3,4,5-Trimethoxyaniline
- Product Name
- 3,4,5-Trimethoxyaniline
- CAS No.
- 24313-88-0
- Chemical Name
- 3,4,5-Trimethoxyaniline
- Synonyms
- 3,4,5-Trimethoxy;3,4,5-trimethoxy-benzenamin;3,4,5-triMethoxybenzenaMine;NSC 37006;TriMethoxyaniline;5-Trimethoxyaniline;3,4,5-TrimethoxyaniL;4,5-Trimethoxyaniline;3,4,5-TRIMETHOXYANILINE;3,4,5-TRIMOTHOXYANILINE
- CBNumber
- CB4117296
- Molecular Formula
- C9H13NO3
- Formula Weight
- 183.2
- MOL File
- 24313-88-0.mol
3,4,5-Trimethoxyaniline Property
- Melting point:
- 110-113 °C (lit.)
- Boiling point:
- 316.88°C (rough estimate)
- Density
- 1.1967 (rough estimate)
- refractive index
- 1.4760 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 4.35±0.10(Predicted)
- form
- Powder
- color
- Off-white to beige-brown, gray, or pink
- BRN
- 642919
- InChI
- InChI=1S/C9H13NO3/c1-11-7-4-6(10)5-8(12-2)9(7)13-3/h4-5H,10H2,1-3H3
- InChIKey
- XEFRNCLPPFDWAC-UHFFFAOYSA-N
- SMILES
- C1(N)=CC(OC)=C(OC)C(OC)=C1
- CAS DataBase Reference
- 24313-88-0(CAS DataBase Reference)
- EPA Substance Registry System
- 3,4,5-Trimethoxyaniline (24313-88-0)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 37/38-36/37/38-20/21/22
- Safety Statements
- 22-24/25-37/39-26-24-36
- RIDADR
- 2811
- WGK Germany
- 3
- Hazard Note
- Harmful
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29222900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- T68209
- Product name
- 3,4,5-Trimethoxyaniline
- Purity
- 97%
- Packaging
- 10g
- Price
- $60.4
- Updated
- 2025/07/31
- Product number
- T68209
- Product name
- 3,4,5-Trimethoxyaniline
- Purity
- 97%
- Packaging
- 25g
- Price
- $86.3
- Updated
- 2025/07/31
- Product number
- T1055
- Product name
- 3,4,5-Trimethoxyaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $68
- Updated
- 2025/07/31
- Product number
- T1055
- Product name
- 3,4,5-Trimethoxyaniline
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $318
- Updated
- 2025/07/31
- Product number
- T795670
- Product name
- 3,4,5-Trimethoxyaniline
- Packaging
- 10g
- Price
- $70
- Updated
- 2021/12/16
3,4,5-Trimethoxyaniline Chemical Properties,Usage,Production
Chemical Properties
3,4,5-Trimethoxyaniline is off-white to beige-brown, grey or pink powder
Uses
3,4,5-Trimethoxyaniline is a tri-substituted aniline derivative with sympatholytic activity. It is used in the preparation of a novel class of anticancer agents.
Application
3,4,5-Trimethoxyaniline can be used:
(1) As experimental studies, infrared spectra and laser Raman spectra of 3,4,5-trimethoxyaniline were investigated[1].
(2) Tropanilisation, detropanilisation and Schiff base formation in the reaction of 3,4,5-trimethoxyaniline with tropanilide ions as organic reaction reagents[2].
Application
[1] BANDANA SHARMA; Shweta P; Munish Kumar Yadav. MOLECULAR STRUCTURE, EXPERIMENTAL AND THEORETICAL (HF, DFT) SPECTRAL ANALYSIS OF 3,4,5- TRIMETHOXYANILINE[J]. Rasayan Journal of Chemistry, 2023. DOI:10.31788/rjc.2023.1628371.
[2] J. TSUNETSUGU; S. E; M SATO. ChemInform Abstract: TROPENYLATION, DETROPENYLATION AND SCHIFF BASE FORMATION IN THE REACTION OF 3,4,5-TRIMETHOXYANILINE WITH TROPENYLIUM ION[J]. ChemInform, 1975. DOI:10.1002/chin.197545221.
Synthesis
6307-90-0
24313-88-0
Step B / Intermediate B9: Synthesis of 3,4,5-trimethoxyaniline To a solution of 1,2,3-trimethoxy-5-nitrobenzene (6.64 g, 31.2 mmol) in ethanol (250 mL) was added palladium carbon (10%, 300 mg) and hydrazine hydrate (85%, 5.7 mL). The reaction mixture was heated to reflux for 1 hour after gas release ceased. Upon completion of the reaction, the mixture was cooled to room temperature and the catalyst was removed by filtration followed by evaporation of the solvent to afford 3,4,5-trimethoxyaniline (5.5 g, 96.4% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 5.86 (s, 2H), 4.82 (br, 2H), 3.64 (s, 6H), 3.50 (s, 3H).
References
[1] Patent: WO2012/92880, 2012, A1. Location in patent: Page/Page column 60
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 9, p. 3414 - 3425
[3] Chemische Berichte, 1888, vol. 21, p. 615
[4] Australian Journal of Scientific Research, Series A: Physical Sciences, 1950, vol. 3, p. 467,500
[5] Journal of Pharmacy and Pharmacology, 1958, vol. 10, p. 47,59
3,4,5-Trimethoxyaniline Preparation Products And Raw materials
Raw materials
Preparation Products
3,4,5-Trimethoxyaniline Suppliers
- Tel
- --
- Fax
- --
- unachem@ktnet.co.kr
- Country
- South Korea
- ProdList
- 1181
- Advantage
- 30
View Lastest Price from 3,4,5-Trimethoxyaniline manufacturers
- Product
- 3,4,5-Trimethoxyaniline 24313-88-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2025-03-10
- Product
- 3,4,5-Trimethoxyaniline 24313-88-0
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-18
- Product
- 3,4,5-Trimethoxyaniline 24313-88-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27