ChemicalBook > CAS DataBase List > Dihydrochelerythrine

Dihydrochelerythrine

Product Name
Dihydrochelerythrine
CAS No.
6880-91-7
Chemical Name
Dihydrochelerythrine
Synonyms
Dihydrochelerythrine;Sibutramine Impurity 8;12,13-Dihydrochelerythrine;Dihydrochelerythrine, 10 mM in DMSO;Dihydrochelerythrine (12,13-Dihydrochelerythrine);1,2-dimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridine;1,2-dimethoxy-12-methyl-12,13-dihydro[1,3]benzodioxolo[5,6-c]phenanthridine;12,13-Dihydro-1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridine;12,13-Dihydro-1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridine;[1,3]Benzodioxolo[5,6-c]phenanthridine, 12,13-dihydro-1,2-dimethoxy-12-methyl-
CBNumber
CB41470176
Molecular Formula
C21H19NO4
Formula Weight
349.38
MOL File
6880-91-7.mol
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Dihydrochelerythrine Property

Melting point:
164-165 °C
Boiling point:
565.9±50.0 °C(Predicted)
Density 
1.291±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO : 50 mg/mL (143.11 mM; Need ultrasonic and warming)
form 
Powder
pka
2.36±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
30118
Product name
Dihydrochelerythrine
Packaging
1mg
Price
$47
Updated
2024/03/01
Cayman Chemical
Product number
30118
Product name
Dihydrochelerythrine
Packaging
25mg
Price
$505
Updated
2024/03/01
Cayman Chemical
Product number
30118
Product name
Dihydrochelerythrine
Packaging
5mg
Price
$171
Updated
2024/03/01
Cayman Chemical
Product number
30118
Product name
Dihydrochelerythrine
Packaging
10mg
Price
$315
Updated
2024/03/01
TRC
Product number
D447235
Product name
Dihydrochelerythrine
Packaging
1mg
Price
$55
Updated
2021/12/16
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Dihydrochelerythrine Chemical Properties,Usage,Production

Description

Dihydrochelerythrine is a benzophenanthridine alkaloid that has been found in Bocconia arborea and has diverse biological activities. It is active against S. aureus, S. faecalis, and C. albicans (MIC = 1.87 μg/ml for all). Dihydrochelerythrine inhibits secretion of the hepatitis B virus (HBV) antigens HBsAg and HBeAg from HepG2 2.2.15 cells (IC50s = <0.05 μM for both). It is cytotoxic to HCT8, BGC-823, and A2780 cancer cells (IC50s = 1.4, 0.4, and 3.5 μM, respectively).

Chemical Properties

Free dihydrochelerythrine crystals are insoluble in water, slightly soluble in methanol, and readily soluble in chloroform and dichloromethane. Dihydrochelerythrine is slowly and directly converted to chelerythrine in polar deuterium-substituting reagents (e.g., DMSO-d6 and MeOD), and in low-polarity deuterium-substituting reagents (e.g., CD2Cl2), it produces pseudo-bases and dimer intermediates, which are eventually oxidized to chelerythrine oxide.

Uses

Dihydrochelerythrine is synthesized as a potential G-quadrulpex DNA stabilizing agent. It is used in phamacokinetic study of chelerythrine metabolites in agro-products.

Definition

ChEBI: Dihydrochelerythrine is a benzophenanthridine alkaloid.

References

[1] VICTOR NAVARRO  Guillermo D. Two antimicrobial alkaloids from Bocconia arborea[J]. Journal of ethnopharmacology, 1999, 66 2: Pages 223-226. DOI: 10.1016/s0378-8741(98)00182-2
[2] YING-RUI WU. Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola.[J]. Planta medica, 2007, 73 8: 787-791. DOI: 10.1055/s-2007-981549
[3] AN-JUN DENG  Hai lin Q. Cytotoxic dihydrobenzophenanthridine alkaloids from the roots of Macleaya microcarpa[J]. Phytochemistry, 2010, 71 7: Pages 816-822. DOI: 10.1016/j.phytochem.2010.02.007

Dihydrochelerythrine Preparation Products And Raw materials

Raw materials

Preparation Products

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Dihydrochelerythrine Suppliers

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View Lastest Price from Dihydrochelerythrine manufacturers

Career Henan Chemical Co
Product
Dihydrochelerythrine 6880-91-7
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-14

6880-91-7, DihydrochelerythrineRelated Search:

Ethoxysanguinarine Sophocarpine DIHYDROSANGUINARINE 6-Methoxydihydrosanguinarine angoline ALLOCRYPTOPINE 6-Methoxyldihydrochelerythrine chloride Kalopanaxsaponin G Glomeratose A Pinocembrin 7-O-beta-D-glucoside chrysosplenetin B Norchelerythrine CHELERYTHRINE CHLORIDE Phenanthridine Chelerythrine

  • Dihydrochelerythrine (12,13-Dihydrochelerythrine)
  • Dihydrochelerythrine
  • 12,13-Dihydro-1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridine
  • 12,13-Dihydro-1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridine
  • 12,13-Dihydrochelerythrine
  • [1,3]Benzodioxolo[5,6-c]phenanthridine, 12,13-dihydro-1,2-dimethoxy-12-methyl-
  • 1,2-dimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridine
  • 1,2-dimethoxy-12-methyl-12,13-dihydro[1,3]benzodioxolo[5,6-c]phenanthridine
  • Sibutramine Impurity 8
  • Dihydrochelerythrine, 10 mM in DMSO
  • 6880-91-7