2-Amino-6-chloro-4-pyrimidinol

Product Name: 2-Amino-6-chloro-4-pyrimidinol
CAS No.: 1194-21-4
Chemical Name: 2-Amino-6-chloro-4-pyrimidinol
Synonyms: AKOS 92811;TIMTEC-BB SBB004114;6-Chloroisocytosine;WLN: T6N CNJ BZ DQ FG;Methylphenylcyclicsiloxane;2-amino-6-chloro-4-pyrimidino;2-AMino-6-chloropyriMidin-4-ol;2-AMINO-4-CHLORO-6-PYRIMIDINOL;2-amino-6-chloro-4-pyrimidinol;2-Amino-6-chloro-4-pyrimidinone
CBNumber: CB3266014
Molecular Formula: C4H4ClN3O
Formula Weight: 145.55
MOL File: 1194-21-4.mol

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2-Amino-6-chloro-4-pyrimidinol Property

Melting point:: 252 °C (dec.)(lit.)
Boiling point:: 259.1±50.0 °C(Predicted)
Density: 1.7910 (rough estimate)
refractive index: 1.4510 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Sparingly)
form: Solid
pka: 7.49±0.50(Predicted)
color: Pale Yellow
Stability:: Hygroscopic
InChI: InChI=1S/C4H4ClN3O/c5-2-1-3(9)8-4(6)7-2/h1H,(H3,6,7,8,9)
InChIKey: VBWACOJLJYUFKJ-UHFFFAOYSA-N
SMILES: C1(N)NC(Cl)=CC(=O)N=1
CAS DataBase Reference: 1194-21-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22-20/21/22
Safety Statements: 26-36-36/37-24/25
WGK Germany: 3
RTECS: UW5995000
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A1109
Product name: 2-Amino-4-chloro-6-hydroxypyrimidine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $85
Updated: 2025/07/31

TCI Chemical

Product number: A1109
Product name: 2-Amino-4-chloro-6-hydroxypyrimidine
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $285
Updated: 2025/07/31

TRC

Product number: A603195
Product name: 2-Amino-6-chloro-4-pyrimidinol
Packaging: 5g
Price: $130
Updated: 2021/12/16

Apolloscientific

Product number: OR49059
Product name: 2-Amino-6-chloro-pyrimidin-4-ol
Packaging: 5g
Price: $135
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA35262
Product name: 2-Amino-6-chloropyrimidin-4(3h)-one
Packaging: 5G
Price: $190
Updated: 2021/12/16

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2-Amino-6-chloro-4-pyrimidinol Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

2-?Amino-?6-?chloro-?4-?pyrimidinol is used to prepare O- and N-phosphonomethoxyalkyl pyrimidines with antiviral activities. It is also used to synthesize (±)?-?9-?[[(Z)?-?2-?(hydroxymethyl)?cyclopropyl]?methyl]?guanine with antiherpetic activities.

Synthesis

56-05-3

1194-21-4

General procedure for the synthesis of 2-amino-6-chloro-4-hydroxypyrimidines from 2-amino-4,6-dichloropyrimidines: to a suspension of 4,6-dichloropyrimidin-2-amine (21.2 g, 129.27 mmol) in 200 mL of aqueous 1N NaOH was added solid NaOH (4 g, 100.00 mmol) in batches. The reaction mixture was heated to reflux for 5 hours. After completion of the reaction, the mixture was cooled to room temperature in an ice water bath. The pH was slowly adjusted to 5-6 with aqueous CH3COOH. the reaction mixture was filtered and the precipitate collected. The solid product was washed with deionized water and subsequently dried in an oven under reduced pressure to give 17 g (86% yield) of 2-amino-6-chloro-4-hydroxypyrimidine as a white solid.

References

[1] Chemistry (Weinheim an der Bergstrasse, Germany), 2002, vol. 8, # 1, p. 293 - 301
[2] Organic Letters, 2009, vol. 11, # 1, p. 61 - 64
[3] Patent: WO2009/139834, 2009, A1. Location in patent: Page/Page column 93
[4] Journal of the Chemical Society, 1951, p. 3,6
[5] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 8, p. 1081 - 1083

2-Amino-6-chloro-4-pyrimidinol Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-6-chloro-4-pyrimidinol Suppliers

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View Lastest Price from 2-Amino-6-chloro-4-pyrimidinol manufacturers

Dideu Industries Group Limited

Product: 2-Amino-6-chloro-4-pyrimidinol 1194-21-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-09

Career Henan Chemical Co

Product: 2-Amino-6-chloro-4-pyrimidinol 1194-21-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-24

1194-21-4, 2-Amino-6-chloro-4-pyrimidinolRelated Search:

2-Amino-5-hydroxypyrimidine Glycine 2-Aminopyrimidine 4-Hydroxypyrimidine ALTRENOGEST Glucosamine 6-Aminocaproic acid Isocytosine Acetaminophen Sulfamic acid EC 2.6.1.2 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL Tris(hydroxymethyl)aminomethane 2-Amino-4-chloro-6-methoxypyrimidine Chlorimuron-ethyl 2-AMINO-6-CHLORO-4-PYRIMIDINOL HYDRATE, 95 2-AMINO-4-CHLORO-6-HYDROXY-5-NITROPYRIMIDINE 2-AMINO-4-CHLORO-6-ETHOXYPYRIMIDINE

2-aMino-6-chloropyriMidine-4,5-diol

AKOS 92811

2-AMino-6-chloropyriMidin-4-ol

2-AMino-6-Chloro-4-PyriMidinol Monohydr

2-AMINO-4-HYDROXY-6-CHLOROPYRIMIDINE

2-AMINO-6-CHLORO-4-HYDROXYPYRIMIDINE

2-AMINO-4-CHLORO-6-HYDROXYPYRIMIDINE

2-AMINO-4-CHLORO-6-PYRIMIDINOL

TIMTEC-BB SBB004114

4(1H)-Pyrimidinone,2-amino-6-chloro-

Methylphenylcyclicsiloxane

2-Amino-6-chloro-4-pyrimidinone

2-amino-6-chloro-4(1h)-pyrimidinon

2-amino-6-chloro-4-pyrimidino

WLN: T6N CNJ BZ DQ FG

2-amino-6-chloropyrimidin-4(1H)-one

2-amino-6-chloro-4-pyrimidinol

2-amino-6-chloropyrimidin-4-ol hydrate

4(1H)-Pyrimidinone, 2-amino-6-chloro- (9CI)

4-Pyrimidinol, 2-amino-6-chloro.

2-AMINO-6-CHLORO-4-PYRIMIDINOL HYDRATE PURUM 98%

2-AMINO-6-CHLORO-4-PYRIMIDINOL MONOHYDRATE 95%

2-amino-6-chloro-1H-pyrimidin-4-one

2-azanyl-6-chloro-1H-pyrimidin-4-one

2-amino-6-chloropyrimidin-4(5H)-one

2-amino-6-chloro-3H-pyrimidine-4-one

2-AMino-6-chloropyriMidin-4(3H)-one ,97%

2-Amino-6-chloro-4(1H)-pyrimidinone

2-Amino-6-chloro-4(3H)-pyrimidinone

6-Chloroisocytosine

2-Amino-4-chloro-6-hydroxypyrimidine&gt

2-Amino-6-chloro-4-pyrimidinol ISO 9001：2015 REACH

2-Amino-6-chloropyrimidin-4(3H)-one, 95+%

1194-21-4

C4H4ClN2O

HETERO CHLORIDE

Building Blocks

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyrimidines

PYRIMIDINE