K-252C

Product Name: K-252C
CAS No.: 85753-43-1
Chemical Name: K-252C
Synonyms: K-252C;Staurosporonine;Staurosporinone;STAUROSPORINE AGLYCONE;K-252c(Staurosporinone);Staurosporinone, K-252c;K252c, Ready Made Solution;Staurosporine Aglycone >99%;K-252c - CAS 85753-43-1 - Calbiochem;Staurosporinone, Staurosporine Aglycone
CBNumber: CB3406463
Molecular Formula: C20H13N3O
Formula Weight: 311.34
MOL File: 85753-43-1.mol

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K-252C Property

Melting point:: >200°C (dec.)
storage temp.: −20°C
solubility: DMSO: 10 mg/mL, soluble
form: solid
color: Pale Brown to Light Brown
Water Solubility: Soluble in DMSO at 25mM. Also soluble in methanol. Insoluble in water.

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Safety

Safety Statements: 22-24/25
RIDADR: NA 1993 / PGIII
WGK Germany: 3
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 420305
Product name: K-252c
Packaging: 1mg
Price: $289
Updated: 2024/03/01

Alfa Aesar

Product number: J63090
Product name: K252c, 99%
Packaging: 1mg
Price: $104
Updated: 2021/12/16

Alfa Aesar

Product number: J63090
Product name: K252c, 99%
Packaging: 5mg
Price: $465
Updated: 2021/12/16

Cayman Chemical

Product number: 13514
Product name: K-252c
Purity: ≥98%
Packaging: 1mg
Price: $87
Updated: 2024/03/01

Cayman Chemical

Product number: 13514
Product name: K-252c
Purity: ≥98%
Packaging: 5mg
Price: $341
Updated: 2024/03/01

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K-252C Chemical Properties,Usage,Production

Uses

Inhibits protein kinase C

Biological Activity

Inhibitor of protein kinase C (IC 50 = 2.45 μ M) that displays ~ 10-fold selectivity over protein kinase A (IC 50 = 25.7 μ M). Also inhibits β -lactamase, malate dehydrogenase and chymotrypsin (IC 50 values are 8, 8 and 10 μ M respectively). Exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV) (IC 50 values range from 0.13-0.32 μ M). Shows no activity against herpes simplex virus (HSV).

storage

-20°C

References

1. fabre s, prudhomme m, rapp m. protein kinase c inhibitors; structure-activity relationships in k252c-related compounds. bioorg med chem 1993,1:193-196.2. hashimoto s. k-252a, a potent protein kinase inhibitor, blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in pc12h cells. j cell biol 1988,107:1531-1539.3. raychaudhuri sp, sanyal m, weltman h, kundu-raychaudhuri s. k252a, a high-affinity nerve growth factor receptor blocker, improves psoriasis: an in vivo study using the severe combined immunodeficient mouse-human skin model. j invest dermatol 2004,122:812-819.

K-252C Preparation Products And Raw materials

Raw materials

Preparation Products

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K-252C Suppliers

China 59 Germany 2 India 2 Japan 1 Switzerland 1 United Kingdom 5 United States 16 Global 86

Aurisco Pharmaceutical (Tianjin) Inc.

Tel: 022-59885855
Email: liuyujie@aurisco.com
Country: China
ProdList: 96
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55013243 15324716602
Email: 2853979810@qq.com
Country: China
ProdList: 10018
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15402
Advantage: 60

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

85753-43-1, K-252CRelated Search:

Midostaurin Lestaurtinib KT5823 KT5720 POTASSIUM NITRATE EXTRA PURE, B. P.,FCC, E 252 C.I. Acid Red 252 NSC 252 1,3,5,7,9-Pentaoxa-252, 452,652,852-tetraplumbacyclotridec-11 -ene-10,13-dione, (Z)- PROTEIN KINASE INHIBITOR K-252A FROM NOCARDIOPSIS SP.) HC-252 Amberlite 252, Ion Exchange Resin AKOS 213-252 STAUROSPORINE SB218078 STAUROSPORINE ANTIBIOTIC UCN-02 4'-demethylamino-4'-hydroxystaurosporine GO 6976

K-252C

STAUROSPORINE AGLYCONE

Staurosporinone

6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one

Staurosporine Aglycone >99%

Staurosporinone, K-252c

K-252c(Staurosporinone)

K252c / Staurosporine Aglycone>99%/ Staurosporinone, K-252C / 6,7,12,13-Tetrahydro-5H-Indolo[2,3-A]Pyrrolo[3,4-C]Carbazol-5-One

K252c, Ready Made Solution

Staurosporonine

Staurosporinone, Staurosporine Aglycone

K-252c - CAS 85753-43-1 - Calbiochem

5H-Indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one, 6,7,12,13-tetrahydro-

85753-43-1

C20H13N3O

v-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Src)

Kinase/Phosphatase Biology

Non-Receptor Tyrosine Kinase Inhibitors

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Inhibitor