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DIPEPTIDYLPEPTIDASE IV

Product Name
DIPEPTIDYLPEPTIDASE IV
CAS No.
54249-88-6
Chemical Name
DIPEPTIDYLPEPTIDASE IV
Synonyms
CD26;ADABP;TP103;DPP-IV;EC 3.4.14.5;CD26 (HUMAN);DPPIV (HUMAN);Glycoprotein GP110;DIPEPTIDYL PEPTIDASE;Dipeptidylpeptidase 4
CBNumber
CB3471333
Molecular Formula
NULL
Formula Weight
0
MOL File
Mol file
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DIPEPTIDYLPEPTIDASE IV Property

storage temp. 
−20°C
solubility 
0.1 M Tris-HCl, pH 8.0: soluble1 vial/mL, clear, colorless
form 
lyophilized powder
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Safety

Hazard Codes 
Xi,Xn,T
Risk Statements 
36/37/38-22-61
Safety Statements 
26-36-45-53
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P201Obtain special instructions before use.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D4943
Product name
Dipeptidyl Peptidase IV human
Purity
recombinant, expressed in baculovirus infected Sf9 cells, pkg of ≥1.0?units/vial, ≥10 units/mg protein
Packaging
1vial
Price
$700
Updated
2024/03/01
Sigma-Aldrich
Product number
D3446
Product name
Dipeptidyl Peptidase IV human
Purity
recombinant, expressed in Sf9 cells
Packaging
10μG
Price
$683
Updated
2024/03/01
Sigma-Aldrich
Product number
SAB2900184
Product name
Anti-DPP4 (AB1) antibody produced in rabbit
Purity
affinity isolated antibody, buffered aqueous solution
Packaging
50μG
Price
$674
Updated
2023/06/20
Sigma-Aldrich
Product number
SRP6056
Product name
Dipeptidylpeptidase human
Purity
recombinant, expressed in Hi-5 Insect cells, ≥95% (SDS-PAGE)
Packaging
10μG
Price
$321
Updated
2022/05/15
Usbiological
Product number
472009
Product name
DPPIV
Packaging
96Tests
Price
$731
Updated
2021/12/16
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DIPEPTIDYLPEPTIDASE IV Chemical Properties,Usage,Production

Uses

Human dipeptidyl peptidase IV has been used in a study to assess the interactive hemodynamic effects of its inhibition as well as the angiotensin-converting enzyme inhibition. Human dipeptidyl peptidase IV has also been used in a study to identify and characterize the 100 kDa High Molecular Weight Hymenoptera Venom Allergens Api m 5 and Ves v 3.

General Description

Dipeptidyl Peptidase IV (DPP4) is mapped to human chromosome 2q24.2. It comprises the N-glycosylation sites located in the β-propeller domain.

Biochem/physiol Actions

Native DPPIV is a ubiquitous type II transmembrane glycoprotein and a serine protease of the S9 prolyl-oligopeptidase family. In vivo, it is synthesized with a signal peptide, which functions as the membrane anchoring domain. There is an 88% sequence homology between the human and porcine kidney enzymes. Both exist as homodimers with a subunit molecular weight of ~30 kDa. The high mannose 100 kDa DPPIV precursor is processed in the Golgi to yield a 124 kDa heavily N-and O-linked mature glycoprotein. It is then sorted to the apical membrane through the concerted action of both N- and O-linked glycans and its association with lipid microdomains. The porcine enzyme contains 18.3% carbohydrates, which the glycan composition is 0.9% fucose, 3.4% mannose, 5.1% galactose, 8.2% glucosamine, and 0.7% sialic acid. DPPIV is highly expressed on endothelial cells, epithelial cells, and lymphocytes. It is also present in plasma in its soluble form.

Purification Methods

The aminopeptidase is purified about 2000-fold by column chromatography on CM-cellulose, hydroxylapatite and Gly-Pro AH-Sepharose. [Imai et al. J Biochem (Tokyo) 93 431 1983, Schomburg & Schomburg Springer Handbook of Enzymes 2nd Edn vol 6 p 286 2002.] DNA (deoxyribonucleic acids). The essential structures of chromosomes are DNA and contain the genetic “blueprint” in the form of separate genes. They are made up of the four deoxyribonucleic acids (nucleotides): adenylic acid, guanylic acid, cytidylic acid and thymidylic acid (designated A, G, C, T respectively) linked together by their phosphate groups in ester bonds between the 3' and 5' hydroxy groups of the 2'-deoxy-D-ribose moiety of the nucleotides. The chains form a double-stranded spiral (helix) in which the two identical nucleotide sequences run antiparallel with the heterocyclic bases hydrogen bonded (A….T, G….C) forming the “ladder” between the strands. Short sequences of DNA are available commercially, are commercially custom made or synthesised in a DNA synthesiser and purified by HPLC. Their purity can be checked by restriction enzyme cleavage followed by gel electophoresis, or directly by gel electrophoresis or analytical HPLC. Commercial DNAs are usually pure enough for direct use but can be further purified using commercially available kits involving binding to silica or other matrices and eluting with Tris buffers. There are now rapid “throughput” techniques for sequencing DNA which are very accurate.

DIPEPTIDYLPEPTIDASE IV Preparation Products And Raw materials

Raw materials

Preparation Products

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DIPEPTIDYLPEPTIDASE IV Suppliers

Alexis Corporation
Tel
--
Fax
--
Email
alexis-ch@alexis-corp.ch
Country
Switzerland
ProdList
3599
Advantage
74
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91

54249-88-6, DIPEPTIDYLPEPTIDASE IVRelated Search:


  • EC 3.4.14.5
  • DPP-IV
  • DPPIV (HUMAN)
  • DIPEPTIDYLPEPTIDASE IV
  • DIPEPTIDYLPEPTIDASE IV, ASPERGILLUS ORIZAE
  • DIPEPTIDYL PEPTIDASE FROM*PORCINE KIDNEY
  • Dipeptidylpeptidaseivfromhumanplacenta
  • dipeptidyl peptidase iv from porcine kidney
  • Dipeptidyl Peptidase IV from porcine kidney,Dipeptidyl aminopeptidase IV
  • DIPEPTIDYL PEPTIDASE IV (HUMAN)
  • DIPEPTIDYL AMINOPEPTIDASE IV
  • DIPEPTIDYL PEPTIDASE
  • CD26
  • CD26 (HUMAN)
  • Glycoprotein GP110
  • Anti-DPP4 (AB1) antibody produced in rabbit
  • Dipeptidylpeptidase 4
  • Anti-DPP4 (AB2) antibody produced in rabbit
  • ADABP
  • Adenosine deaminase complexing protein 2
  • Dipeptidylpeptidase human
  • TP103
  • Xaa-Pro dipeptidyl-peptidase
  • Dipeptidyl Peptidase IV from Human, Recombinant
  • Native Porcine Dipeptidyl Peptidase IV
  • 54249-88-6
  • Enzymes, Inhibitors, and Substrates
  • Proteolytic Enzymes and Substrates
  • Proteolytic Enzymes
  • Selective Proteolytic Enzymes
  • Biochemicals and Reagents
  • BioChemical