.349
storage temp. 
Store at -20°C
solubility 
≥23.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form 
solid
pka
14.57±0.46(Predicted)
color 
White to khaki
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17685
Product name
NVP-TAE226
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
17685
Product name
NVP-TAE226
Purity
≥98%
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
17685
Product name
NVP-TAE226
Purity
≥98%
Packaging
10mg
Price
$321
Updated
2024/03/01
Cayman Chemical
Product number
17685
Product name
NVP-TAE226
Purity
≥98%
Packaging
25mg
Price
$692
Updated
2024/03/01
TRC
Product number
N925910
Product name
NVP-TAE226
Packaging
5mg
Price
$255
Updated
2021/12/16
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TAE226 (NVP-TAE226) Chemical Properties,Usage,Production

Description

NVP-TAE226 is an inhibitor of focal adhesion kinase (FAK; IC50 = 5.5 nM) and the related proline-rich tyrosine kinase 2-β (PYK2β; IC50 = 5 nM). It can also inhibit the insulin-like growth factor 1 receptor (IC50 = 0.16 μM) as well as the activity of its downstream target genes such as MAPK and Akt. NVP-TAE226 has been shown to inhibit glioma and ovarian tumor growth in in vivo tumor models.

Uses

NVP-TAE 226 is FAK and IGF-IR inhibitor. It can be used in biological study and therapeutic use of TAE226, a bis-?anilino pyrimidine compound, inhibits the egfr-?mutant kinase including T790M mutant to show anti-?tumor effect on EGFR-?mutant non-?small cell lung cancer cells.

Definition

ChEBI: 2-[[5-chloro-2-[2-methoxy-4-(4-morpholinyl)anilino]-4-pyrimidinyl]amino]-N-methylbenzamide is a member of morpholines.

in vivo

Treatment with NVP-TAE 226 (TAE226) at 50 or 75 mg/kg extends the median survival of U87 xenograft animals by 6 and 7 days, respectively (P=0.084 and P=0.042, respectively, compared with vehicle-treated animals). However, NVP-TAE 226 treatment of LN229-engrafted animals significantly prolongs their median survival by 19 days (P<0.004 for both dosages, compared with vehicle-treated animals)[1].

target

PYK2

References

[1]. liu, t.j., et al., inhibition of both focal adhesion kinase and insulin-like growth factor-i receptor kinase suppresses glioma proliferation in vitro and in vivo. mol cancer ther, 2007. 6(4): p. 1357-67.
[2]. plaza-menacho, i., et al., focal adhesion kinase (fak) binds ret kinase via its ferm domain, priming a direct and reciprocal ret-fak transactivation mechanism. j biol chem, 2011. 286(19): p. 17292-302.

TAE226 (NVP-TAE226) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TAE226 (NVP-TAE226) manufacturers

Career Henan Chemical Co
Product
TAE226 (NVP-TAE226) 761437-28-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20kg
Release date
2019-09-05

761437-28-9, TAE226 (NVP-TAE226)Related Search:

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  • NVP-TAE 226
  • TAE226
  • TAE226 (NVP-TAE226)
  • 2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)-amino)pyrimidin-4-yl)amino)-N-methylbenzamide
  • Benzamide, 2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-
  • NVP-TAE 226 2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide
  • 2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide
  • TAE226 (NVP-TAE226), >98%
  • TAE-226, >98%
  • TAE226; TAE-226;TAE 226;NVPTAE226
  • CS-1694
  • TAE226 (NVP-TAE226) USP/EP/BP
  • NVP-TAE 226, 10 mM in DMSO
  • TAE226 (NVP-TAE226) ，S2820
  • NVP-TAE226 (TAE-226
  • 2-({5-chloro-2-[2-methoxy-4-(4-morpholinyl)anilino]-4-pyrimidinyl}amino)-N-methylbenzamide
  • 761437-28-9
  • Inhibitors