ChemicalBook > CAS DataBase List > 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)

1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)

Product Name
1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
CAS No.
2305369-00-8
Chemical Name
1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
Synonyms
Poma-C2-NH2·HCl;Pomalidomide-C2-NH2 HCl;Thalidomide-NH-C2-NH2.HCl;Thalidomide-4-NH-C2-NH2 HCl;Pomalidomide 4'-alkylC2-amine;Pomalidomide-C2-NH2 hydrochloride;E3 ligase Ligand 17 hydrochloride;Cereblon Ligand-Linker Conjugates 15 (hydrochloride);Pomalidomide-C2-NH2 hydrochloride;4-(2-aminoethylamino)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
CBNumber
CB35513434
Molecular Formula
C15H17ClN4O4
Formula Weight
352.78
MOL File
2305369-00-8.mol
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1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Property

storage temp. 
2-8°C
form 
Solid
color 
Light yellow to yellow
InChI
InChI=1S/C15H16N4O4.ClH/c16-6-7-17-9-3-1-2-8-12(9)15(23)19(14(8)22)10-4-5-11(20)18-13(10)21;/h1-3,10,17H,4-7,16H2,(H,18,20,21);1H
InChIKey
DSJCOXQYDMWPEY-UHFFFAOYSA-N
SMILES
O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC=CC(NCCN)=C12.Cl
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

CSNpharm
Product number
CSN23971
Product name
Pomalidomide-C2-Amine
Packaging
5mg
Price
$326
Updated
2021/12/16
DC Chemicals
Product number
DC26122
Product name
Pomalidomide-C2-NH2hydrochloride
Purity
>98%
Packaging
250mg
Price
$950
Updated
2021/12/16
DC Chemicals
Product number
DC26122
Product name
Pomalidomide-C2-NH2hydrochloride
Purity
>98%
Packaging
1g
Price
$1800
Updated
2021/12/16
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1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Chemical Properties,Usage,Production

Uses

Pomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

Biological Activity

Pomalidomide 4'-alkylC2-amine is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus an alkylC2 linker with terminal amine ready for conjugation to a target protein ligand. This product has been recently renamed. The previous name for this product was Pomalidomide - linker 7

IC 50

Cereblon

storage

Store at -20°C

References

[1] Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575. DOI:10.1021/acs.jmedchem.7b00168

1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Suppliers

China 56 United States 4 Global 60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
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58
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View Lastest Price from 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Pomalidomide-C2-NH2 hydrochloride 2305369-00-8
Price
US $0.00/g
Min. Order
1g
Purity
>96.00%
Supply Ability
1g
Release date
2024-04-01

2305369-00-8, 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)Related Search:

E3 ligase Ligand-Linker Conjugates 49 Pomalidomide-C6-PEG1-C3-PEG1-butyl iodide 6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid Pomalidomide-C6-PEG3-butyl iodide POMALIDOMIDE-C9-CO2H Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl E3 ligase Ligand-Linker Conjugates 55 Pomalidomide-6-2-2-6-N3 Pomalidomide-amido-C1-Br Pomalidomide-C6-NH2?hydrochloride Nonanoic acid, 9-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Octanoic acid, 8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- 4-[(4-Aminobutyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl β-Alanine, N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]- 4-((4-azidobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione -alkylC5-amine

  • 1H-Isoindole-1,3(2H)-dione, 4-[(2-aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1)
  • Pomalidomide-C2-NH2 hydrochloride
  • Cereblon Ligand-Linker Conjugates 15 (hydrochloride)
  • 4-[(2-aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl )-2,3-dihydro-1H-isoindole-1,3-dione hydrochloride
  • E3 ligase Ligand 17 hydrochloride
  • 4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
  • 4-(2-aminoethylamino)-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
  • Thalidomide-NH-C2-NH2.HCl
  • PomalidomideC2NH2 hydrochloride,inhibit,Inhibitor,Pomalidomide-C-2-NH2 hydrochloride,E3 Ligase Ligand-Linker Conjugates,Pomalidomide C2 NH2 hydrochloride,Cereblon Ligand-Linker Conjugates 15
  • 4-((2-aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride, 4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, E3 Ligase Ligand 17
  • Poma-C2-NH2·HCl
  • Thalidomide-4-NH-C2-NH2 HCl
  • 4-(2-aminoethylamino)-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
  • Pomalidomide 4'-alkylC2-amine
  • Pomalidomide-C<sub>2</sub>-NH<sub>2</sub> hydrochloride
  • 4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione Hydrochloride
  • Pomalidomide-C2-NH2 HCl
  • 2305369-00-8
  • C15H16N4O4ClH