4-(Trifluoromethoxy)aniline

Product Name: 4-(Trifluoromethoxy)aniline
CAS No.: 461-82-5
Chemical Name: 4-(Trifluoromethoxy)aniline
Synonyms: Riluzole Related CoMpound A;AKOS B016000;4-(TrifluoroMe;Riluzole USP RC A;TIMTEC-BB SBB001667;Riluzole Impurity 10;Trifluoromethoxyaniline;4-Trifluoroethoxyaniline;4-trifluoromethoxyaniune;4-(Trifluormethoxy)anilin
CBNumber: CB3322028
Molecular Formula: C7H6F3NO
Formula Weight: 177.12
MOL File: 461-82-5.mol

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4-(Trifluoromethoxy)aniline Property

Boiling point:: 73-75 °C10 mm Hg(lit.)
Density: 1.32 g/mL at 20 °C(lit.)
refractive index: n20/D 1.463(lit.)
Flash point:: 177 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka: 3.75±0.10(Predicted)
form: Liquid
color: Clear colorless to yellow
Specific Gravity: 1.310
BRN: 2090209
Stability:: Hygroscopic
InChI: InChI=1S/C7H6F3NO/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4H,11H2
InChIKey: XUJFOSLZQITUOI-UHFFFAOYSA-N
SMILES: C1(N)=CC=C(OC(F)(F)F)C=C1
CAS DataBase Reference: 461-82-5(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi,Xn
Risk Statements: 24/25-33-38-41-36/37/38-20/21/22
Safety Statements: 26-36/37/39-45-36
RIDADR: UN 2941 6.1/PG 3
WGK Germany: 2
Hazard Note: Toxic
HazardClass: IRRITANT, TOXIC
HazardClass: 6.1
PackingGroup: III
HS Code: 29222900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H310Fatal in contact with skin

H315Causes skin irritation

H318Causes serious eye damage

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 337056
Product name: 4-(Trifluoromethoxy)aniline
Purity: 98%
Packaging: 5g
Price: $48.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR3132
Product name: Riluzole Related Compound A
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 50MG
Price: $549
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1604348
Product name: Riluzole Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1200
Updated: 2025/07/31

TCI Chemical

Product number: T1345
Product name: 4-(Trifluoromethoxy)aniline
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: T1345
Product name: 4-(Trifluoromethoxy)aniline
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $55
Updated: 2025/07/31

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4-(Trifluoromethoxy)aniline Chemical Properties,Usage,Production

Chemical Properties

CLEAR YELLOW LIQUID

Uses

4-(Trifluoromethoxy)aniline was used in the synthesis of:

side-group liquid-crystalline polymethacrylates with fluorine-containing mesogens
derivatives of 3-(quinolin-3-yl)acrylates
series of novel Shiff bases, via condensation with pyridinecarboxaldehydes in the presence of molecular sieves

Uses

4-(Trifluoromethoxy)aniline is used in the synthesis of anticancer agents and antitumor medicaments. Also, its an intermediate in the production of labelled Riluzole, a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.

Synthesis

407-14-7

461-82-5

General procedure: To a flame-dried 25 mL round-bottom flask were added activated magnesium chips (7.5 mmol, 1.5 eq.) and 5 mL of anhydrous tetrahydrofuran (THF). Two drops of 1,2-dibromoethane were added to the suspension to initiate the reaction. 5 min later, a solution of p-bromotrifluoromethoxybenzene (5 mmol, 1.0 eq.) dissolved in 5 mL of anhydrous THF was slowly added to the magnesium suspension at room temperature. A mild exothermic phenomenon was observed during the reaction. After determining the concentration of Grignard's reagent by titration, 1 mmol of the reagent was transferred to another flame-dried reaction flask. The solution was diluted with 3 mL of anhydrous toluene and after cooling to the preset temperature T, a solution of oxazepane (1.2 mmol, 1.2 equiv) dissolved in 1 mL of anhydrous toluene was added. The reaction mixture was held at temperature T for a reaction time t, followed by quenching the reaction with saturated aqueous ammonium chloride (NH4Cl). (Specific reaction temperatures and reaction times need to be listed according to the actual conditions of each substrate.)

References

[1] Organic Letters, 2013, vol. 15, # 14, p. 3734 - 3737
[2] Nature Chemistry, 2017, vol. 9, # 7, p. 681 - 688
[3] Patent: US2018/57444, 2018, A1. Location in patent: Paragraph 0098; 0134; 0135; 0171

4-(Trifluoromethoxy)aniline Preparation Products And Raw materials

Raw materials

4-(TRIFLUOROMETHOXY)BENZAMIDE 4-(Trifluoromethoxy)nitrobenzene Potassium hydroxide

Preparation Products

Triflumuron Riluzole 5-[4-(TRIFLUOROMETHOXY)PHENYL]-2-FURALDEHYDE

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View Lastest Price from 4-(Trifluoromethoxy)aniline manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-(Trifluoromethoxy)aniline 461-82-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-08

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-(Trifluoromethoxy)aniline 461-82-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

Henan Aochuang Chemical Co.,Ltd.

Product: 4-(Trifluoromethoxy)aniline 461-82-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-08

461-82-5, 4-(Trifluoromethoxy)anilineRelated Search:

4-Methoxyphenylacetone 4'-(Trifluoromethoxy)acetophenone o-Anisaldehyde Anisole (Trifluoromethoxy)benzene 3-Methoxybenzaldehyde 4-(Trifluoromethoxy)chlorobenzene 2-(Trifluoromethoxy)aniline 4-Aminobenzotrifluoride (3-Methoxyphenyl)acetonitrile 4-Methoxyphenylacetic acid 4-Methoxybenzylchloride p-Trifluoromethoxy phenol 3-(Trifluoromethoxy)aniline Trimethyl phosphite 2-Fluoroaniline Aniline 4-Fluoroaniline

Riluzole Related Compound A (25 mg) (4-trifluoromethoxyaniline)

4-(TrifluoroMethoxy)aniline, 99+% 2.5GR

Riluzole Related CoMpound A

For trifluoromethoxy aniline

4- threedifluoro Methoxyaniline

4-TrifluoroMethoxyaniline, 97+%

The trifluoro Methoxy aniline

4-(TrifluoroMe

4-(Trifluormethoxy)anilin

4-(TRIFLUOROMETHOXY)ANILINE 99.5+%

4-(trifluoromethoxy)aniline,2-(trifluoromethoxy)benzenamine

Benzenamine, 4-(trifluoromethoxy)-

4-(Trifluoromethoxy)aniline,α,α,α-Trifluoro-p-anisidine

AMino TrifluoroMethoxybenzene

4-Amino-alpha,alpha,alpha-trifluoroanisole

4-Trifluoronethoxyaniline

Riluzole USP Related Compound A

Riluzole Impurity 10

ALPHA,ALPHA,ALPHA-TRIFLUORO-P-ANISIDINE

AKOS B016000

4-(TRIFLUOROMETHOXY)ANILINE

4-TRIFLUOROMETHOXY-PHENYLAMINE

TIMTEC-BB SBB001667

4-Trifluoroethoxyaniline

4-trifluoromethoxyaniune

p-Trifluoromethoxyaniline

p-Aminotrifluoromethoxybenzene

P-Aminotrifluoromethpxybenzene

4-Aminotrifluoromethoxybenzene

4-(Trifluoromethoxy)aniline, 99+%

4-TRIFLUORO METHOXYLAMINE

α,α,α-trifluoro-p-anisidine

4-(Trifluoromethoxy)aniline 98%

4-(Trifluoromethoxy)aniline98%

4-(Trifluoromethoxy)aminobenzene

4-(trifluoromethoxy)benzenaime

Riluzole USP RC A

Trifluoromethoxyaniline

4-(Trifluomethoxy) Aniline

Riluzole Related Compound A (4-trifluoromethoxyaniline) (1604348)

2-Nitro-4-Chlorotrifluoromethoxybenzene

461-82-5

462-28-5

117528-59-4

C7H5F3NO

CF3OC6H4NH2

Organic Building Blocks

Nitrogen Compounds

ARYL HALIDE

AMINE

Building Blocks

Amines

C7

Building Blocks

C7

Chemical Synthesis

Nitrogen Compounds

Organic Building Blocks