4-Methylpiperidine Property

Melting point:

4-5 °C

Boiling point:

124 °C(lit.)

Density 

0.838 g/mL at 25 °C(lit.)

vapor pressure 

16 hPa (20 °C)

refractive index 

n20/D 1.446(lit.)

Flash point:

45 °F

storage temp. 

Flammables area

solubility 

Chloroform

form 

Liquid

pka

pK1:11.23(+1) (25°C,μ=0.5)

Specific Gravity

0.838

color 

Clear slightly yellow

PH

13 (100g/l, H2O, 20℃)

Water Solubility 

miscible

BRN 

1083

CAS DataBase Reference

626-58-4(CAS DataBase Reference)

NIST Chemistry Reference

Piperidine, 4-methyl-(626-58-4)

EPA Substance Registry System

Piperidine, 4-methyl- (626-58-4)

Safety

Hazard Codes 

F,Xi,T

Risk Statements 

11-36/37/38-36-20/21-10-61

Safety Statements 

16-26-36-45-36/37-53

RIDADR 

UN 1993 3/PG 2

WGK Germany 

3

TSCA 

Yes

HazardClass 

3

PackingGroup 

II

HS Code 

29333999

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

4-Methylpiperidine Chemical Properties,Usage,Production

Chemical Properties

clear slightly yellow liquid

Uses

4-Methylpiperidine acts as a catalyst in the preparation of stilbene derivatives. It is used as an anti-corrosive compound for iron. It is also used in the synthesis of peptides to remove or deprotection of 9-fluorenylmethyloxycarbonyl (Fmoc) groups.

Uses

4-Methylpiperidine is used as a catalyst in the synthesis of stilbene derivatives as anti-malarial agents. It also serves as an anti-corrosive compound for iron.

Purification Methods

Purify it via the hydrochloride (m 189o). It is freed from 3-methylpyridine by zone melting. The hydrobromide has m 173o(from butanone/*C6H6). [Beilstein 20 III/IV 1511, 20/4 V 116.]