ChemicalBook > CAS DataBase List > 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE

3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE

Product Name
3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE
CAS No.
140675-42-9
Chemical Name
3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE
Synonyms
3,5-DIFLUOROSALICYLALDEHYDE;3,5-DIFLUORO-2-HYDROXYACETOPHENONE;3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE;1-(3,5-Difluoro-2-hydroxyphenyl)ethanone;3',5'-Difluoro-2'-hydroxyacetophenone98%;3',5'-Difluoro-2'-hydroxyacetophenone 98%;3',5'-Difluoro-2'-hydroxyacetophenone,97%;1-(3,5-DIFLUORO-2-HYDROXYPHENYL)ETHAN-1-ONE;Ethanone, 1-(3,5-difluoro-2-hydroxyphenyl)-;1-(3,5-Difluoro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-4,6-difluorophenol
CBNumber
CB3725595
Molecular Formula
C8H6F2O2
Formula Weight
172.13
MOL File
140675-42-9.mol
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3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE Property

Melting point:
53-55°C
Boiling point:
220.8±35.0 °C(Predicted)
Density 
1.346±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
8.93±0.23(Predicted)
form 
powder
color 
Khaki/gold
CAS DataBase Reference
140675-42-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
Hazard Note 
Irritant
HS Code 
2914500090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D451703
Product name
3'',5''-Difluoro-2''-hydroxyacetophenone
Packaging
100mg
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
PC2826
Product name
3',5'-Difluoro-2'-hydroxyacetophenone
Purity
98%
Packaging
1g
Price
$16
Updated
2021/12/16
SynQuest Laboratories
Product number
2620-3-35
Product name
3',5'-Difluoro-2'-hydroxyacetophenone
Purity
98%
Packaging
1g
Price
$20
Updated
2021/12/16
Matrix Scientific
Product number
004372
Product name
3',5'-Difluoro-2'-hydroxyacetophenone
Purity
98%
Packaging
1g
Price
$38
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD86341
Product name
1-(3,5-Difluoro-2-Hydroxyphenyl)-Ethanone
Packaging
1g
Price
$50
Updated
2021/12/16
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3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE Chemical Properties,Usage,Production

Preparation

This compound can be easily obtained by Fries rearrangement of 2,4-difluorophenyl acetate with aluminium chloride without solvent at 150°, and purified by recrystallization from ethanol (80–90%) ; the 2,4-difluorophenyl acetate is prepared by reaction of acetic anhydride on 2,4-difluorophenol.

Synthesis

36914-77-9

140675-42-9

General procedure for the synthesis of 1-(3,5-difluoro-2-hydroxyphenyl)ethanone from 2,4-difluorophenyl acetate: a mixture of intermediate 362 (2 g, 11.6 mmol) and aluminum trichloride (2.8 g) was heated under argon protection at 150 °C for 30 min. After completion of the reaction, it was cooled to room temperature and ice water was added cautiously followed by dropwise addition of 1N aqueous hydrochloric acid solution. The mixture was decanted in the presence of toluene and the organic phase was separated and washed sequentially with water and saturated aqueous sodium chloride. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the solid product intermediate 363 (1.5 g). The product was characterized as follows: 1H NMR (300 MHz, CDCl3): δ 12.00 (m, 1H), 7.25 (m, 1H), 7.10 (m, 1H), 2.65 (s, 3H). ir (cm-1): 1651.

References

[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 22, p. 6569 - 6584
[2] Patent: US2017/137385, 2017, A1. Location in patent: Paragraph 0279; 0283; 0284; 0285
[3] Patent: US6191164, 2001, B1

3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE Suppliers

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View Lastest Price from 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE manufacturers

Career Henan Chemical Co
Product
3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE 140675-42-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-14

140675-42-9, 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONERelated Search:

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 4-Fluoro-2-methylphenol 2,4-Difluorophenol 3'-Fluoroacetophenone 4-Fluorophenol 5,7-DIFLUORO-BENZOFURAN-3-ONE 5-Fluorosalicylaldehyde 3-Fluoro-2-hydroxybenzaldehyde 1-Ethyl-3,5-difluorobenzene 3''-Fluoro-2''-Hydroxyacetophenone 2-Fluorophenol 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE 2-ETHYL-4-FLUOROPHENOL 3',5'-Difluoroacetophenone 2',4'-DIFLUORO-2-HYDROXYACETOPHENONE 3'',5''-Difluoro-4''-Hydroxyacetophenone 3 5-DIFLUOROSALICYLALDEHYDE 97 5,6,7,8-TETRAFLUORO-2-METHYL-4-OXO-4H-CHROMENE-3-CARBOXYLIC ACID ETHYL ESTER

  • 1-(3,5-DIFLUORO-2-HYDROXYPHENYL)ETHAN-1-ONE
  • 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE
  • 3,5-DIFLUORO-2-HYDROXYACETOPHENONE
  • 3,5-DIFLUOROSALICYLALDEHYDE
  • 3',5'-Difluoro-2'-hydroxyacetophenone 98%
  • 3',5'-Difluoro-2'-hydroxyacetophenone98%
  • 1-(3,5-Difluoro-2-hydroxyphenyl)ethanone
  • 1-(3,5-Difluoro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-4,6-difluorophenol
  • Ethanone, 1-(3,5-difluoro-2-hydroxyphenyl)-
  • 3',5'-Difluoro-2'-hydroxyacetophenone,97%
  • 140675-42-9
  • 40675-42-9
  • Aromatic Acetophenones & Derivatives (substituted)