ChemicalBook > CAS DataBase List > 5-Iodo-1H-indazole

5-Iodo-1H-indazole

Product Name: 5-Iodo-1H-indazole
CAS No.: 55919-82-9
Chemical Name: 5-Iodo-1H-indazole
Synonyms: 5-IODOINDAZOLE;5-IODO (1H)INDAZOLE;1H-Indazole, 5-iodo-;5-IODO (1H)INDAZOLE Cas: 55919-82-9
CBNumber: CB3287486
Molecular Formula: C7H5IN2
Formula Weight: 244.03
MOL File: 55919-82-9.mol

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5-Iodo-1H-indazole Property

Melting point:: 156 °C
Boiling point:: 358.2±15.0 °C(Predicted)
Density: 2.082±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
form: Crystalline Powder
pka: 12.87±0.40(Predicted)
color: Yellow to brown to purple
InChI: InChI=1S/C7H5IN2/c8-6-1-2-7-5(3-6)4-9-10-7/h1-4H,(H,9,10)
InChIKey: CGCHCLICSHIAAM-UHFFFAOYSA-N
SMILES: N1C2=C(C=C(I)C=C2)C=N1

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Safety

HS Code: 29339980

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: I707373
Product name: 5-Iodo-1H-indazole
Packaging: 500mg
Price: $75
Updated: 2021/12/16

TRC

Product number: I707373
Product name: 5-Iodo-1H-indazole
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: I707373
Product name: 5-Iodo-1H-indazole
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: J99131
Product name: 5-Iodo-1H-indazole
Packaging: 10g
Price: $70
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-H-Y6
Product name: 5-Iodo-1H-indazole
Purity: 98%
Packaging: 5G
Price: $44
Updated: 2021/12/16

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5-Iodo-1H-indazole Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

Used as a reactant for the preparation of indazole-pyridine based protein kinase B/Akt inhibitors.

Synthesis

19335-11-6

55919-82-9

General procedure for the synthesis of 5-iodo-1H-indazole from 5-aminoindazole: 1. a solution of sodium nitrite (2.7 g, 39.1 mmol) in water (40 ml) was slowly added dropwise to a solution of 1-H-indazol-5-amine (5.2 g, 39.1 mmol) in 6 at 0 °C. 2. N hydrochloric acid (73.7 ml) was added to the above mixture at 0°C. 3. the resulting mixture was added slowly and dropwise to a solution of potassium iodide (26.9 g, 162 mmol) in water (60 ml) at 0 °C. 4. The reaction mixture was stirred at room temperature for 3 hours. 5. After completion of the reaction, the reaction mixture was extracted with ethyl acetate (4 x 30 ml). 6. The organic phases were combined and washed sequentially with 10% w/v sodium thiosulfate solution (4 x 30 ml) and brine (2 x 30 ml). 7. The organic phase was dried with anhydrous magnesium sulfate and then concentrated to give a brown solid product. 8. Yield: 8.64 g (90% of theoretical). 9. 9. The structure of the product was confirmed by 3C-NMR (101 MHz, CDCl3, δppm): 84.4, 111.7, 125.6, 129.9, 133.4, 135.4, 139.0.

References

[1] Patent: WO2008/71451, 2008, A1. Location in patent: Page/Page column 47
[2] Patent: WO2014/170020, 2014, A1. Location in patent: Page/Page column 50
[3] Patent: US2009/156590, 2009, A1. Location in patent: Page/Page column 67; 69; 70
[4] Patent: US2012/28984, 2012, A1. Location in patent: Page/Page column 3
[5] Patent: WO2014/202580, 2014, A1. Location in patent: Page/Page column 164

5-Iodo-1H-indazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-Iodo-1H-indazole manufacturers

Career Henan Chemical Co

Product: 5-Iodo-1H-indazole 55919-82-9
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-04

55919-82-9, 5-Iodo-1H-indazoleRelated Search:

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5-IODO (1H)INDAZOLE Cas: 55919-82-9

55919-82-9

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