7S-NERVE GROWTH FACTOR, MOUSE

Discovery Structure Properties Gene, mRNA, and precursor Synthesis and release Receptors Biological functions

Product Name: 7S-NERVE GROWTH FACTOR, MOUSE
CAS No.: 9061-61-4
Chemical Name: 7S-NERVE GROWTH FACTOR, MOUSE
Synonyms: NGF;7S-NGF;MNGF 7S;NGF (7S);NGF-beta;SNAKE NGF;MOUSE NGF-7S;7S-NGF MOUSE;NGF 7S (MOUSE);NERVE GROWTH FACTOR
CBNumber: CB4141329
Formula Weight: 0
MOL File: Mol file

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7S-NERVE GROWTH FACTOR, MOUSE Property

storage temp.: −20°C
form: lyophilized powder
color: white to off-white
biological source: rabbit

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SAB1306570
Product name: ANTI-NGFB (CENTER) antibody produced in rabbit
Purity: purified immunoglobulin, buffered aqueous solution
Packaging: 400μl
Price: $481
Updated: 2024/03/01

Sigma-Aldrich

Product number: N8133
Product name: Nerve Growth Factor from Vipera lebetina venom
Purity: NGF, lyophilized powder, suitable for cell culture
Packaging: 0.1mg
Price: $262
Updated: 2024/03/01

Usbiological

Product number: 357613
Product name: NGF
Packaging: 48Tests
Price: $588
Updated: 2021/12/16

Usbiological

Product number: 357617
Product name: NGF
Packaging: 48Tests
Price: $588
Updated: 2021/12/16

Usbiological

Product number: 357615
Product name: NGF
Packaging: 48Tests
Price: $588
Updated: 2021/12/16

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7S-NERVE GROWTH FACTOR, MOUSE Chemical Properties,Usage,Production

Discovery

NGF is the first member of neurotrophins. In the first half of the 20th century, it had been experimentally demonstrated in embryos that the nonneuronal “periphery” is essential for the differentiation of the sensory and motor centers of the central nervous system and the sensory ganglia. By 1951, Rita Levi-Montalcini and Viktor Hamburger discovered that certain mouse tumors release a “substance” that induces nerve fibers to grow in a chick embryo. With Stanley Cohen, they isolated “nerve growth-stimulating factor,” a preparation containing both protein and nucleic acid. Subsequently, “nerve growth factor” was purified from snake venom and mouse salivary glands, and identified as a protein. Its complete amino acid sequence was determined in 1971.

Structure

NGF consists of three types of subunits, α, β, and γ, which specifically interact to form a 7S, 130-kDa complex. The 7S complex contains two identical β-subunits. Among the three types of subunits, β-subunit only has bioactivity and therefore is referred to as NGF. The human NGF gene (β-subunit, β-NGF) encodes a preproprotein of 241 aa residues (preproNGF) . After cleavage by the protease activity of the γ-subunit, a 120-aa peptide of NGF (β-subunit), which has biological activity, is generated. The β-subunit dimerizes through noncovalent interaction, and presents as a 2.5S, 26-kDa protein. NGF has been identified in mammals, birds, reptiles, amphibians, and teleosts. Six cysteines involved in the intramolecular disulfide bond are conserved among all vertebrate NGFs.

Properties

Mr. 26,518 (mouse preproNGF); 13,259 (mouse mature NGF). pI 9.3. NGF is soluble in water. Disulfide bridges are formed between Cys15 and Cys80, between Cys58 and Cys108, and between Cys68 and Cys110 (in mammalian mature NGFs).

Gene, mRNA, and precursor

The human preproNGF (β-NGF) gene, NGF, location 1p13.2, consists of three exons. Human NGF mRNA has 1061 bases that encode a preproNGF of 241 aa residues. ProNGF shows broad expression in the ovary (RPKM 1.3), the heart (RPKM 0.5), and 18 other tissues, including the brain.

Synthesis and release

The expression of the NGF gene is regulated by the developmental stage, neuronal innervation, and neuronal activity. NGF mRNA levels are increased during postnatal development in the rat hippocampus and basal ganglia. Both continuous release and neuronal activity-dependent release are reported. The release from cultured hippocampal neurons is enhanced more than three-fold within several minutes by a depolarizing stimulus.

Receptors

NGF binds to at least two classes of receptors: tropomyosin receptor kinase A (TrkA), the high-affinity receptor, and p75NTR, the low affinity receptor. Both TrkA and p75NTR are single-transmembrane receptors. The human NTRK1 gene encodes TrkA (Trk1) of 790 aa residues. The human NGFR gene encodes p75NTR of 427 aa residues. TrkA has a tyrosine-kinase domain in the cytoplasmic region. p75NTR has no tyrosine-kinase domain. The binding activity of mature NGF: Kd=10 pM (TrkA) and 1 nM (p75NTR). ProNGF also binds to p75NTR (Kd: 100 pM) and TrkA (Kd: 1 nM).

Biological functions

Both TrkA and p75NTR are expressed in sensory neurons, sympathetic neurons, and cholinergic neurons. The activation of TrkA induces the survival of these neurons, promotes outgrowth of the neurite, and stimulates the synthesis of neurotransmitters. The involvement of p75NTR in apoptosis is observed in the avian retina, mouse basal forebrain, and rat cerebral cortex. p75NTR-mediated apoptosis of the rat oligodendrocytes is induced specifically by NGF but not by other neurotrophins.

Description

NGF is the first member of the neurotrophin-family trophic factors. NGF regulates the growth, maintenance, proliferation, and survival of certain target neurons through activation of the high affinity receptor, tropomyosin receptor kinase A (TrkA). NGF is also involved in apoptosis through binding to the low affinity receptor, p75NTR. NGF consists of three types of subunits, α, β, and γ, and the β-subunit is solely responsible for the nerve growth stimulating activity of NGF.

Clinical Use

NGF is now known to have therapeutic potential on peripheral and central nervous system diseases but also on the visual system, cutaneous wound healing, and the regulation of immune system functions. NGF shows protective effects on cholinergic neurons in the brains of Alzheimer’s disease model animals. NGF also shows promoting effects on neurite outgrowth in the aged human and rat.

7S-NERVE GROWTH FACTOR, MOUSE Preparation Products And Raw materials

Raw materials

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7S-NERVE GROWTH FACTOR, MOUSE Suppliers

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9061-61-4, 7S-NERVE GROWTH FACTOR, MOUSERelated Search:

1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE Ethyl isocyanoacetate SALCOMINE Cupric acetylacetonate N-BUTYLISOCYANIDE METHYL ISOCYANOACETATE DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Tosylmethyl isocyanide TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) Aluminum acetylacetonate COBALT(II) ACETYLACETONATE Tris(2,4-pentanedionato)chroMiuM(III) 2,4-PENTANEDIONE, SILVER DERIVATIVE PHENYLSELENOL TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III) Benzyl isocyanide TERT-BUTYL ISOCYANIDE nerve growth factor-β human

MNGF 7S

MOUSE NGF-7S

NGF

7S-NERVE GROWTH FACTOR, MOUSE

7S NERVE GROWTH FACTOR, MOUSE SUBMAXILLARY GLANDS

7S-NGF

7S-NGF MOUSE

TNFRSF 16 7S (MOUSE)

NGF (7S)

NGF 7S (MOUSE)

NERVE GROWTH FACTOR

NERVE GROWTH FACTOR 7.0S

NERVE GROWTH FACTOR 7S (MOUSE)

NERVE GROWTH FACTOR SNAKE VENOM

SNAKE NGF

nerve growth factor from mouse submaxil-lary gland

nerve growth factor from vipera*lebetina venom st

NERVE GROWTH FACTOR FROM VIPERA*LEBETINA VENOM STER

nerve growth factor from vipera lebetina venom

NERVEGROWTHFACTOR(FROMSNAKEVENOM)

7S-NERVE GROWTH FACTOR, FROM MOUSE SUBMAXILLARY GLANDS

Nerve Growth Factor-β from rat

Nerve growth factor, recombinant

NGF-beta

ANTI-NGFB (CENTER) antibody produced in rabbit

NGF-beta from mouse

NGF, Nerve Growth Factor

9061-61-4

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Cytokines and Growth Factors

Cytokines, Growth Factors and Hormones

Nerve Growth Factor (NGF) and Neurotrophins

Neurotrophic Factors

Growth FactorsCytokines and Growth Factors

Growth FactorsStem Cell Expansion

Nerve Growth Factor (NGF) and NeurotrophinsNeural Stem Cell Biology

Nerve Growth Factors/CytokinesReagents and Supplements

Cytokines/Growth Factors/Chemokines

Growth Factors and Cytokines

Neural Stem Cell Isolation/Expansion

Neurotrophic Factors

Stem Cell Differentiation