Aminoacylase

ChemicalBook > CAS DataBase List > Aminoacylase

Product Name: Aminoacylase
CAS No.: 9012-37-7
Chemical Name: Aminoacylase
Synonyms: ACYLASE;ACYLASE I;L-AMINOACYLASE;ACYLASE 1;histozyme;hippurase;acyclase I;EC 3.5.1.14;hippuricase;benzamidase
CBNumber: CB3458624
Molecular Formula: C30H34Cl2N4O
Formula Weight: 537.52316
MOL File: 9012-37-7.mol

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Aminoacylase Property

storage temp.: 2-8°C
form: salt-free, lyophilized powder
color: yellow-brown
EPA Substance Registry System: Aminoacylase (9012-37-7)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-42
Safety Statements: 22-24/25-36/37-26-24
WGK Germany: 3
RTECS: BF4890000
F: 3-10-21
HS Code: 35079090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 01818
Product name: Acylase I from Aspergillus melleus
Purity: powder, brown, >0.5 U/mg
Packaging: 5g
Price: $47.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 01818
Product name: Acylase I from Aspergillus melleus
Purity: powder, brown, >0.5 U/mg
Packaging: 25g
Price: $171
Updated: 2024/03/01

Sigma-Aldrich

Product number: 01824
Product name: Acylase I, immobilized on Eupergit® C from Aspergillus sp.
Purity: ≥50?U/g moist material
Packaging: 1G
Price: $126
Updated: 2023/01/07

TCI Chemical

Product number: A0688
Product name: Acylase from Aspergillus genus
Packaging: 25g
Price: $147
Updated: 2024/03/01

Sigma-Aldrich

Product number: A3010
Product name: Acylase I from porcine kidney
Purity: Grade I, lyophilized powder, ≥2,000units/mg protein
Packaging: 100mg
Price: $126
Updated: 2024/03/01

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Aminoacylase Chemical Properties,Usage,Production

Description

Aminoacylase-1 (EC 3.5.1.14) is a homodimeric zinc-binding metalloenzyme. A cytosolic enzyme with a wide range of tissue expression, it cleaves acylated L-amino acids (except L-aspartate) into L-amino acids and an acyl group. L-aspartate derivatives are cleaved by aminoacylase-2 (aspartoacylase). Aminoacylase-1 is the most abundant of the aminoacylases, a class of enzymes involved in hydrolysis of N-acetylated proteins.

Uses

Acylase I from porcine kidney has been used to study the acylase I-catalyzed deacetylation of various S-alkyl-N-acetyl-L-cysteines and their carbon and oxygen analogues . Acylase I may be useful to catalyze N-acetyl amino acids to enantiomerically pure L-amino acids .

Application

Biological Functions

Aminoacylases (N-acyl-L-amino acid amidohydrolases; EC 3.5.1.14) are widely found in animals, plants and microorganisms. The primary function of these enzymes is to remove acyl residues from N-acetylated amino acids although they may also be capable of hydrolysing carboxylic acid amides to fatty acid anions and L-amino acids. Although the catalytic mechanism of aminoacylases has been known for decades, the physiological role of these enzymes is still poorly understood. Activities of a similar nature, however, have been found in certain carboxypeptidases, aminopeptidases and dipeptidases. It could be therefore suggested that aminoacylases have a role to play in protein/peptide turnover.

General Description

Acylase I belongs to the aminoacylase family of enzymes.

Biochem/physiol Actions

Acylase I catalyzes the deacetylation of N-acetyl-L-cysteine and S-alkyl-N-acetyl-L-cysteines. n-Butylmalonic acid is an inhibitor of acylase I. S-alkyl-N-acetyl-L-cysteines with short (C0-C3) and unbranched S-alkyl substituents have been found to be good acylase I substrates .

Enzyme inhibitor

Aminoacylase is a metallo-enzyme that needs Zinc (Zn2+) as a cofactor to function. The Zinc ions inside of aminoacylase are each coordinated to histidine, glutamate, aspartate, and water. The Zinc ion polarizes the water, facilitating its deprotonation by a nearby basic residue. The negatively charged hydroxide ion is nucleophilic and attacks the electrophilic carbonyl carbon of the substrate's acyl group.The exact mechanism after this point is unknown, with one possibility being that the carbonyl then reforms, breaks the amide bond, and forms the two products. At some point in the mechanism, another water molecule enters and coordinates with Zinc, returning the enzyme to its original state.
The nucleophilic attack by water is the rate-limiting step of aminoacylase's catalytic mechanism. This nucleophilic attack is reversible while the subsequent steps are fast and irreversible. This reaction sequence is an example of Michaelis–Menten kinetics, allowing one to determine KM, Kcat, Vmax, turnover number, and substrate specificity through classic Michaelis-Menten enzyme experiments. The second and third forward steps cause the formation and release of the reaction's products.

Aminoacylase Preparation Products And Raw materials

Raw materials

Ammonium sulfate

Preparation Products

D-Serine L-Aspartic acid D-Threonine L-Serine L-Threonine

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View Lastest Price from Aminoacylase manufacturers

Career Henan Chemical Co

Product: AMINOACYLASE 9012-37-7
Price: US $8.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10tons
Release date: 2018-12-25

9012-37-7, AminoacylaseRelated Search:

1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Ethyl isocyanoacetate SALCOMINE Cupric acetylacetonate Ferric acetylacetonate TERT-BUTYL ISOCYANIDE Tosylmethyl isocyanide METHYL ISOCYANOACETATE PHENYLSELENOL Aluminum acetylacetonate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Tris(2,4-pentanedionato)chroMiuM(III) N-BUTYLISOCYANIDE COBALT(II) ACETYLACETONATE Benzyl isocyanide 2,4-PENTANEDIONE, SILVER DERIVATIVE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)

PLEXAZYM(R) AC

N-ACYL-L-AMINO-ACID AMIDOHYDROLASE

N-ACYLAMINO ACID AMIDOHYDROLASE

EC 3.5.1.14

EC: 3.5.1.14

EC 3.5.1.(4)

L-AMINOACYLASE

ACYLASE, ASPERGILLUS MELLEUS

ACYLASE HOG KIDNEY

ACYLASE I

ACYLASE I, IMMOBILIZED ON EUPERGIT C

ACYLASE

ACYLASE 1

ACYLASE AMANO

AMINOACYLASE

AMINOACYLASE, ASPERGILLUS MELLEUS

AMINOACYLASE, IMMOBILIZED

hippuricase

histozyme

l-aminoacidacylase

ACYLASE FROM STREPTOMYCES HACHIJOENSIS, >30 U/G*

ACYLASE I GRADE I FROM PORCINE KIDNEY

ACYLASE I FROM ASPERGILLUS MELLEUS, >0.5 U/MG

ACYLASE FROM STREPTOMYCES CHARTREUSIS, >0.1U/MG*

ACYLASE FROM PENICILLIUM SP.*

ACYLASE I GRADE II FROM HOG KIDNEY

ACYLASE I FROM HOG KIDNEY LYOPH. SALT-FR POWDER ~15 U/MG

ACYLASE FROM STREPTOMYCES TOYOCAENSIS, ~40 U/G*

ACYLASE I FROM HOG KIDNEY, MR ~45300, 70 -110 U/MG

ACYLASE FROM STREPTOMYCES ZAOMYCETICUS, ~0.25 U/MG*

ACYLASE FROM ASPERGILLUS MELLEUS, 2-5 U/MG*

ACYLASE FROM STREPTOMYCES GRISEOCARNEUS, ~0.15 U/MG*

ACYLASE I FROM HOG KIDNEY, ~30 U/MG

AcylaseIExPigKidney(E.C.3.5.1.14)

AcylaseIfromporcinekidneylyophilizedpowder

FROM HOG KIDNEY

acylase from aspergillus melleus

acylase from streptomyces chartreusis

acylase from streptomyces hachijoensis

acylase from streptomyces toyocaensis

acylase from streptomyces zaomyceticus

acylaseifromhogkidney

alpha-n-acylaminoacidhydrolase

aminoaciddeacylase

aminoacylasei

benzamidase

dehydropeptidaseii

hippurase

acylase i from aspergillus melleus

acylase i from porcine kidney

acylase from streptomyces griseocarneus

Acylase 001

ACYLASE: FROM HOG KIDNEY

ACYLASE 1, FROM PIG KIDNEY

acyclase I

Acylase Amano, Aminoacylase

Acylase I, immobilized on Eupergit(R) C from Aspergillus sp.

Aminoacylase, immobilized, Plexazym(R) AC