ChemicalBook > CAS DataBase List > Isonipecotamide

Isonipecotamide

Product Name
Isonipecotamide
CAS No.
39546-32-2
Chemical Name
Isonipecotamide
Synonyms
PIPERIDINE-4-CARBALDEHYDE;PIPERIDINE-4-CARBOXAMIDE;ISONIPECOTAMIDE;4-PIPERIDINECARBOXAMIDE;Isonipectoamide;Isonepicotamide;Isonipecotinamide;Isonipecotamide>TIMTEC-BB SBB004237;Isonipecotamide,98%
CBNumber
CB3411759
Molecular Formula
C6H12N2O
Formula Weight
128.17
MOL File
39546-32-2.mol
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Isonipecotamide Property

Melting point:
145-148 °C(lit.)
Boiling point:
237.61°C (rough estimate)
Density 
1.0754 (rough estimate)
refractive index 
1.4880 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Sparingly), Methanol (Slightly)
form 
Crystalline Powder
pka
16.48±0.20(Predicted)
color 
White to light yellow
Water Solubility 
Soluble in water.
Sensitive 
Hygroscopic
BRN 
112554
Stability:
Hygroscopic
InChIKey
DPBWFNDFMCCGGJ-UHFFFAOYSA-N
LogP
-0.88
CAS DataBase Reference
39546-32-2(CAS DataBase Reference)
EPA Substance Registry System
4-Piperidinecarboxamide (39546-32-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-36
WGK Germany 
3
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
I17907
Product name
4-Piperidinecarboxamide
Purity
97%
Packaging
25g
Price
$46
Updated
2024/03/01
Sigma-Aldrich
Product number
I17907
Product name
4-Piperidinecarboxamide
Purity
97%
Packaging
100g
Price
$145
Updated
2024/03/01
TCI Chemical
Product number
I0255
Product name
Isonipecotamide
Purity
>98.0%(GC)
Packaging
25g
Price
$70
Updated
2024/03/01
TCI Chemical
Product number
I0255
Product name
Isonipecotamide
Purity
>98.0%(GC)
Packaging
250g
Price
$377
Updated
2024/03/01
Alfa Aesar
Product number
A13442
Product name
Isonipecotamide, 98%
Packaging
10g
Price
$20.65
Updated
2024/03/01
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Isonipecotamide Chemical Properties,Usage,Production

Chemical Properties

WHITE TO LIGHT YELLOW CRYSTALLINE POWDER

Uses

Reactant for synthesis of:• ;Survival motor neuron (SMN) protein modulators1• ;Diaminotriazine hNav1.7 inhibitors2• ;Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase3• ;Orally available naphthyridine protein kinase D inhibitors4• ;Phosphodiesterase 5 inhibitors5Reactant for identification of small molecular inhibitors of importin-β mediated nublear import6

Uses

Isonipecotamide is used as a reactant for the preparation of Survival motor neuron (SMN) protein modulators, orally available naphthyridine protein kinase D inhibitors and heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase. It is also used to prepare phosphodiesterase 5 inhibitors. It is also used as a reactant for identification of small molecular inhibitors of importin-beta mediated nuclear import. It is also used as a fluorenylmethyloxycarbonyl - deprotection agent in organic synthesis.

Uses

Anesthetic, analgesic, antimicrobial and cooling agent for prevention or treatment of skin irritation.

Application

Isonipecotamide is an important substrate for organic synthesis reactions and can be used to prepare a wide range of inhibitors:
(1) Dual inhibitors of thrombin and cholinesterase with therapeutic potential for Alzheimer's disease[1].
(2) 5-HT receptor inhibitors, based on Isonipecotamide synthesised piperidine carboxamide derivatives showing signs of decreasing 5-HT levels alone while increasing dopamine levels, with antidepressant drug effects[2].
(3) Reversible inhibitors of coagulation factor Xa (fXa) and thrombin (thr) (cmpds 1-3), which have the ability to impede the infection of VERO cells with SARS-CoV-2, with cmpds3 showing a significant inhibitory effect on SARS-CoV-2 infection (~30%) at lower concentrations (3-50 μM)[3].

Definition

ChEBI: 4-Piperidine carboxamide is a piperidinecarboxamide.

References

[1] ROSA PURGATORIO. First-in-Class Isonipecotamide-Based Thrombin and Cholinesterase Dual Inhibitors with Potential for Alzheimer Disease.[J]. Molecules, 2021. DOI:10.3390/molecules26175208.
[2] SHAMIM AKHTAR. Behavioral and neurochemical profile of some novel phenacyl based isonipecotamide derivatives.[J]. Pakistan journal of pharmaceutical sciences, 2012.
[3] FLAVIO DE MAIO. Evaluation of Novel Guanidino-Containing Isonipecotamide Inhibitors of Blood Coagulation Factors against SARS-CoV-2 Virus Infection.[J]. Viruses-Basel, 2022. DOI:10.3390/v14081730.

Isonipecotamide Preparation Products And Raw materials

Raw materials

Preparation Products

TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 4-Amino-1-benzylpiperidine TERT-BUTYL 4-(5-FORMYL-4-METHYL-1,3-THIAZOL-2-YL)PIPERIDINE-1-CARBOXYLATE 1-METHYL-PIPERIDINE-4-CARBONITRILE (1-Methyl-4-piperidinyl)methanamine 1-Boc-4-cyanopiperidine
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Isonipecotamide Suppliers

Americas 1 Belgium 4 Canada 3 China 262 Europe 3 France 2 Germany 6 India 29 Japan 7 Singapore 1 Slovakia 1 South Korea 1 Switzerland 3 Ukraine 1 United Kingdom 12 United States 53 Venezuela 1 Global 390
Pure Chemistry Scientific Inc.
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View Lastest Price from Isonipecotamide manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
Hexahydroisonicotinamide 39546-32-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98
Supply Ability
10000KG
Release date
2024-11-09
Hebei Yanxi Chemical Co., Ltd.
Product
Hexahydroisonicotinamide 39546-32-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
100tons
Release date
2023-09-21
Hebei Kingfiner Technology Development Co.Ltd
Product
Piperidine-4-carboxamide 39546-32-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000kg
Release date
2024-06-11

39546-32-2, IsonipecotamideRelated Search:

piperidine-N-carbaldehyde,PIPERIDINE-1-CARBALDEHYDE,N-FORMYL PIPERIDINE PIPERIDINE-1-CARBALDEHYDE 4-Benzyloxycarbonylaminopiperidine Hydrochloride DL-Pipecolinic acid Piperazine-2-carboxylic acid dihydrochloride 3-CBZ-AMINOPIPERIDINE HCL tert-Butyl 1-piperazinecarboxylate PIPERIDIN-3-ONE HYDROCHLORIDE Azido-PEG1-CH2CO2H 4-HYDROXY-3-METHYLBENZOIC ACID Benzyl 4-hydroxy-1-piperidinecarboxylate 4-Pyrimidinecarboxylic acid Isonipecotic acid 4,4-Piperidinediol hydrochloride PIPERIDINE-4-CARBOXYLIC ACID ETHYL ESTER HYDROCHLORIDE 4-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER HCL Methyl 4-piperidinecarboxylate 4-Piperidinemethanol Methyl isonipecotate

  • Piperidine-4-carboxylic acid aMide
  • IsonipecotaMide, 98% 100GR
  • Isonipecotamide, 4-Carbamoylpiperidine, 4-(Aminocarbonyl)piperidine
  • 4 - piperidine forMaMide
  • 4-Piperidinecarboxamide 97%
  • Hexahydroisonicotimide
  • HEXAHYDROISONICOTINAMIDE
  • LABOTEST-BB LT00848032
  • ISONIPECOTAMIDE
  • PIPERIDINE-4-CARBOXAMIDE
  • TIMTEC-BB SBB004237
  • 4-PIPERIDINECARBOXAMIDE
  • Isonipecotinamide
  • Isonipecotamide,98%
  • 4-Piperazine-D9-carboxamide
  • Isonipectoamide
  • PIPERIDINE-4-CARBALDEHYDE
  • Hexahydroisonicotinamide, Isonipecotamide
  • 4-Piperidinecarboxamide ,98%
  • Piperidine-4-carboxamide 98%
  • China HEXAHYDROISONICOTINAMIDE
  • Isonipecotamide&gt
  • Piperidine-4-carboxylamide
  • 4-Piperidinecarboxamide (9CI, ACI)
  • Isonipecotamide /4-Piperidinecarboxamide
  • Raffenacin impurity 42 (zopiclone impurity 7) (piperidine-4-carboxamide)
  • Piperdine-4-carboxamide
  • Piperidine-4-formamide
  • Revefenacin Impurity 40
  • Isonepicotamide
  • lsonipecotamide /4-Piperidinecarboxamide
  • 4-piperdinecarboxamide
  • 39546-32-2
  • AMINE
  • Piperidines
  • Heterocyclic Building Blocks
  • Building Blocks
  • Building Blocks
  • C5 to C7
  • Chemical Synthesis
  • Heterocyclic Building Blocks
  • Piperidines
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Amines
  • Heterocyclic Compounds
  • Piperazine
  • Pyrans, Piperidines & Piperazines