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HUMAN IL-1BETA

Product Name
HUMAN IL-1BETA
CAS No.
97599-21-8
Chemical Name
HUMAN IL-1BETA
Synonyms
HUMAN EP;HUMAN MCF;HUMAN LAF;HUMAN LEM;HIL-1BETA;RHIL-1BETA;HUMAN IL-1B;IL-1B, HUMAN;HUMAN IL-1BETA;IL-1F2 (HUMAN)
CBNumber
CB3663589
Formula Weight
0
MOL File
Mol file
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HUMAN IL-1BETA Property

storage temp. 
-20°C
form 
lyophilized powder
color 
white to off-white
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Safety

WGK Germany 
3
RTECS 
NM9740000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SRP3083
Product name
IL-1 beta human
Purity
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Packaging
10μG
Price
$402
Updated
2024/03/01
Sigma-Aldrich
Product number
SRP6169
Product name
IL-1β human
Purity
recombinant,expressedinHEK293cells,≥95%(SDS-PAGE)
Packaging
10μg
Price
$468
Updated
2023/06/20
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HUMAN IL-1BETA Chemical Properties,Usage,Production

Uses

IL-1β (interleukin 1 β) human has been used to study the effect of pro- and anti-inflammatory mediators on leukotriene B4 and C4 synthesis as well as secretion in an inflamed porcine endometrium. It has been used to study the effect of cytokines on synthesis and secretion of leukotrienes from endometrial epithelial cells of pigs.

General Description

IL-1β (interleukin 1 β) is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. It is synthesized as a pro-IL-1β which is changed to active form IL-1β with the help of pro-inflammatory protease caspase-1. IL-1β belongs to the IL-1 gene family. The gene is mapped to human chromosome 2q14. Recombinant human IL-1β is a 17.3kDa protein containing 153 amino acid residues.

Biochem/physiol Actions

Both IL-1α (interleukin 1 α) and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF (fibroblast growth factor)-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. IL-1β is involved in proinflammatory and immunological responses. Some of them include enhancing IL-2 generation, and increasing circulating NO (nitric oxide) and bringing neutrophils. It also regulates gene expression of inflammatory cytokines, mesenchymal growth factors and colony stimulating factors. IL-1β is present in chronic inflamed tissues and also in tissues going for fibrogenesis. It brings neutrophil and macrophage to the site of infection. Mutations in IL-1β gene are linked with renal manifestations and renal sequelae in Henoch-Sch?nlein purpura. It is also associated with destruction of β-cell in type 1 diabetes.

HUMAN IL-1BETA Preparation Products And Raw materials

Raw materials

Preparation Products

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HUMAN IL-1BETA Suppliers

China 25 Germany 1 Japan 3 Switzerland 2 United Kingdom 1 United States 12 Global 44
Riedel-de Haen AG
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97599-21-8, HUMAN IL-1BETARelated Search:

TERT-BUTYL ISOCYANIDE 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Tris(2,4-pentanedionato)chroMiuM(III) N-BUTYLISOCYANIDE COBALT(II) ACETYLACETONATE Tosylmethyl isocyanide 2,4-PENTANEDIONE, SILVER DERIVATIVE METHYL ISOCYANOACETATE Aluminum acetylacetonate PHENYLSELENOL Benzyl isocyanide SALCOMINE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Ferric acetylacetonate Ethyl isocyanoacetate DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Cupric acetylacetonate

  • IL-1F2 (HUMAN)
  • IL-1B, HUMAN
  • IL-1 BETA, HUMAN
  • IL-1BETA IL-1 LYMPHOCYTE ACTIVATING FACTOR HUMAN
  • HUMAN MONONUCLEAR CELL FACTOR
  • HUMAN INTERLEUKIN-1BETA
  • HUMAN IL-1B
  • HUMAN IL-1BETA
  • HUMAN MCF
  • Interleukin-1β, Human, Recombinant, E. coli
  • RECOMBINANT HUMAN IL-1B
  • RHIL-1BETA
  • INTERLEUKIN,HUMAN,RECOMBINANT,CELLCULTUREGRADE
  • HUMAN LYMPHOCYTE-ACTIVATING FACTOR
  • HUMAN LEUKOCYTE ENDOGENOUS MEDIATOR
  • HUMAN LAF
  • HUMAN LEM
  • HUMAN ENDOGENOUS PYROGEN
  • HUMAN CATABOLIN
  • HUMAN EP
  • HIL-1BETA
  • INTERLEUKIN-1BETA, HUMAN
  • INTERLEUKIN-1BETA, HUMAN, RECOMBINANT
  • Interleukin-1beta (IL-1beta),human,recombinant
  • 98% (HPLC), suitable for cell culture
  • 97599-21-8