Aminoacylase

ChemicalBook > CAS DataBase List > Aminoacylase

Product Name: Aminoacylase
CAS No.: 9012-37-7
Chemical Name: Aminoacylase
Synonyms: ACYLASE;ACYLASE I;L-AMINOACYLASE;ACYLASE 1;histozyme;hippurase;acyclase I;EC 3.5.1.14;hippuricase;benzamidase
CBNumber: CB3458624
Molecular Formula: C30H34Cl2N4O
Formula Weight: 537.52316
MOL File: 9012-37-7.mol

Less

Aminoacylase Property

storage temp.: 2-8°C
form: salt-free, lyophilized powder
color: yellow-brown
EPA Substance Registry System: Aminoacylase (9012-37-7)

Less

Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-42
Safety Statements: 22-24/25-36/37-26-24
WGK Germany: 3
RTECS: BF4890000
F: 3-10-21
HS Code: 35079090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 01818
Product name: Acylase I from Aspergillus melleus
Purity: powder, brown, >0.5 U/mg
Packaging: 5g
Price: $47.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 01818
Product name: Acylase I from Aspergillus melleus
Purity: powder, brown, >0.5 U/mg
Packaging: 25g
Price: $171
Updated: 2024/03/01

Sigma-Aldrich

Product number: 01824
Product name: Acylase I, immobilized on Eupergit® C from Aspergillus sp.
Purity: ≥50?U/g moist material
Packaging: 1G
Price: $126
Updated: 2023/01/07

TCI Chemical

Product number: A0688
Product name: Acylase from Aspergillus genus
Packaging: 25g
Price: $147
Updated: 2024/03/01

Sigma-Aldrich

Product number: A8376
Product name: Acylase I from porcine kidney
Purity: Grade II, salt-free, lyophilized powder, 500-1,500units/mg protein
Packaging: 1g
Price: $230
Updated: 2024/03/01

Less

Aminoacylase Chemical Properties,Usage,Production

Description

Aminoacylase-1 (EC 3.5.1.14) is a homodimeric zinc-binding metalloenzyme. A cytosolic enzyme with a wide range of tissue expression, it cleaves acylated L-amino acids (except L-aspartate) into L-amino acids and an acyl group. L-aspartate derivatives are cleaved by aminoacylase-2 (aspartoacylase). Aminoacylase-1 is the most abundant of the aminoacylases, a class of enzymes involved in hydrolysis of N-acetylated proteins.

Uses

Acylase I from porcine kidney has been used to study the acylase I-catalyzed deacetylation of various S-alkyl-N-acetyl-L-cysteines and their carbon and oxygen analogues . Acylase I may be useful to catalyze N-acetyl amino acids to enantiomerically pure L-amino acids .

Application

Biological Functions

Aminoacylases (N-acyl-L-amino acid amidohydrolases; EC 3.5.1.14) are widely found in animals, plants and microorganisms. The primary function of these enzymes is to remove acyl residues from N-acetylated amino acids although they may also be capable of hydrolysing carboxylic acid amides to fatty acid anions and L-amino acids. Although the catalytic mechanism of aminoacylases has been known for decades, the physiological role of these enzymes is still poorly understood. Activities of a similar nature, however, have been found in certain carboxypeptidases, aminopeptidases and dipeptidases. It could be therefore suggested that aminoacylases have a role to play in protein/peptide turnover.

General Description

Acylase I belongs to the aminoacylase family of enzymes.

Biochem/physiol Actions

Acylase I catalyzes the deacetylation of N-acetyl-L-cysteine and S-alkyl-N-acetyl-L-cysteines. n-Butylmalonic acid is an inhibitor of acylase I. S-alkyl-N-acetyl-L-cysteines with short (C0-C3) and unbranched S-alkyl substituents have been found to be good acylase I substrates .

Enzyme inhibitor

Aminoacylase is a metallo-enzyme that needs Zinc (Zn2+) as a cofactor to function. The Zinc ions inside of aminoacylase are each coordinated to histidine, glutamate, aspartate, and water. The Zinc ion polarizes the water, facilitating its deprotonation by a nearby basic residue. The negatively charged hydroxide ion is nucleophilic and attacks the electrophilic carbonyl carbon of the substrate's acyl group.The exact mechanism after this point is unknown, with one possibility being that the carbonyl then reforms, breaks the amide bond, and forms the two products. At some point in the mechanism, another water molecule enters and coordinates with Zinc, returning the enzyme to its original state.
The nucleophilic attack by water is the rate-limiting step of aminoacylase's catalytic mechanism. This nucleophilic attack is reversible while the subsequent steps are fast and irreversible. This reaction sequence is an example of Michaelis–Menten kinetics, allowing one to determine KM, Kcat, Vmax, turnover number, and substrate specificity through classic Michaelis-Menten enzyme experiments. The second and third forward steps cause the formation and release of the reaction's products.

Aminoacylase Preparation Products And Raw materials

Raw materials

Ammonium sulfate

Preparation Products

D-Serine L-Aspartic acid D-Threonine L-Serine L-Threonine

Less

Aminoacylase Suppliers

Americas 1 China 101 Europe 3 Germany 5 India 4 Japan 3 Switzerland 1 United Kingdom 1 United States 20 USA 1 Global 140

Shanghai YuLue Chemical Co., Ltd.

Tel: 021-60345187 13671753212
Fax: 021-34702061
Email: lzz841106@aliyun.com
Country: China
ProdList: 10287
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006608290; 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40241
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

BeiJing Hwrk Chemicals Limted

Tel: 0757-86329057 18501085097
Fax: 010-89508210
Email: sales3.gd@hwrkchemical.com
Country: China
ProdList: 7583
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44751
Advantage: 61

BEST-REAGENT

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11726
Advantage: 57

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14443
Advantage: 57

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4647
Advantage: 58

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9725
Advantage: 55

Chengdu Forest Science and Technology Development Co., Ltd.

Tel: 028-87925786 18030648795
Fax: 028-61777050
Email: sales@cdforestchem.com
Country: China
ProdList: 1374
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9872
Advantage: 52

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22519
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25015
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9552
Advantage: 55

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8033
Advantage: 55

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9986
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41438
Advantage: 60

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15185
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15878
Advantage: 55

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12357
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai Xilong Biochemical Technology Co., Ltd.

Tel: 021-52907766-8042
Fax: 021-52906523
Country: China
ProdList: 9947
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27322
Advantage: 60

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9934
Advantage: 55

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20810
Advantage: 60

Grader reagent

Tel: 18221735425
Email: sales@xinpingchem.com
Country: China
ProdList: 9951
Advantage: 58

Shanghai Civic Chemical Technology Co., Ltd.

Tel: 021-34053660
Fax: QQ:2881074831
Email: sale2@labgogo.com
Country: China
ProdList: 2018
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Anhui kuer Bioengineering Co., Ltd

Tel: 0551-65171243 13810511747
Email: kuer@kuerhuaxue.com
Country: China
ProdList: 2997
Advantage: 55

Guangzhou Jhd Chemical Reagent Co., Ltd.

Tel: 020-84383047
Fax: 020-84380294
Email: sales@jhd.com.cn
Country: China
ProdList: 9190
Advantage: 65

9ding chemical ( Shanghai) Limited

Tel: 021-021-52271985 17721149837
Fax: +86 (21) 52271987
Email: sales@9dingchem.com
Country: China
ProdList: 19806
Advantage: 60

Jiaxing Deyi Chemical Co., Ltd.

Tel: 86-0573-85866609 13325730825
Fax: 0573-85866609
Email: 945717149@qq.com
Country: China
ProdList: 7959
Advantage: 58

Aikon International Limited

Tel: 025-66028182 18112977050
Fax: (3)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 15820
Advantage: 58

Aikon International Limited

Tel: 025-66113011 18112977050
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16028
Advantage: 58

Rhawn Reagent

Tel: 400-400-1332688 18019345275
Fax: 400-133-2688
Email: amy@rhawn.cn
Country: China
ProdList: 15503
Advantage: 58

Shanghai He Huan Chemical Co., Ltd.

Tel: 021-60345187 13917602471
Fax: 021-60345187
Email: lzz841106@aliyun.com
Country: China
ProdList: 9908
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6038 18902104717
Email: sales@heowns.com
Country: China
ProdList: 20512
Advantage: 60

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10305
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-037163312495,13303845143 13303845143
Fax: QQ3001379618
Email: 3001379618@qq.com
Country: China
ProdList: 9939
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 400-400-400-9004166 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52712
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-010-62971590 18548936886
Fax: 010-62340519
Email: 3462612863@qq.com
Country: China
ProdList: 6912
Advantage: 58

Chengdu Forest Science and Technology Development Co,. Ltd

Tel: 028-87925786 18010564218
Fax: 028-61777050
Email: vendi@cdforestchem.com
Country: China
ProdList: 1994
Advantage: 58

Hefei Bomei Biotechnology Co., Ltd.

Tel: 13739298932
Email: 531626407@qq.com
Country: China
ProdList: 2999
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4698
Advantage: 58

Henan Alfa Chemical Co., Ltd

Tel: +8618339805032
Email: alfa4@alfachem.cn
Country: China
ProdList: 12755
Advantage: 58

Shanghai UCHEM Inc.

Tel: +862156762820 +86-13564624040
Email: sales@myuchem.com
Country: China
ProdList: 6710
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: 0551-65418671
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34572
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658; 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 10002
Advantage: 58

Less

View Lastest Price from Aminoacylase manufacturers

Career Henan Chemical Co

Product: AMINOACYLASE 9012-37-7
Price: US $8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-25

9012-37-7, AminoacylaseRelated Search:

1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Ethyl isocyanoacetate SALCOMINE Cupric acetylacetonate Ferric acetylacetonate TERT-BUTYL ISOCYANIDE Tosylmethyl isocyanide METHYL ISOCYANOACETATE PHENYLSELENOL Aluminum acetylacetonate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Tris(2,4-pentanedionato)chroMiuM(III) N-BUTYLISOCYANIDE COBALT(II) ACETYLACETONATE Benzyl isocyanide 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)

PLEXAZYM(R) AC

N-ACYL-L-AMINO-ACID AMIDOHYDROLASE

N-ACYLAMINO ACID AMIDOHYDROLASE

EC 3.5.1.14

EC: 3.5.1.14

EC 3.5.1.(4)

L-AMINOACYLASE

ACYLASE, ASPERGILLUS MELLEUS

ACYLASE HOG KIDNEY

ACYLASE I

ACYLASE I, IMMOBILIZED ON EUPERGIT C

ACYLASE

ACYLASE 1

ACYLASE AMANO

AMINOACYLASE

AMINOACYLASE, ASPERGILLUS MELLEUS

AMINOACYLASE, IMMOBILIZED

hippuricase

histozyme

l-aminoacidacylase

ACYLASE FROM STREPTOMYCES HACHIJOENSIS, >30 U/G*

ACYLASE I GRADE I FROM PORCINE KIDNEY

ACYLASE I FROM ASPERGILLUS MELLEUS, >0.5 U/MG

ACYLASE FROM STREPTOMYCES CHARTREUSIS, >0.1U/MG*

ACYLASE FROM PENICILLIUM SP.*

ACYLASE I GRADE II FROM HOG KIDNEY

ACYLASE I FROM HOG KIDNEY LYOPH. SALT-FR POWDER ~15 U/MG

ACYLASE FROM STREPTOMYCES TOYOCAENSIS, ~40 U/G*

ACYLASE I FROM HOG KIDNEY, MR ~45300, 70 -110 U/MG

ACYLASE FROM STREPTOMYCES ZAOMYCETICUS, ~0.25 U/MG*

ACYLASE FROM ASPERGILLUS MELLEUS, 2-5 U/MG*

ACYLASE FROM STREPTOMYCES GRISEOCARNEUS, ~0.15 U/MG*

ACYLASE I FROM HOG KIDNEY, ~30 U/MG

AcylaseIExPigKidney(E.C.3.5.1.14)

AcylaseIfromporcinekidneylyophilizedpowder

FROM HOG KIDNEY

acylase from aspergillus melleus

acylase from streptomyces chartreusis

acylase from streptomyces hachijoensis

acylase from streptomyces toyocaensis

acylase from streptomyces zaomyceticus

acylaseifromhogkidney

alpha-n-acylaminoacidhydrolase

aminoaciddeacylase

aminoacylasei

benzamidase

dehydropeptidaseii

hippurase

acylase i from aspergillus melleus

acylase i from porcine kidney

acylase from streptomyces griseocarneus

Acylase 001

ACYLASE: FROM HOG KIDNEY

ACYLASE 1, FROM PIG KIDNEY

acyclase I

Acylase Amano, Aminoacylase

Acylase I, immobilized on Eupergit(R) C from Aspergillus sp.

Aminoacylase, immobilized, Plexazym(R) AC