5-Iodo-1H-indazole
- Product Name
- 5-Iodo-1H-indazole
- CAS No.
- 55919-82-9
- Chemical Name
- 5-Iodo-1H-indazole
- Synonyms
- 5-IODOINDAZOLE;5-IODO (1H)INDAZOLE;1H-Indazole, 5-iodo-;5-IODO (1H)INDAZOLE Cas: 55919-82-9
- CBNumber
- CB3287486
- Molecular Formula
- C7H5IN2
- Formula Weight
- 244.03
- MOL File
- 55919-82-9.mol
5-Iodo-1H-indazole Property
- Melting point:
- 156 °C
- Boiling point:
- 358.2±15.0 °C(Predicted)
- Density
- 2.082±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- Crystalline Powder
- pka
- 12.87±0.40(Predicted)
- color
- Yellow to brown to purple
- InChI
- InChI=1S/C7H5IN2/c8-6-1-2-7-5(3-6)4-9-10-7/h1-4H,(H,9,10)
- InChIKey
- CGCHCLICSHIAAM-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(I)C=C2)C=N1
Safety
- HS Code
- 29339980
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- I707373
- Product name
- 5-Iodo-1H-indazole
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- I707373
- Product name
- 5-Iodo-1H-indazole
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- I707373
- Product name
- 5-Iodo-1H-indazole
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- OR2756
- Product name
- 5-Iodo-1H-indazole
- Purity
- 98%
- Packaging
- 1g
- Price
- $19
- Updated
- 2021/12/16
- Product number
- 3H32-H-Y6
- Product name
- 5-Iodo-1H-indazole
- Purity
- 98%
- Packaging
- 1g
- Price
- $21
- Updated
- 2021/12/16
5-Iodo-1H-indazole Chemical Properties,Usage,Production
Chemical Properties
Solid
Uses
Used as a reactant for the preparation of indazole-pyridine based protein kinase B/Akt inhibitors.
Synthesis
19335-11-6
55919-82-9
General procedure for the synthesis of 5-iodo-1H-indazole from 5-aminoindazole: 1. a solution of sodium nitrite (2.7 g, 39.1 mmol) in water (40 ml) was slowly added dropwise to a solution of 1-H-indazol-5-amine (5.2 g, 39.1 mmol) in 6 at 0 °C. 2. N hydrochloric acid (73.7 ml) was added to the above mixture at 0°C. 3. the resulting mixture was added slowly and dropwise to a solution of potassium iodide (26.9 g, 162 mmol) in water (60 ml) at 0 °C. 4. The reaction mixture was stirred at room temperature for 3 hours. 5. After completion of the reaction, the reaction mixture was extracted with ethyl acetate (4 x 30 ml). 6. The organic phases were combined and washed sequentially with 10% w/v sodium thiosulfate solution (4 x 30 ml) and brine (2 x 30 ml). 7. The organic phase was dried with anhydrous magnesium sulfate and then concentrated to give a brown solid product. 8. Yield: 8.64 g (90% of theoretical). 9. 9. The structure of the product was confirmed by 3C-NMR (101 MHz, CDCl3, δppm): 84.4, 111.7, 125.6, 129.9, 133.4, 135.4, 139.0.
References
[1] Patent: WO2008/71451, 2008, A1. Location in patent: Page/Page column 47
[2] Patent: WO2014/170020, 2014, A1. Location in patent: Page/Page column 50
[3] Patent: US2009/156590, 2009, A1. Location in patent: Page/Page column 67; 69; 70
[4] Patent: US2012/28984, 2012, A1. Location in patent: Page/Page column 3
[5] Patent: WO2014/202580, 2014, A1. Location in patent: Page/Page column 164
5-Iodo-1H-indazole Preparation Products And Raw materials
Raw materials
Preparation Products
5-Iodo-1H-indazole Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 5-Iodo-1H-indazole manufacturers
- Product
- 5-Iodo-1H-indazole 55919-82-9
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-04