Amino acids Content Analysis Chemical property Uses
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L-Valine

Amino acids Content Analysis Chemical property Uses
Product Name
L-Valine
CAS No.
72-18-4
Chemical Name
L-Valine
Synonyms
H-VAL-OH;L-Val;L-Val-OH;Valin;2-AMINO-3-METHYLBUTANOIC ACID;L-VALINE (13C5, 99%);(S)-ALPHA-AMINOISOVALERIC ACID;(s)-2-amino-3-methylbutyricacid;(S)-alpha-Aminoisovaleric acid, (L)-2-Amino-3-methylbutanoic acid;-VaL
CBNumber
CB3381690
Molecular Formula
C5H11NO2
Formula Weight
117.15
MOL File
72-18-4.mol
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L-Valine Property

Melting point:
295-300 °C (subl.) (lit.)
alpha 
28 º (c=8, 6N HCl)
Boiling point:
213.6±23.0 °C(Predicted)
Density 
1.23
refractive index 
28 ° (C=8, HCl)
storage temp. 
2-8°C
solubility 
H2O: 25 mg/mL
form 
powder
pka
2.29(at 25℃)
color 
White
PH
5.5-6.5 (100g/l, H2O, 20℃)
Odor
odorless
Odor Type
odorless
optical activity
[α]20/D +27.0±0.5°, c = 5% in 5 M HCl
Water Solubility 
85 g/L (20 ºC)
λmax
λ: 260 nm Amax: 0.15
λ: 280 nm Amax: 0.1
Merck 
14,9909
BRN 
1721136
InChIKey
KZSNJWFQEVHDMF-BYPYZUCNSA-N
LogP
0.29
CAS DataBase Reference
72-18-4(CAS DataBase Reference)
NIST Chemistry Reference
Valine(72-18-4)
EPA Substance Registry System
L-Valine (72-18-4)
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Safety

Hazard Codes 
Xn
Risk Statements 
40
Safety Statements 
24/25-36-22
WGK Germany 
3
RTECS 
YV9361000
TSCA 
Yes
HS Code 
29224995
Hazardous Substances Data
72-18-4(Hazardous Substances Data)
Toxicity
LD50 intraperitoneal in rat: 5390mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.16006
Product name
(S)-(+)-Valine
Purity
for synthesis
Packaging
25g
Price
$54.5
Updated
2024/03/01
Sigma-Aldrich
Product number
8.16006
Product name
(S)-(+)-Valine
Purity
for synthesis
Packaging
100g
Price
$86.2
Updated
2024/03/01
Sigma-Aldrich
Product number
50848
Product name
L-Valine
Purity
certified reference material, TraceCERT
Packaging
100mg
Price
$134
Updated
2024/03/01
Sigma-Aldrich
Product number
1708503
Product name
L-Valine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$519
Updated
2024/03/01
TCI Chemical
Product number
V0014
Product name
L-Valine
Purity
>98.0%(T)
Packaging
25g
Price
$30
Updated
2024/03/01
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L-Valine Chemical Properties,Usage,Production

Amino acids

L-Valine is a kind of branched-chain amino acids (BCAA). Animal cannot synthesize it by itself. It must be obtained from the diet to meet their nutritional needs. Therefore L-valine belongs to the essential amino acids.
Amino acids are the basic structural unit of protein synthesis, and the predecessor of other amines that metabolism needs. They are indispensable materials in our life. At present, it is known that there are 20 to 30 amino acids. Some of them can be synthesized in the human body, which are known as non-essential amino acids. And some, called essential amino acids, cannot be synthesized in the human body that should be supplemented from the outside. Mammal cells need twelve essential amino acids: L-arginine, L-cystine, L-histidine, L-leucine, L-isoleucine, L-lysine, L-methionine, L-phenylalanine, L-threonine, L-tryptophan, L-tyrosine, L-valine. These amino acids are all laevoisomer, and some non-essential amino acids of dextroisomer may have inhibitory effect on cultured cells.
L-amino acids can easier to be absorbed than D-amino acids. And the absorption of D, L-methionine has no difference. There is competition between the body transport of amino acids. The transporting of an amino acid can be suppressed by the presence of another amino acid. For example, L-valine and L-methionine can inhibit the absorption of L-leucine. Excessive lysine in dietary can inhibit the absorption of arginine. High concentration (100mM) of L-valine has no effect on the absorption of L-methionine. Because it can be transported through another route.

Content Analysis

About 200mg sample is accurately weighed, dissolved in 3ml formic acid and 50ml glacial acetic acid. Add 2 drops of crystal violet test solution (TS-74), then use 0.1mol/L perchloric acid to titrate the solution to green or blue disappear entirely. Each Ml0.1mol/L perchloric acid is equivalent to 11.72mg L-valine (C5H11NO2).

Chemical property

White crystal or crystalline powder, odorless, bitter taste. Soluble in water, solubility in water of 8.85% at 25℃. Almost insoluble in ethanol, ether, acetone. melting point(decomposition point) 315℃, isoelectric point 5.96, [α]25D+28.3 (C = 1-2g/ml, in 5mol/L HCl).

Uses

  • Amino acids drugs, nutritional supplements. It can be used as the main component of aminophenol transfusion and synthesize aminophenol. L-Valine is one of the three branched-chain amino acids. It is essential amino acid. It can be used to treat liver failure and central nervous system dysfunction.
  • L-Valine is essential amino acid. The requirement for men is 10mg/(kg·d). Physiological effects of the L-form is 2 times of the D-type. L-Valine deficiency can cause neurological disorders, blastocolysis, loss of weight, anemia and the like. As nutritional supplements, it can be used to prepare aminophenol transfusion and synthesize aminophenol with other essential amino acid infusion. Valine added to metric pastry (1g/kg) can make the products aroma of sesame. L-Valine used in bread can also improve the flavor.
  • L-Valine is the essential amino acid. It can be used as one of pharmaceutical composition of amino acid infusion to synthesize drugs. It also can be used as food additives.
  • Nutritional supplements. It can be used to prepare aminophenol transfusion and synthesize aminophenol with other essential amino acid infusion.Valine added to metric pastry (1g/kg) can make the products aroma of sesame. L-Valine used in bread can also improve the flavor.
  • L-Valine can be used for biochemical research, the preparation of tissue culture media. It also used as amino acids nutritional drugs in medicine.

Description

Valine (abbreviated as Val or V) is an α-amino acid with the chemical formula HO2CCH(NH2)CH(CH3)2. L-Valine is one of 20 proteinogenic amino acids. Its codons are GUU, GUC, GUA, and GUG. This essential amino acid is classified as nonpolar. Human dietary sources are any proteinaceous foods such as meats, dairy products, soy products, beans and legumes.
Along with leucine and isoleucine, valine is a branched-chain amino acid. It is named after the plant valerian. In sickle-cell disease, valine substitutes for the hydrophilic amino acid glutamic acid in hemoglobin. Because valine is hydrophobic, the hemoglobin is prone to abnormal aggregation.

Chemical Properties

White or almost white, crystalline powder or colourless crystals, soluble in water, very slightly soluble in alcohol.

Uses

L-Valine is an essential amino acid and one of 20 proteinogenic amino acids. L-Valine cannot be manufactured by the body and must be acquired through diet or supplementation. L-valine is found in grains, dairy products, mushrooms, meats, peanuts and soy proteins. L-Valine has been used in studies to attenuate arrhythmias and induce hypotensive effects.

Uses

valine is an amino acid used as a skin-conditioning and odor-masking agent. It is more commonly used in hair care preparations than in skin care.

Definition

ChEBI: The L-enantiomer of valine.

Biosynthesis

Valine is an essential amino acid, hence it must be ingested, usually as a component of proteins. It is synthesized in plants via several steps starting from pyruvic acid. The initial part of the pathway also leads to leucine. The intermediate α-ketoisovalerate undergoes reductive amination with glutamate. Enzymes involved in this biosynthesis include :
Acetolactate synthase
Acetohydroxy acid isomeroreductase
Dihydroxyacid dehydratase
Valine aminotransferase.

Synthesis Reference(s)

Tetrahedron Letters, 22, p. 2411, 1981 DOI: 10.1016/S0040-4039(01)82922-1
Chemical and Pharmaceutical Bulletin, 23, p. 167, 1975 DOI: 10.1248/cpb.23.167

General Description

Valine is an essential amino acid, involved in the biosynthesis of glutamine and alanine. Valine being a branched-chain amino acid (BCAA), maintains a balance among the BCAAs. L-Valine serves as an energy fuel.

Biochem/physiol Actions

Valine is an essential amino acid, involved in the biosynthesis of glutamine and alanine. Valine being a branched-chain amino acid (BCAA) maintains a balance among the BCAAs. L-Valine serves as an energy fuel. Long term deficiency of L-Valine leads to growth failure, organ damage and loss of muscle mass.

Side effects

L-valine is a natural substance that is necessary for our health. As such, it generally does not have any side effects. However, taking large quantities of L-valine can cause fatigue, nausea, and a lack of muscle coordination.
Extremely high doses of L-valine can be dangerous. Excessive levels of L-valine can cause your body to produce excess ammonia which is toxic.
Extremely high levels of L-valine can cause your skin to tingle and can lead to hallucinations.

Safety Profile

Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Synthesis

Racemic valine can be synthesized by bromination of isovaleric acid followed by amination of the α-bromo derivative
HO2CCH2CH(CH3)2 + Br2 → HO2CCHBrCH(CH3)2 + HBr
HO2CCHBrCH(CH3)2 + 2 NH3 → HO2CCH(NH2)CH(CH3)2 + NH4Br
.

Purification Methods

Crystallise L-valine from water by addition of EtOH. It sublimes at 178-188o/0.03mm with 99.3% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Perrin J Chm Soc 3125 1958, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2368-23771961, Beilstein 4 IV 2659.]

Nomenclature

According to IUPAC, carbon atoms forming valine are numbered sequentially starting from 1 denoting the carboxyl carbon, whereas 4 and 4' denote the two terminal methyl carbons.

L-Valine Preparation Products And Raw materials

Raw materials

DL- amino acids D(+)-Glucose Hydantoin 2-Methyl-1-propanol L-Glutamic acid Valine DL-Valine Urea HYDROGEN CYANIDE Isobutyraldehyde Ammonium carbonate Isobutyronitrile

Preparation Products

N-Boc-L-valine (S)-(+)-2-HYDROXY-3-METHYLBUTYRIC ACID
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L-Valine Suppliers

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View Lastest Price from L-Valine manufacturers

HebeiShuoshengImportandExportco.,Ltd
Product
L-Valine 72-18-4
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-06
Jinan Finer Chemical Co., Ltd
Product
L-Valine 72-18-4
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
200mt
Release date
2021-11-24
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
L-Valine 72-18-4
Price
US $25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-04-25

72-18-4, L-ValineRelated Search:

Lithium bis(trimethylsilyl)amide METHYL 4-(4-AMINOPHENYL)BUTANOATE ALTRENOGEST DL-Valine Isovaleric acid N,N-Dimethyl-1,4-phenylenediamine 4-Aminobutyric acid L-Valine methyl ester hydrochloride Glycine Folic acid Valine Tris(hydroxymethyl)aminomethane 4-(4-Aminophenyl)butyric acid Ethyl 2-(Chlorosulfonyl)acetate Benzyldimethylcarbinyl butyrate (S)-(+)-2-Amino-3-methyl-1-butanol L-Leucine L-Methionine

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