ChemicalBook > CAS DataBase List > ML277

ML277

Product Name
ML277
CAS No.
1401242-74-7
Chemical Name
ML277
Synonyms
ML277;CID-53347902;ML277;ML 277; ML-277;ML277, 10 mM in DMSO;ML-277|||CID-53347902;VU0458298-2, VU0458298-3;ML-277;ML 277;CID-53347902;CID53347902;CID 53347902;(R)-N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide;(2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide;N-[4-(4-methoxy-phenyl)-thiazol-2-]-1-[1-(4-Methylbenzenesulfonyl) pip- eridine -2-] formamide
CBNumber
CB32715653
Molecular Formula
C23H25N3O4S2
Formula Weight
471.59
MOL File
1401242-74-7.mol
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ML277 Property

Density 
1.341±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: 5 mg/ml
form 
powder
pka
8.37±0.70(Predicted)
color 
white to beige
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0524
Product name
ML277
Purity
≥98% (HPLC)
Packaging
5MG
Price
$129
Updated
2023/06/20
Sigma-Aldrich
Product number
SML0524
Product name
ML277
Purity
≥98% (HPLC)
Packaging
25MG
Price
$510
Updated
2023/06/20
Cayman Chemical
Product number
15193
Product name
ML-277
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
15193
Product name
ML-277
Purity
≥95%
Packaging
5mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
15193
Product name
ML-277
Purity
≥95%
Packaging
10mg
Price
$172
Updated
2024/03/01
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ML277 Chemical Properties,Usage,Production

Description

Potassium (K+) channels are categorized by their mode of activation and the number of transmembrane segments. The voltage-gated six-transmembrane K+ channels include KCNQ1, first recognized for its role in cardiac function and subsequently in hearing, gastrointestinal chloride secretion, and other processes. ML-277 is a potent activator of KCNQ1 channels (EC50 = 260 nM). The EC50 value of this compound at the related channels KCNQ2, KCNQ4, and hERG exceeds 30 μM. ML-277 potentiates both homomultimeric KCNQ1 channels and unsaturated heteromultimeric (KCNQ1/KCNE1) channels in model cardiomyocytes and augments delayed rectifier K+ current in cultured human cardiomyocytes.

Uses

ML277 has been used as the KCNQ1 activator to treat?cells in lung metastasis?assay.

Biochem/physiol Actions

ML277 is a potent activator of KCNQ1 (Kv7.1) channels with >100-fold selectivity versus KCNQ2 and KCNQ4 and no activity against the hERG potassium channel up to 30 μM. KCNQ1 is a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. Mutations in the KCNQ1 gene are associated with long QT syndrome (LQTS), a disorder in which the heart muscles take longer than normal to recover after each heart beat and can lead to dangerous arrhythmias such as atrial fibrillation. Activators of KCNQ1 channels could have potential use in treatments of LQTS. ML277 is the first selective and potent activator found, with an EC50 of 260 nM.

storage

Store at -20°C

ML277 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML277 Suppliers

China 103 India 1 United Kingdom 1 United States 12 Global 117
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32159
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38630
Advantage
58
United States Biological
Tel
--
Fax
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Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
ApexBio Technology
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Fax
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Email
sales@apexbt.com
Country
United States
ProdList
6251
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58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
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65
Cayman Chemical Company
Tel
--
Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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United States Biological
Tel
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Email
chemicals@usbio.net
Country
United States
ProdList
6214
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MedChemExpress
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sales@medchemexpress.com
Country
United States
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6398
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Riedel-de Haen AG
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United States
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6773
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View Lastest Price from ML277 manufacturers

Career Henan Chemical Co
Product
(2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-[(4-methylphenyl) sulfonyl]-2-piperidinecarboxamide 1401242-74-7
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-01

1401242-74-7, ML277Related Search:

VU0456810 ML 141 ML355 M348 ml390 (2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML364 ML365 ML385 ML216 ML264 PTP1B-IN-2 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML213 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML418 ML188

  • VU0458298-2, VU0458298-3
  • ML277
  • (2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide
  • (R)-N-(4-(4-Methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide
  • CID-53347902
  • ML277;ML 277; ML-277
  • (2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-[(4-methylphenyl) sulfonyl]-2-piperidinecarboxamide
  • (2R)-N-[4-(4-Methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide
  • ML-277;ML 277;CID-53347902;CID53347902;CID 53347902
  • 2-Piperidinecarboxamide, N-[4-(4-methoxyphenyl)-2-thiazolyl]-1-[(4-methylphenyl)sulfonyl]-, (2R)-
  • N-[4-(4-methoxy-phenyl)-thiazol-2-]-1-[1-(4-Methylbenzenesulfonyl) pip- eridine -2-] formamide
  • ML-277|||CID-53347902
  • ML277, 10 mM in DMSO
  • 1401242-74-7
  • API