ChemicalBook > CAS DataBase List > WH-4-023

WH-4-023

Product Name
WH-4-023
CAS No.
837422-57-8
Chemical Name
WH-4-023
Synonyms
KIN112;CS-1827;WH-4-023;WH-4-024;KIN001-112;WH-4-023, >=98%;)(2-((4-(4-methyL;WH-4-023 USP/EP/BP;WH-4-023, 837422-57-8;)amino)pyrimidin-4-yL
CBNumber
CB32710784
Molecular Formula
C32H36N6O4
Formula Weight
568.67
MOL File
837422-57-8.mol
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WH-4-023 Property

Boiling point:
743.2±70.0 °C(Predicted)
Density 
1.247±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (60 mg/ml)
form 
powder
pka
7.89±0.42(Predicted)
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
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Safety

RIDADR 
UN 2811 6.1 / PGIII
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1334
Product name
WH-4-023
Purity
≥98% (HPLC)
Packaging
5mg
Price
$146
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1334
Product name
WH-4-023
Purity
≥98% (HPLC)
Packaging
25mg
Price
$564
Updated
2023/01/07
Cayman Chemical
Product number
9002067
Product name
WH-4-023
Purity
≥98%
Packaging
1mg
Price
$39
Updated
2024/03/01
Cayman Chemical
Product number
9002067
Product name
WH-4-023
Purity
≥98%
Packaging
5mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
9002067
Product name
WH-4-023
Purity
≥98%
Packaging
10mg
Price
$172
Updated
2024/03/01
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WH-4-023 Chemical Properties,Usage,Production

Description

WH-4-23 (837422-57-8) is a potent and selective inhibitor of Src family kinases Lck and Src, IC50=2 and 6 nM respectively.1,2 Also inhibits SIK, IC50=10, 22 and 60 nM for SIK 1, 2 and 3 respectively.3 May be used along with PD-325901 and CHIR-99021 to support self-renewal of na?ve human embryonic stem cells.4

Uses

WH-4-023 is a potent and selective dual lymphocyte-specific kinase (Lck) inhibitor.

Definition

ChEBI: N-(2,4-dimethoxyphenyl)-N-[2-[4-(4-methyl-1-piperazinyl)anilino]-4-pyrimidinyl]carbamic acid (2,6-dimethylphenyl) ester is a member of piperazines.

Biochem/physiol Actions

WH-4-023 (KIN112) is a potent and selective inihbitor of the tyrosine kinases Lck and Src with IC50 values of 2 nM for Lck and 6 nM for Src. WH-4-023 is a somewhat less potent inhibitor of salt-inducible kinases (SIKs) with IC50 values of 10, 22 and 60 nM for SIK 1, 2 and 3 respectively. WH-4-023 was found to support self-renewal of naive human embryonic stem cells, in particular in combination with PD 0325901 (PZ0162), CHIR99021 (SML1046), and SB-590885 (SML0501).

storage

Store at -20°C

References

Martin et al. (2006), Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity; J. Med. Chem., 49 4981 Moroco et al. (2015), A discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region; Chem. Biol. Drug. Des., 86 144 Clark et al. (2012), Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages; Proc. Natl. Acad. Sci. USA, 109 16986 Theunissen et al. (2014), Systemic identification of culture conditions for introduction and maintenance of na?ve human pluripotency; Cell Stem Cell, 15 471

WH-4-023 Preparation Products And Raw materials

Raw materials

Preparation Products

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WH-4-023 Suppliers

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View Lastest Price from WH-4-023 manufacturers

Career Henan Chemical Co
Product
2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE 837422-57-8
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
96%
Supply Ability
10kg
Release date
2019-09-04

837422-57-8, WH-4-023Related Search:

GW441756 ZM 306416 hydrochloride 2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- JX401 JAK3 INHIBITOR II JAK3 INHIBITOR I 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE 4-AMINO-3-CYANO-1,2,5,6-TETRAHYDROPYRIDINE 7-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Y27632 (hydrochloride) Saracatinib SB590885 PD 0325901 IM-12 Olaparib

  • WH-4-023
  • 2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE
  • Carbamic acid, N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-, 2,6-dimethylphenyl ester
  • KIN001-112
  • KIN112
  • 2,6-dimethylphenyl (2,4-dimethoxyphenyl)(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)carbamate WH-4-023
  • WH-4-023 2,6-DIMETHYLPHENYL 2,4-DIMETHOXYPHENYL(2-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)PYRIMIDIN-4-YL)CARBAMATE
  • WH-4-023, >=98%
  • WH-4-023, 837422-57-8
  • 2,6-Dimethylphenyl (2,4-dimethoxyphenyl)(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-
  • 2,6-Dimethylphenyl N-[2,4-bis(methyloxy)phenyl][2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate
  • DUAL LCK/SRC INHIBITOR
  • CS-1827
  • WH-4-024
  • 2,6-Dimethylphenyl-N-(2,4-dimethoxyphenyl)-N-[2-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]carbamate
  • DUAL LCK/SRC INHIBITOR;KIN001-112; KIN112
  • )(2-((4-(4-methyL
  • )amino)pyrimidin-4-yL
  • 2,6-dimethylphenyl N-(2,4-dimethoxyphenyl)-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)carbamate
  • WH-4-023 USP/EP/BP
  • 837422-57-8
  • Inhibitors
  • API