THIAMINE HYDROCHLORIDE Property

Melting point:

250 °C (dec.)(lit.)

storage temp. 

2-8°C

solubility 

H₂O: 0.1 g/mL at 20 °C, clear, colorless

BCS Class

3

Safety

Safety Statements 

22-24/25

WGK Germany 

1

RTECS 

XI7350000

F 

3-8-10

HS Code 

29362200

Hazard and Precautionary Statements (GHS)

THIAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Physical properties

Free thiamin is unstable because of its quaternary nitrogen; in water, it is cleaved to the thiol form. For this reason, the hydrochloride and mononitrate forms are used in commerce. Thiamin hydrochloride (actually, thiamin chloride hydrochloride) is a colorless crystal that is very soluble in water (1 g/ml, thus making it a very suitable form for parenteral administration), soluble in methanol and glycerol, but practi cally insoluble in acetone, ether, chloroform, and benzene. The mononitrate form is more stable than the hydrochloride form, but it is less soluble in water. It is used in food/feed supplementation and in dry pharmaceutical preparations. Free thiamin is easily oxidized to thiamin disulfide and other derivatives, including thiochrome, a yellow biologically inactive product with strong blue fluorescence that can be used for the quantitative determination of thiamin. Its metabolically active form is thia min diphosphate, also called thiamin pyrophosphate.

Definition

ChEBI: Thiamine(1+) is a primary alcohol that is 1,3-thiazol-3-ium substituted by (4-amino-2-methylpyrimidin-5-yl)methyl, methyl and 2-hydroxyethyl groups at positions 3, 4 and 5, respectively. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a primary alcohol and a vitamin B1. It is a conjugate base of a thiamine(2+).