TAE226 (NVP-TAE226)

Product Name: TAE226 (NVP-TAE226)
CAS No.: 761437-28-9
Chemical Name: TAE226 (NVP-TAE226)
Synonyms: TAE226;CS-1694;NVP-TAE 226;TAE-226, >98%;TAE226 (NVP-TAE226);TAE226 (NVP-TAE226), >98%;TAE226 (NVP-TAE226) USP/EP/BP;TAE226; TAE-226;TAE 226;NVPTAE226;2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)-amino)pyrimidin-4-yl)amino)-N-methylbenzamide;2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide
CBNumber: CB32589634
Molecular Formula: C23H25ClN6O3
Formula Weight: 468.94
MOL File: 761437-28-9.mol

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TAE226 (NVP-TAE226) Property

Density: 1.349
storage temp.: Store at -20°C
solubility: ≥23.45 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
pka: 14.57±0.46(Predicted)
color: White to khaki

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17685
Product name: NVP-TAE226
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 17685
Product name: NVP-TAE226
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 17685
Product name: NVP-TAE226
Purity: ≥98%
Packaging: 10mg
Price: $321
Updated: 2024/03/01

Cayman Chemical

Product number: 17685
Product name: NVP-TAE226
Purity: ≥98%
Packaging: 25mg
Price: $692
Updated: 2024/03/01

TRC

Product number: N925910
Product name: NVP-TAE226
Packaging: 5mg
Price: $255
Updated: 2021/12/16

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TAE226 (NVP-TAE226) Chemical Properties,Usage,Production

Description

NVP-TAE226 is an inhibitor of focal adhesion kinase (FAK; IC₅₀ = 5.5 nM) and the related proline-rich tyrosine kinase 2-β (PYK2β; IC₅₀ = 5 nM). It can also inhibit the insulin-like growth factor 1 receptor (IC₅₀ = 0.16 μM) as well as the activity of its downstream target genes such as MAPK and Akt. NVP-TAE226 has been shown to inhibit glioma and ovarian tumor growth in in vivo tumor models.

Uses

NVP-TAE 226 is FAK and IGF-IR inhibitor. It can be used in biological study and therapeutic use of TAE226, a bis-?anilino pyrimidine compound, inhibits the egfr-?mutant kinase including T790M mutant to show anti-?tumor effect on EGFR-?mutant non-?small cell lung cancer cells.

Definition

ChEBI: 2-[[5-chloro-2-[2-methoxy-4-(4-morpholinyl)anilino]-4-pyrimidinyl]amino]-N-methylbenzamide is a member of morpholines.

target

PYK2

References

[1]. liu, t.j., et al., inhibition of both focal adhesion kinase and insulin-like growth factor-i receptor kinase suppresses glioma proliferation in vitro and in vivo. mol cancer ther, 2007. 6(4): p. 1357-67.
[2]. plaza-menacho, i., et al., focal adhesion kinase (fak) binds ret kinase via its ferm domain, priming a direct and reciprocal ret-fak transactivation mechanism. j biol chem, 2011. 286(19): p. 17292-302.

TAE226 (NVP-TAE226) Preparation Products And Raw materials

Raw materials

Preparation Products

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TAE226 (NVP-TAE226) Suppliers

China 87 India 1 United Kingdom 1 United States 12 Global 101

Shanghai Boyle Chemical Co., Ltd.

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Haoyuan Chemexpress Co., Ltd.

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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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View Lastest Price from TAE226 (NVP-TAE226) manufacturers

Career Henan Chemical Co

Product: TAE226 (NVP-TAE226) 761437-28-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

761437-28-9, TAE226 (NVP-TAE226)Related Search:

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NVP-TAE 226

TAE226

TAE226 (NVP-TAE226)

2-((5-Chloro-2-((2-methoxy-4-morpholinophenyl)-amino)pyrimidin-4-yl)amino)-N-methylbenzamide

Benzamide, 2-[[5-chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methyl-

NVP-TAE 226 2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide

2-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-N-methylbenzamide

TAE226 (NVP-TAE226), >98%

TAE-226, >98%

TAE226; TAE-226;TAE 226;NVPTAE226

CS-1694

TAE226 (NVP-TAE226) USP/EP/BP

761437-28-9

Inhibitors