EC 4.2.1.1
- Product Name
- EC 4.2.1.1
- CAS No.
- 9001-03-0
- Chemical Name
- EC 4.2.1.1
- Synonyms
- TDX-02;EC 4.2.1.1;Dehydratase;IUB: 4.2.1.1;CA, HUMAN LIVER;PANCREAS, BOVINE;CARBONIC ANHYDRASE;CARBONIC ANHYDRASE I;CARBONATE DEHYDRATASE;CARBONATE HYDRO-LYASE
- CBNumber
- CB3317318
- Molecular Formula
- NULL
- Formula Weight
- 0
- MOL File
- Mol file
EC 4.2.1.1 Property
- RTECS
- MT6446000
- storage temp.
- -20°C
- solubility
- deionized water: soluble, clear to slightly hazy, colorless (Dissolve vial contents in 0.25mL of deionised water.)
- form
- powder
- color
- white
- Water Solubility
- Soluble in water
- Merck
- 13,1822
- Concentration
- 0.01 mCi/ml
- Specific Activity
- 3-30 μCi/mg
- Solvent
- 0.01M NaH2PO4 (pH 7.2)
Safety
- Hazard Codes
- B,Xi,T
- Risk Statements
- 36-41-40-37/38-24-20/22
- Safety Statements
- 26-45-36/37/39-53
- WGK Germany
- 3
- F
- 10-21
- HS Code
- 35079090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P284Wear respiratory protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- C7025
- Product name
- Carbonic Anhydrase from bovine erythrocytes
- Purity
- BioReagent, suitable for GFC marker
- Packaging
- 1vial
- Price
- $104
- Updated
- 2024/03/01
- Product number
- C6653
- Product name
- Carbonic Anhydrase I from human erythrocytes
- Purity
- Isoelectric focusing marker, pI?6.6
- Packaging
- 1vial
- Price
- $139
- Updated
- 2024/03/01
- Product number
- C5024
- Product name
- Carbonic Anhydrase from bovine erythrocytes
- Purity
- non-denaturing PAGE marker
- Packaging
- 1vial
- Price
- $30.52
- Updated
- 2024/03/01
- Product number
- C3666
- Product name
- Carbonic Anhydrase Isozyme II from bovine erythrocytes
- Purity
- Isoelectric focusing marker, pI?5.4
- Packaging
- 1vial
- Price
- $155
- Updated
- 2024/03/01
- Product number
- C2522
- Product name
- Carbonic Anhydrase Isozyme II from bovine erythrocytes
- Purity
- lyophilized powder, ≥3,000 W-A units/mg protein
- Packaging
- 5mg
- Price
- $175
- Updated
- 2024/03/01
EC 4.2.1.1 Chemical Properties,Usage,Production
Uses
Carbonic anhydrase from human erythrocytes (HCA) has been used to study the molten-globule state of carbonic anhydrase (CA). Chaperone-like α-crystallin binds to this state of the enzyme and prevents its aggregation. The enzyme from sigma has been used for the analysis of thermodynamic stability of the enzyme. Furthermore, its clinical significance has been evaluated in human non-small cell lung cancer.
Uses
Gel filtration molecular weight marker
Uses
Carbonic anhydrase, from bovine erythrocytes, is used to create carbon dioxide capture systems and to research various purification techniques . Carbonic anhydrase is also used to study acid-base regulation in fish and carbonic anhydrase type II deficiency syndrome .
General Description
Carbonic Anhydrase is a metalloenzyme?with zinc. The active site of carbonic anhydrase contains three conserved histidine residues (His94, His96 and His119).
Biochem/physiol Actions
Carbonic anhydrase is essential for the reversible hydration of carbon dioxide. It is also crucial for the physiological processes including respiration, ion transport, acid–base balance, lipid and carbohydrate metabolic pathways. Carbonic anhydrase participates in electrolyte secretion and in the carbon dioxide fixation.
Purification Methods
Purify carbonic anhydrase by hydroxylapatite and DEAE-cellulose chromatography [Tiselius et al. Arch Biochem Biophys 65 132 1956, Biochim Biophys Acta 39 218 1960], and is then dialysed for crystallisation. A 0.5 to 1% solution of the enzyme in 0.05 M Tris-HCl pH 8.5 is dialysed against 1.75M solution of (NH4)2SO4 in the same buffer, and this solution is slowly increased in salt concentration by periodic removal of small amounts of dialysate and replacing with an equal volume of 3.5M (NH4)2SO4. The final salt concentration, in which the DEAE-cellulose fractions give beautiful birefringent suspensions of crystals, ranged from 2.4 to 2.7M and appeared first as fine crystals, then underwent transition to thin fragile plates. Carbonic anhydrase is a Zn enzyme which exists as several isoenzymes of varying degrees of activity [J Biol Chem 243 6474 1968, crystal structure: Nature, New Biology 235 131 1972; see also P.D. Boyer Ed. The Enzymes Academic Press NY, pp 587-665 1971].
EC 4.2.1.1 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from EC 4.2.1.1 manufacturers
- Product
- Carbonic Anhydrase, Lyophilized Powder 9001-03-0
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98.0%
- Supply Ability
- 1kg/month
- Release date
- 2021-08-24
- Product
- Dehydratase 9001-03-0
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99% HPLC
- Supply Ability
- 100kg
- Release date
- 2023-06-30