Orphenadrine citrate

Product Name: Orphenadrine citrate
CAS No.: 4682-36-4
Chemical Name: Orphenadrine citrate
Synonyms: X-Ota;Flexon;X-Otag;Banflex;Benhexal;Flexoject;Einecs 225-137-5;Orphenadrine citrate;ORPHENADRINECITRATE,USP;Orphenadrine citrate CRS
CBNumber: CB3401680
Molecular Formula: C24H31NO8
Formula Weight: 461.5
MOL File: 4682-36-4.mol

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Orphenadrine citrate Property

Melting point:: 132-1340C
storage temp.: Sealed in dry,2-8°C
solubility: Sparingly soluble in water, slightly soluble in ethanol (96 per cent).
form: Solid
color: White to Pale Beige
InChIKey: ASDBZPGDZBFZAH-UHFFFAOYSA-N
CAS DataBase Reference: 4682-36-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-40-20/21/22
Safety Statements: 22-36-62-38-36/37/39-28-26-24/25
RIDADR: 3249
WGK Germany: 3
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 2922190900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: O4630
Product name: Orphenadrine citrate salt
Purity: analytical standard
Packaging: 5g
Price: $44.82
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1479009
Product name: Orphenadrine citrate salt
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0000101
Product name: Orphenadrine citrate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0000101
Price: $153
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHR1777
Product name: Orphenadrine citrate
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 1g
Price: $179
Updated: 2024/03/01

TRC

Product number: O695300
Product name: Orphenadrine citrate salt
Packaging: 25g
Price: $495
Updated: 2021/12/16

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Orphenadrine citrate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Norflex,Riker,US,1959

Uses

skeletal muscle relaxant, antihistaminic agent

Uses

A histaminergic compound

Uses

Muscle relaxant (skeletal); antihistaminic

Definition

ChEBI: A citrate salt which comprises equimolar amounts of orphenadrine and citric acid.

Manufacturing Process

As described in US Patent 2,567,351, o-methylbenzhydryl bromide is added slowly to β-dimethylaminoethanol at refluxing temperature. After the addition has been completed the mixture is refluxed and stirred for an additional 16 hours. The mixture is cooled and the bottom layer consisting of the crude hydrobromide salt of β-dimethylaminoethanol is drawn off. The excess amino alcohol is distilled from the upper layer in vacuo and the residue is reacted with citric acid.

brand name

Norflex (3M Pharmaceuticals).

Therapeutic Function

Muscle relaxant

General Description

Orphenadrine citrate, N,Ndimethyl-2-(o-methyl-α-phenylbenzyloxy)ethylamine citrate(1:1) (Norflex), introduced in 1957, is closely related todiphenhydramine structurally but has much lower antihistaminicactivity and much higher anticholinergic action.Likewise, it lacks the sedative effects characteristic ofdiphenhydramine. Pharmacological testing indicates that itis not primarily a peripherally acting anticholinergic becauseit has only weak effects on smooth muscle, on the eye,and on secretory glands. It does reduce voluntary musclespasm, however, by a central inhibitory action on cerebralmotor areas, a central effect similar to that of atropine.

Biological Activity

Muscarinic receptor antagonist; H1 histamine receptor antagonist; muscle relaxant. Orphenadrine has also been reported to inhibit the noradrenergic transporter and to block the NMDA receptor ion channel.

Clinical Use

Orphenadrine citrate is used for the symptomatic treatment ofParkinson disease. It relieves rigidity better than it doestremor, and in certain cases, it may accentuate the latter. Thedrug combats mental sluggishness, akinesia, adynamia, andlack of mobility, but this effect seems to diminish rather rapidlywith prolonged use. It is best used as an adjunct to theother agents, such as benztropine, procyclidine, cycrimine,and trihexyphenidyl, in the treatment of paralysis agitans.Orphenadrine citrate is also used as an adjunct to rest, physiotherapy,and other measures to relieve pain of local musclespasm (e.g., nocturnal leg cramps).
The drug has a low incidence of the usual side effectsfor this group, namely, dryness of mouth, nausea, and mildexcitation.

Orphenadrine citrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Orphenadrine citrate Suppliers

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View Lastest Price from Orphenadrine citrate manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: Benoxinate Hydrochloride 4682-36-4
Price: US $19.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 ton
Release date: 2024-08-22

Shaanxi Dideu Medichem Co. Ltd

Product: Orphenadrine Citrate 4682-36-4
Price: US $1.00-22.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000KG
Release date: 2024-08-06

Hebei Zhanyao Biotechnology Co. Ltd

Product: Orphenadrine Citrate 4682-36-4
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2022-01-07

4682-36-4, Orphenadrine citrateRelated Search:

Citric acid monohydrate 2-Nitrotoluene 2-Methylbenzotrifluoride Citric acid Sildenafil citrate N,N-Dimethyl-1,4-phenylenediamine Anisole Orphenadrine Diphenhydramine 4-Methylanisole N,N-Dimethylformamide o-Xylene 4-Methoxyphenol Sodium citrate Calcium citrate Ethylbenzene Potassium Citrate 2-Nitro-4-methylsulfonyltoluene

beta-dimethylaminoethyl 2-methylbenzhydryl ether citrate

BETA-DIMETHYLAMINOETHYL 2-METHYLBENZHYDRYL ETHER CITRATE SALT

o-methyldiphenhydramine citrate

ORPHENADRINE CITRATE SALT

orphenadrine dihydrogen citrate

Banflex

N,N-Dimethyl-2-[(2-methylphenyl)phenylmethoxy]ethanamine Citrate Salt

X-Ota

β-dimethylaminoethyl 2-methylbenzhydryl ether hydrochloride

ORPHENADRINECITRATE,USP

Orphenadrine citrate

Benhexal

Einecs 225-137-5

Ethanamine, N,N-dimethyl-2-((2-methylphenyl)phenyl)methoxy)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Ethylamine, N,N-dimethyl-2-((o-methyl-alpha-phenylbenzyl)oxy)-, citrate (1:1)

Flexoject

Flexon

X-Otag

Orphenadrine Citrate (200 mg)

N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-ethanamine,2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Orphenadrine citrate CRS

(RS)-N,N-Dimethyl-2-[(2-methylphenyl)phenylmethoxy]- ethanamine dihydrogen 2-hydroxypropane-1,2,3- tricarboxylate

N,N-Dimethyl-2-(phenyl(o-tolyl)methoxy)ethanamine 2-hydroxypropane-1,2,3-tricarboxylate

Orphenadrine Citrate(Mephenamine Citrate,Norflex)

Orphenadrine citrateQ: What is Orphenadrine citrate Q: What is the CAS Number of Orphenadrine citrate Q: What is the storage condition of Orphenadrine citrate Q: What are the applications of Orphenadrine citrate

Orphenadrine Citrate (1479009)

Orphenadrine Citrate, 10 mM in DMSO

4682-36-4

C24H31NO8

C18H23NOC6H8O7

Analytical Standards

Alphabetic

Analytical Chromatography Product Catalog

Relieve pain of the local muscle spasmodic auxiliary drug use

API

APIs

Inhibitors

NORFLEX

Intermediates & Fine Chemicals

Pharmaceuticals

Amines

Aromatics