Sieber Linker

Product Name: Sieber Linker
CAS No.: 3722-51-8
Chemical Name: Sieber Linker
Synonyms: HF;3-Hydroxy-9H-xanthen-9-one;Sibur linker;SIEBER LINKER;3-HYDROXYXANTHONE;6-HYDROXY-3-FLUORONE;SALOR-INT L254835-1EA;3-HYDROXY-XANTHEN-9-ONE;SIEBER LINKER, 99% MIN.;3-hydroxy-9H-9-xanthenone
CBNumber: CB3710805
Molecular Formula: C13H8O3
Formula Weight: 212.2
MOL File: 3722-51-8.mol

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Sieber Linker Property

Melting point:: 243 °C
Boiling point:: 403.9±24.0 °C(Predicted)
Density: 1.395±0.06 g/cm3(Predicted)
storage temp.: Store at 0°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka: 7.52±0.20(Predicted)
form: Solid
color: White to Orange to Green
InChI: InChI=1S/C13H8O3/c14-8-5-6-10-12(7-8)16-11-4-2-1-3-9(11)13(10)15/h1-7,14H
InChIKey: XCJHDJAODLKGLG-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C=CC=C2)OC2=C1C=CC(O)=C2
CAS DataBase Reference: 3722-51-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
HS Code: 29329900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: H1269
Product name: 3-Hydroxyxanthen-9-one
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $35
Updated: 2024/03/01

TCI Chemical

Product number: H1269
Product name: 3-Hydroxyxanthen-9-one
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $107
Updated: 2024/03/01

Alfa Aesar

Product number: H63495
Product name: 3-Hydroxyxanthone, 98%
Packaging: 1g
Price: $49
Updated: 2022/04/27

Alfa Aesar

Product number: H63495
Product name: 3-Hydroxyxanthone, 98%
Packaging: 5g
Price: $191
Updated: 2022/04/27

TRC

Product number: S699028
Product name: SieberLinker
Packaging: 50mg
Price: $45
Updated: 2021/12/16

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Sieber Linker Chemical Properties,Usage,Production

Chemical Properties

White to off-white or grey powder

Uses

Sieber linker (3-Hydroxyxanthen-9-one) is a natural product of the trifluoroacetic acid group found in Hypericum sampsonii and Rhachidosorus mesosorus. It has antiplatelet and anti-inflammatory properties. It also inhibits the expression of tumour necrosis factor-α (TNF-α) in mice. The synthesis of TNF-α is inhibited by Sieber linker, which may be due to its ability to inhibit the enzyme phosphodiesterase 4 (PDE4). Sieber linker also inhibits the binding of PDL1 to dinucleotide phosphate (DNP) and has an inhibitory effect on cancer cells. This molecule can be used for the treatment of infectious diseases, such as malaria and tuberculosis, since it inhibits protein synthesis in bacteria.

Synthesis Reference(s)

Tetrahedron, 43, p. 3075, 1987 DOI: 10.1016/S0040-4020(01)86849-6

Purification Methods

Purify the xanthone by chromatography on SiO2 gel with pet ether/*benzene as eluent. Recrystallise it from *benzene or EtOH. The acetate has m 157-158o. [Itoh et al. J Am Chem Soc 107 4819 1985, Davies et al. J Org Chem 23 307 1958]. [Beilstein 18 H 46, 18 I 315, 18 II 29, 21 III/IV 601.]

Sieber Linker Preparation Products And Raw materials

Raw materials

Pyridine hydrochloride o-Anisoyl chloride Salicylic acid o-Anisic acid Phosphoric acid 1,3-Dimethoxybenzene Zinc chloride Phosphorus oxychloride Resorcinol Hydrochloric acid Phosphorus pentoxide

Preparation Products

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Sieber Linker Suppliers

Americas 1 China 169 Europe 2 Germany 3 India 10 Japan 1 United Kingdom 10 United States 23 Global 219

bioKEMIX Ltd

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Molekula Ltd

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Leancare Ltd.

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CARBONE SCIENTIFIC CO.,LTD

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ProdList: 6666
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MOLEKULA Ltd.

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Country: United Kingdom
ProdList: 6140
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ETA SCIENTIFIC Co.,Ltd

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Country: United Kingdom
ProdList: 6090
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UK GREEN SCIENTIFIC CO.,LIMITED

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ProdList: 6098
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Fluorochem Ltd

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Fluorochem Ltd.

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VWR International

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ProdList: 6548
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View Lastest Price from Sieber Linker manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Sieber Linker 3722-51-8
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-11

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Sieber Linker 3722-51-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-04-15

Suzhou Eebetter Biotechnology Co., Ltd.

Product: SieberLinker 3722-51-8
Price: US $70344.80-5944827.00/kg
Min. Order: 100kg
Purity: 99%
Supply Ability: 10 tons
Release date: 2023-08-30

3722-51-8, Sieber LinkerRelated Search:

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SIEBER LINKER

SALOR-INT L254835-1EA

HF

6-HYDROXY-3-FLUORONE

3-HYDROXY-XANTHEN-9-ONE

3-HYDROXYXANTHONE

3-Hydroxy-9H-xanthen-9-one

SIEBER LINKER,3-HYDROXY-XANTHEN-9-ONE

3-HYDROXY-XANTHEN-9-ONE SIEBER LINKER 99+%

SIEBER LINKER, 99% MIN.

3-hydroxy-9H-9-xanthenone

3-Hydroxy-9H-xanthen-9-one ,97%

Sieber linker≥ 99% (HPLC)

3-Hydroxyxanthen-9-one&gt

9H-Xanthen-9-one, 3-hydroxy-

Sieber Linker (3-Hydroxyxanthone) extrapure, 99%

Sibur linker

3722-51-8

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