ChemicalBook > CAS DataBase List > K-252C

K-252C

Product Name
K-252C
CAS No.
85753-43-1
Chemical Name
K-252C
Synonyms
K-252C;Staurosporonine;Staurosporinone;STAUROSPORINE AGLYCONE;K-252c(Staurosporinone);Staurosporinone, K-252c;K252c, Ready Made Solution;Staurosporine Aglycone >99%;K-252c - CAS 85753-43-1 - Calbiochem;Staurosporinone, Staurosporine Aglycone
CBNumber
CB3406463
Molecular Formula
C20H13N3O
Formula Weight
311.34
MOL File
85753-43-1.mol
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K-252C Property

Melting point:
>200°C (dec.)
storage temp. 
−20°C
solubility 
DMSO: 10 mg/mL, soluble
form 
solid
color 
Pale Brown to Light Brown
Water Solubility 
Soluble in DMSO at 25mM. Also soluble in methanol. Insoluble in water.
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Safety

Safety Statements 
22-24/25
RIDADR 
NA 1993 / PGIII
WGK Germany 
3
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
420305
Product name
K-252c
Packaging
1mg
Price
$289
Updated
2024/03/01
Alfa Aesar
Product number
J63090
Product name
K252c, 99%
Packaging
5mg
Price
$465
Updated
2021/12/16
Alfa Aesar
Product number
J63090
Product name
K252c, 99%
Packaging
1mg
Price
$104
Updated
2021/12/16
Cayman Chemical
Product number
13514
Product name
K-252c
Purity
≥98%
Packaging
1mg
Price
$87
Updated
2024/03/01
Cayman Chemical
Product number
13514
Product name
K-252c
Purity
≥98%
Packaging
5mg
Price
$341
Updated
2024/03/01
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K-252C Chemical Properties,Usage,Production

Uses

Inhibits protein kinase C

Biological Activity

Inhibitor of protein kinase C (IC 50 = 2.45 μ M) that displays ~ 10-fold selectivity over protein kinase A (IC 50 = 25.7 μ M). Also inhibits β -lactamase, malate dehydrogenase and chymotrypsin (IC 50 values are 8, 8 and 10 μ M respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC 50 values range from 0.13-0.32 μ M). Shows no activity against herpes simplex virus (HSV).

storage

-20°C

References

1. fabre s, prudhomme m, rapp m. protein kinase c inhibitors; structure-activity relationships in k252c-related compounds. bioorg med chem 1993,1:193-196.2. hashimoto s. k-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in pc12h cells. j cell biol 1988,107:1531-1539.3. raychaudhuri sp, sanyal m, weltman h, kundu-raychaudhuri s. k252a, a high-affinity nerve growth factor receptor blocker, improves psoriasis: an in vivo study using the severe combined immunodeficient mouse-human skin model. j invest dermatol 2004,122:812-819.

K-252C Preparation Products And Raw materials

Raw materials

Preparation Products

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K-252C Suppliers

China 59 Germany 2 India 2 Japan 1 Switzerland 1 United Kingdom 5 United States 16 Global 86
Aurisco Pharmaceutical (Tianjin) Inc.
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85753-43-1, K-252CRelated Search:

Midostaurin Lestaurtinib KT5823 KT5720 POTASSIUM NITRATE EXTRA PURE, B. P.,FCC, E 252 C.I. Acid Red 252 NSC 252 1,3,5,7,9-Pentaoxa-252, 452,652,852-tetraplumbacyclotridec-11 -ene-10,13-dione, (Z)- PROTEIN KINASE INHIBITOR K-252A FROM NOCARDIOPSIS SP.) HC-252 Amberlite 252, Ion Exchange Resin AKOS 213-252 STAUROSPORINE SB218078 STAUROSPORINE ANTIBIOTIC UCN-02 4'-demethylamino-4'-hydroxystaurosporine GO 6976

  • K-252C
  • STAUROSPORINE AGLYCONE
  • Staurosporinone
  • 6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
  • Staurosporine Aglycone >99%
  • Staurosporinone, K-252c
  • K-252c(Staurosporinone)
  • K252c / Staurosporine Aglycone>99%/ Staurosporinone, K-252C / 6,7,12,13-Tetrahydro-5H-Indolo[2,3-A]Pyrrolo[3,4-C]Carbazol-5-One
  • K252c, Ready Made Solution
  • Staurosporonine
  • Staurosporinone, Staurosporine Aglycone
  • K-252c - CAS 85753-43-1 - Calbiochem
  • 5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one, 6,7,12,13-tetrahydro-
  • 85753-43-1
  • C20H13N3O
  • v-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Src)
  • Kinase/Phosphatase Biology
  • Non-Receptor Tyrosine Kinase Inhibitors
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Inhibitor