ChemicalBook > CAS DataBase List > 4-(Trifluoromethoxy)aniline

4-(Trifluoromethoxy)aniline

Product Name
4-(Trifluoromethoxy)aniline
CAS No.
461-82-5
Chemical Name
4-(Trifluoromethoxy)aniline
Synonyms
Riluzole Related CoMpound A;AKOS B016000;4-(TrifluoroMe;Riluzole USP RC A;TIMTEC-BB SBB001667;Riluzole Impurity 10;Trifluoromethoxyaniline;4-Trifluoroethoxyaniline;4-trifluoromethoxyaniune;4-(Trifluormethoxy)anilin
CBNumber
CB3322028
Molecular Formula
C7H6F3NO
Formula Weight
177.12
MOL File
461-82-5.mol
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4-(Trifluoromethoxy)aniline Property

Boiling point:
73-75 °C10 mm Hg(lit.)
Density 
1.32 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.463(lit.)
Flash point:
177 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
pka
3.75±0.10(Predicted)
form 
Liquid
color 
Clear colorless to yellow
Specific Gravity
1.310
BRN 
2090209
Stability:
Hygroscopic
InChI
InChI=1S/C7H6F3NO/c8-7(9,10)12-6-3-1-5(11)2-4-6/h1-4H,11H2
InChIKey
XUJFOSLZQITUOI-UHFFFAOYSA-N
SMILES
C1(N)=CC=C(OC(F)(F)F)C=C1
CAS DataBase Reference
461-82-5(CAS DataBase Reference)
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Safety

Hazard Codes 
T,Xi,Xn
Risk Statements 
24/25-33-38-41-36/37/38-20/21/22
Safety Statements 
26-36/37/39-45-36
RIDADR 
UN 2941 6.1/PG 3
WGK Germany 
2
Hazard Note 
Toxic
HazardClass 
IRRITANT, TOXIC
HazardClass 
6.1
PackingGroup 
III
HS Code 
29222900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H310Fatal in contact with skin

H315Causes skin irritation

H318Causes serious eye damage

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
337056
Product name
4-(Trifluoromethoxy)aniline
Purity
98%
Packaging
5g
Price
$48.2
Updated
2025/07/31
Sigma-Aldrich
Product number
PHR3132
Product name
Riluzole Related Compound A
Purity
pharmaceutical secondary standard, certified reference material
Packaging
50MG
Price
$549
Updated
2025/07/31
Sigma-Aldrich
Product number
1604348
Product name
Riluzole Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
25mg
Price
$1200
Updated
2025/07/31
TCI Chemical
Product number
T1345
Product name
4-(Trifluoromethoxy)aniline
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$20
Updated
2025/07/31
TCI Chemical
Product number
T1345
Product name
4-(Trifluoromethoxy)aniline
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$55
Updated
2025/07/31
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4-(Trifluoromethoxy)aniline Chemical Properties,Usage,Production

Chemical Properties

CLEAR YELLOW LIQUID

Uses

4-(Trifluoromethoxy)aniline was used in the synthesis of:

  • side-group liquid-crystalline polymethacrylates with fluorine-containing mesogens
  • derivatives of 3-(quinolin-3-yl)acrylates
  • series of novel Shiff bases, via condensation with pyridinecarboxaldehydes in the presence of molecular sieves

Uses

4-(Trifluoromethoxy)aniline is used in the synthesis of anticancer agents and antitumor medicaments. Also, its an intermediate in the production of labelled Riluzole, a neuroprotective agent. Modulates glutamatergic transmission. A glutamate release inhibitor. An anticonvulsant.

Synthesis

407-14-7

461-82-5

General procedure: To a flame-dried 25 mL round-bottom flask were added activated magnesium chips (7.5 mmol, 1.5 eq.) and 5 mL of anhydrous tetrahydrofuran (THF). Two drops of 1,2-dibromoethane were added to the suspension to initiate the reaction. 5 min later, a solution of p-bromotrifluoromethoxybenzene (5 mmol, 1.0 eq.) dissolved in 5 mL of anhydrous THF was slowly added to the magnesium suspension at room temperature. A mild exothermic phenomenon was observed during the reaction. After determining the concentration of Grignard's reagent by titration, 1 mmol of the reagent was transferred to another flame-dried reaction flask. The solution was diluted with 3 mL of anhydrous toluene and after cooling to the preset temperature T, a solution of oxazepane (1.2 mmol, 1.2 equiv) dissolved in 1 mL of anhydrous toluene was added. The reaction mixture was held at temperature T for a reaction time t, followed by quenching the reaction with saturated aqueous ammonium chloride (NH4Cl). (Specific reaction temperatures and reaction times need to be listed according to the actual conditions of each substrate.)

References

[1] Organic Letters, 2013, vol. 15, # 14, p. 3734 - 3737
[2] Nature Chemistry, 2017, vol. 9, # 7, p. 681 - 688
[3] Patent: US2018/57444, 2018, A1. Location in patent: Paragraph 0098; 0134; 0135; 0171

4-(Trifluoromethoxy)aniline Preparation Products And Raw materials

Raw materials

4-(TRIFLUOROMETHOXY)BENZAMIDE 4-(Trifluoromethoxy)nitrobenzene Potassium hydroxide

Preparation Products

Triflumuron Riluzole 5-[4-(TRIFLUOROMETHOXY)PHENYL]-2-FURALDEHYDE
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View Lastest Price from 4-(Trifluoromethoxy)aniline manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-(Trifluoromethoxy)aniline 461-82-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-08
Hebei Chuanghai Biotechnology Co., Ltd
Product
4-(Trifluoromethoxy)aniline 461-82-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-30
Henan Aochuang Chemical Co.,Ltd.
Product
4-(Trifluoromethoxy)aniline 461-82-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-08

461-82-5, 4-(Trifluoromethoxy)anilineRelated Search:

4-Methoxyphenylacetone 4'-(Trifluoromethoxy)acetophenone o-Anisaldehyde Anisole (Trifluoromethoxy)benzene 3-Methoxybenzaldehyde 4-(Trifluoromethoxy)chlorobenzene 2-(Trifluoromethoxy)aniline 4-Aminobenzotrifluoride (3-Methoxyphenyl)acetonitrile 4-Methoxyphenylacetic acid 4-Methoxybenzylchloride p-Trifluoromethoxy phenol 3-(Trifluoromethoxy)aniline Trimethyl phosphite 2-Fluoroaniline Aniline 4-Fluoroaniline

  • Riluzole Related Compound A (25 mg) (4-trifluoromethoxyaniline)
  • 4-(TrifluoroMethoxy)aniline, 99+% 2.5GR
  • Riluzole Related CoMpound A
  • For trifluoromethoxy aniline
  • 4- threedifluoro Methoxyaniline
  • 4-TrifluoroMethoxyaniline, 97+%
  • The trifluoro Methoxy aniline
  • 4-(TrifluoroMe
  • 4-(Trifluormethoxy)anilin
  • 4-(TRIFLUOROMETHOXY)ANILINE 99.5+%
  • 4-(trifluoromethoxy)aniline,2-(trifluoromethoxy)benzenamine
  • Benzenamine, 4-(trifluoromethoxy)-
  • 4-(Trifluoromethoxy)aniline,α,α,α-Trifluoro-p-anisidine
  • AMino TrifluoroMethoxybenzene
  • 4-Amino-alpha,alpha,alpha-trifluoroanisole
  • 4-Trifluoronethoxyaniline
  • Riluzole USP Related Compound A
  • Riluzole Impurity 10
  • ALPHA,ALPHA,ALPHA-TRIFLUORO-P-ANISIDINE
  • AKOS B016000
  • 4-(TRIFLUOROMETHOXY)ANILINE
  • 4-TRIFLUOROMETHOXY-PHENYLAMINE
  • TIMTEC-BB SBB001667
  • 4-Trifluoroethoxyaniline
  • 4-trifluoromethoxyaniune
  • p-Trifluoromethoxyaniline
  • p-Aminotrifluoromethoxybenzene
  • P-Aminotrifluoromethpxybenzene
  • 4-Aminotrifluoromethoxybenzene
  • 4-(Trifluoromethoxy)aniline, 99+%
  • 4-TRIFLUORO METHOXYLAMINE
  • α,α,α-trifluoro-p-anisidine
  • 4-(Trifluoromethoxy)aniline 98%
  • 4-(Trifluoromethoxy)aniline98%
  • 4-(Trifluoromethoxy)aminobenzene
  • 4-(trifluoromethoxy)benzenaime
  • Riluzole USP RC A
  • Trifluoromethoxyaniline
  • 4-(Trifluomethoxy) Aniline
  • Riluzole Related Compound A (4-trifluoromethoxyaniline) (1604348)
  • 2-Nitro-4-Chlorotrifluoromethoxybenzene
  • 461-82-5
  • 462-28-5
  • 117528-59-4
  • C7H5F3NO
  • CF3OC6H4NH2
  • Organic Building Blocks
  • Nitrogen Compounds
  • ARYL HALIDE
  • AMINE
  • Building Blocks
  • Amines
  • C7
  • Building Blocks
  • C7
  • Chemical Synthesis
  • Nitrogen Compounds
  • Organic Building Blocks