Acid-PEG6-t-butyl ester

Product Name: Acid-PEG6-t-butyl ester
CAS No.: 2093153-84-3
Chemical Name: Acid-PEG6-t-butyl ester
Synonyms: COOH-PEG6-OtBu;Acid-PEG6-C2-Boc;COOH-PEG6-COOtBu;Acid-PEG6-t-Bu Ester;Acid-PEG6-t-butyl ester;HOOCCH2CH2O-PEG5-CH2CH2COOtBu;Carboxy-PEG6-tert-butyl Ester;4,7,10,13,16,19-Hexaoxadocosanedioic acid, 1-(1,1-dimethylethyl) ester;HOOCCH2CH2O-PEG5-CH2CH2COOtBu/4,7,10,13,16,19-Hexaoxadocosanedioic acid, 1-(1,1-dimethylethyl) ester
CBNumber: CB33303327
Molecular Formula: C20H38O10
Formula Weight: 438.51
MOL File: 2093153-84-3.mol

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Acid-PEG6-t-butyl ester Property

Boiling point:: 528.9±50.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
solubility: Soluble in Water, DMSO, DCM, DMF
pka: 4.28±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23511
Product name: Acid-PEG6-t-butylester
Purity: 98%
Packaging: 500mg
Price: $980
Updated: 2021/12/16

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Acid-PEG6-t-butyl ester Chemical Properties,Usage,Production

Description

Acid-PEG6-t-butyl ester is a PEG linker containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

Acid-PEG6-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Acid-PEG6-t-butyl ester Preparation Products And Raw materials

Raw materials

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View Lastest Price from Acid-PEG6-t-butyl ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: COOH-PEG6-COOtBu 2093153-84-3
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-03-23

2093153-84-3, Acid-PEG6-t-butyl esterRelated Search:

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Acid-PEG6-t-butyl ester

COOH-PEG6-COOtBu

Acid-PEG6-C2-Boc

COOH-PEG6-OtBu

HOOCCH2CH2O-PEG5-CH2CH2COOtBu

Acid-PEG6-t-Bu Ester

HOOCCH2CH2O-PEG5-CH2CH2COOtBu/4,7,10,13,16,19-Hexaoxadocosanedioic acid, 1-(1,1-dimethylethyl) ester

4,7,10,13,16,19-Hexaoxadocosanedioic acid, 1-(1,1-dimethylethyl) ester

Carboxy-PEG6-tert-butyl Ester

2093153-84-3

C20H38O10

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