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Tamsulosin hydrochloride

Description References
Product Name
Tamsulosin hydrochloride
CAS No.
106463-17-6
Chemical Name
Tamsulosin hydrochloride
Synonyms
TAMSULOSIN HCL;SOY ISOFLAVONE;FLOMAX;(R)-TaMsulosin;Omic;OMNIC;PRADIF;YM-617;Yutana;HARNAL
CBNumber
CB3410080
Molecular Formula
C20H29ClN2O5S
Formula Weight
444.97
MOL File
106463-17-6.mol
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Tamsulosin hydrochloride Property

Melting point:
228-230°C
alpha 
D24 -4.0° (c = 0.35 in methanol)
RTECS 
DB2430000
storage temp. 
2-8°C
solubility 
DMSO: >10mg/mL
form 
white powder
color 
White to Off-White
Merck 
14,9049
InChIKey
ZZIZZTHXZRDOFM-XFULWGLBSA-N
CAS DataBase Reference
106463-17-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
29350090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR1524
Product name
Tamsulosin hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
200mg
Price
$383
Updated
2024/03/01
Sigma-Aldrich
Product number
1643260
Product name
Tamsulosin hydrochloride
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
200mg
Price
$4200
Updated
2024/03/01
Sigma-Aldrich
Product number
BP876
Product name
Tamsulosin hydrochloride
Purity
British Pharmacopoeia (BP) Reference Standard
Packaging
100MG
Price
$259
Updated
2023/06/20
TCI Chemical
Product number
T2749
Product name
Tamsulosin Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
100mg
Price
$50
Updated
2024/03/01
TCI Chemical
Product number
T2749
Product name
Tamsulosin Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$244
Updated
2024/03/01
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Tamsulosin hydrochloride Chemical Properties,Usage,Production

Description

Tamsulosin hydrochloride is the hydrochloride form of Tamsulosin (Trade name: Alna ® / Flomax ®). It is a kind of medication used for the treatment of symptomatic benign prostatic hyperplasia (BPH), boosting the passage of kidney stones. It can also be used for the treatment of acute urinary retention. It is a kind of selective antagonist of alpha-1A and alpha-1B-adrenoceptros located in prostate, prostatic capsule, prostatic urethra, and bladder neck. The blockage of these receptors through Tamsulosin causes the relaxation of smooth muscles in the bladder neck and prostate.

References

https://www.drugbank.ca/drugs/DB00706
https://en.wikipedia.org/wiki/Tamsulosin

Description

Tamsulosin is a potent antagonist of α1-adrenergic receptors (α1-ARs; Ki = 0.229 nM in a radioligand binding assay). It is 3,800-fold selective for α1-ARs over α2-ARs (Ki = 871 nM). Tamsulosin antagonizes norepinephrine-induced contraction of isolated rabbit aorta (pA2 = 10.11) but has no effect on contraction stimulated by histamine, serotonin , angiotensin II , or prostaglandin F2α . In vivo, tamsulosin reverses the pressor effect of phenylephrine (Item Nos. 17205 | 18619) in pithed rats. It reversibly reduces fertility in male rats when administered at a dose of 0.15 mg/kg. Tamsulosin (1-100 μg/kg) also reduces prostatic pressure in a dose-dependent manner with minimal hypotensive effects in anesthetized dogs. Formulations containing tamsulosin have been used for the treatment of benign prostatic hyperplasia.

Chemical Properties

White to Off-White Solid

Originator

Contiflo OD,Ranbaxy Laboratories,India

Uses

Specific a1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy

Uses

Specific α1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy.

Uses

antineoplastic, alkylating agent

Uses

(R)-Tamsulosin is a specific α1-adrenoceptor antagonist. It is used in the treatment of benign prostatic hypertrophy.

Uses

An α1-adrenoceptor antagonist

Definition

ChEBI: Tamsulosin hydrochloride is a hydrochloride resulting from the reaction of equimolar amounts of tamulosin and hydrogen chloride. It has a role as an alpha-adrenergic antagonist and an antineoplastic agent. It contains a tamsulosin(1+). It is an enantiomer of an ent-tamsulosin hydrochloride.

Manufacturing Process

In 1,000 ml of acetonitrile was suspended 17 g of 5-{2-[2-(2- ethoxyphenoxy)ethylamino]-1-hydroxy-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride and while stirring the suspension, 9 g of thionyl chloride was added dropwise to the suspension at room temperature, whereby the product first dissolved and then began to crystallize gradually. After stirring the mixture for two days, the crystals formed were recovered by filtration, washed with chloroform and dried to provide 15 g of 5-{1-chloro-2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride. Melting point: 197°-200°C.
In methanol was dissolved the 5-{1-chloro-2-[2-(2- ethoxyphenoxy)ethylamino]ethyl}-2-methoxybenzenesulfonamide hydrochloride and after adding thereto 10% palladium carbon, dechlorination was performed under hydrogen stream at normal temperature and pressure. The palladium carbon was filtered away and the filtrate was concentrated under reduced pressure to provide the 2-methoxy-5-{2-[2-(2- ethoxyphenoxy)ethylamino]ethyl}benzenesulfonamide hydrochloride, which was recrystallized from 120 ml of a mixture of methanol and ethanol (1:4 by volume ratio) to provide the colorless crystals thereof. The melting point of the 5-{2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl}-2- methoxybenzenesulfonamide hydrochloride: 254°-256°C.

Therapeutic Function

Antihypertensive

General Description

Tamsulosin hydrochloride is a subtypeselective a1A and a1D adrenoceptor antagonist, which exists in two enantiomeric forms, of which the R-isomer is the pharmaceutically active component. It is used to reduce urinary obstruction and is also involved in relieving the symptoms associated with symptomatic benign prostatic hyperplasia.

Hazard

Moderately toxic by ingestion.

Biological Activity

Selective α 1A -adrenoceptor antagonist (pK i values are 9.97, 9.64 and 8.86 for α 1A , α 1B and α 1D subtypes respectively). Decreases resting maximal urethral pressure with negligable effect on mean arterial blood pressure in vivo .

Biochem/physiol Actions

Tamsulosin is an α1A/1D-adrenoceptor antagonist used as a treatment of benign prostatic hypertrophy (BPH). Its activity as an ? blocker also affects the iris, and has led to complications during cataract surgery, a condition called "floppy iris" syndrome.

storage

Desiccate at RT

Tamsulosin hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Tamsulosin hydrochloride Suppliers

Canada 1 China 334 Czech 1 Europe 2 France 2 Germany 3 India 57 Japan 2 South Korea 1 United Kingdom 13 United States 44 Global 460
Novachemistry
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View Lastest Price from Tamsulosin hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Tamsulosin hydrochloride 106463-17-6
Price
US $0.00-0.00/KG
Min. Order
10g
Purity
99%min
Supply Ability
10kg
Release date
2021-07-01
Hebei Weibang Biotechnology Co., Ltd
Product
Tamsulosin hydrochloride 106463-17-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25
Hebei Yanxi Chemical Co., Ltd.
Product
Tamsulosin hydrochloride 106463-17-6
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2023-09-13

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