ChemicalBook > CAS DataBase List > (S)-(+)-2-Methylpiperazine

(S)-(+)-2-Methylpiperazine

Product Name
(S)-(+)-2-Methylpiperazine
CAS No.
74879-18-8
Chemical Name
(S)-(+)-2-Methylpiperazine
Synonyms
S-MP;CADR-011;L-(+)-2-Meth;(S)-2-METHYLPIPERAZINE;2-(S)-METHYLPIPERAZINE;(2S)-2-Methylpiperazine;L-(+)-2-Methylpiperazine;S-(+)-2-methylpyperazine;(S)-(+)-2-METHYLPIPERZINE;(S)-(+)-2-METHYLPIPERAZINE
CBNumber
CB3781696
Molecular Formula
C5H12N2
Formula Weight
100.16
MOL File
74879-18-8.mol
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(S)-(+)-2-Methylpiperazine Property

Melting point:
91-93 °C(lit.)
Boiling point:
155-156 °C
alpha 
13.5 º (c=1, toluene)
Density 
0.9305 (estimate)
refractive index 
1.4378 (estimate)
Flash point:
149 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
Crystalline Powder, Crystals and/or Chunks
pka
9.31±0.40(Predicted)
color 
White to yellow
optical activity
[α]20/D +6.8°, c = 1 in ethanol
Water Solubility 
soluble
Sensitive 
Air Sensitive & Hygroscopic
BRN 
3647995
InChIKey
JOMNTHCQHJPVAZ-YFKPBYRVSA-N
CAS DataBase Reference
74879-18-8(CAS DataBase Reference)
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Safety

Hazard Codes 
F,Xi,C
Risk Statements 
11-36/37/38-34
Safety Statements 
16-26-36/37/39-45-36
RIDADR 
UN 1325 4.1/PG 2
WGK Germany 
3
RTECS 
TM1225020
HazardClass 
4.1
PackingGroup 
III
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
397172
Product name
(S)-(+)-2-Methylpiperazine
Purity
99%
Packaging
1g
Price
$25
Updated
2023/06/20
Sigma-Aldrich
Product number
397172
Product name
(S)-(+)-2-Methylpiperazine
Purity
99%
Packaging
5g
Price
$91.5
Updated
2023/06/20
TCI Chemical
Product number
M1424
Product name
(S)-(+)-2-Methylpiperazine
Purity
>97.0%(T)
Packaging
1g
Price
$79
Updated
2025/07/31
TCI Chemical
Product number
M1424
Product name
(S)-(+)-2-Methylpiperazine
Purity
>97.0%(T)
Packaging
5g
Price
$164
Updated
2025/07/31
TRC
Product number
M302705
Product name
(2S)-2-Methylpiperazine
Packaging
5g
Price
$60
Updated
2021/12/16
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(S)-(+)-2-Methylpiperazine Chemical Properties,Usage,Production

Chemical Properties

white to yellow crystalline powder or chunks

Uses

Valuable synthon for quinoline antibacterials.

Synthesis

109-07-9

75336-86-6

74879-18-8

General procedure for the synthesis of (R)-(-)-2-methylpiperazine and (S)-2-methylpiperazine from 2-methylpiperazine: 1. In a 2L four-necked flask equipped with a thermometer, a vacuum stirrer and a cooling tube, 270 g (1.8 mol) of L-tartaric acid, 108 g (1.8 mol) of acetic acid and 270 g of water were added and stirred until completely dissolved. 2. add (±)-2-methylpiperazine 300 g (3.0 mol) and water 300 g. Heat to 85 °C or higher until completely dissolved. 3. cool to 68-74°C, add diastereomerically precipitated crystals of (R)-2-methylpiperazine and L-tartaric acid and age for 1 hour. 4. cooled to 12-18 °C over 5 h and filtered to obtain 440 g of wet biomass (diastereomeric salt) with a liquid content of 22.7 wt% and an optical purity of 92.3% ee. 5. 644 g of water and 440 g of the resulting crystals ((R)-2-methylpiperazine pure content = 132 g) were added to a 2L four-neck flask, followed by 162 g (2.2 mol) of calcium hydroxide, heated to 80 °C, and aged for 5 hours. 6. Cooled to 25 °C and filtered to give 586 g of crystals (mainly calcium L-tartrate) and 660 g of filtrate (containing 130 g of (R)-2-methylpiperazine). 7. The filtrate was concentrated under reduced pressure to a (R)-2-methylpiperazine concentration of 30%, 356 g of toluene was added, and the water was removed by azeotropic boiling by heating to 84-87 °C. 8. 212 g of toluene was distilled under reduced pressure, cooled to 47 °C, 0.01 g of (R)-2-methylpiperazine crystal seed was added and aged for 1 hour. 9. cooled to 5 °C, aged for 2 h, filtered and dried under vacuum to give 45 g of (R)-2-methylpiperazine crystals (chemical purity 100%, optical purity 99.5% ee). 10. For the synthesis of (S)-2-methylpiperazine, a similar procedure was used but with (S)-2-methylpiperazine as starting material, resulting in 66.8 g of (S)-2-methylpiperazine crystals (chemical purity 99.9%, optical purity 80.0%ee).

References

[1] Patent: JP2016/37495, 2016, A. Location in patent: Paragraph 0046-0052

(S)-(+)-2-Methylpiperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(+)-2-Methylpiperazine Suppliers

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View Lastest Price from (S)-(+)-2-Methylpiperazine manufacturers

Career Henan Chemical Co
Product
(S)-(+)-2-Methylpiperazine 74879-18-8
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-08-08
Career Henan Chemical Co
Product
(S)-(+)-2-Methylpiperazine 74879-18-8
Price
US $1.00/kg
Min. Order
1kg
Purity
As customer's need
Supply Ability
CARA34
Release date
2018-12-14

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