Dihydrochelerythrine
- Product Name
- Dihydrochelerythrine
- CAS No.
- 6880-91-7
- Chemical Name
- Dihydrochelerythrine
- Synonyms
- Dihydrochelerythrine;Sibutramine Impurity 8;12,13-Dihydrochelerythrine;Dihydrochelerythrine, 10 mM in DMSO;Dihydrochelerythrine (12,13-Dihydrochelerythrine);1,2-dimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridine;1,2-dimethoxy-12-methyl-12,13-dihydro[1,3]benzodioxolo[5,6-c]phenanthridine;12,13-Dihydro-1,2-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridine;12,13-Dihydro-1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridine;[1,3]Benzodioxolo[5,6-c]phenanthridine, 12,13-dihydro-1,2-dimethoxy-12-methyl-
- CBNumber
- CB41470176
- Molecular Formula
- C21H19NO4
- Formula Weight
- 349.38
- MOL File
- 6880-91-7.mol
Dihydrochelerythrine Property
- Melting point:
- 164-165 °C
- Boiling point:
- 565.9±50.0 °C(Predicted)
- Density
- 1.291±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO : 50 mg/mL (143.11 mM; Need ultrasonic and warming)
- form
- Powder
- pka
- 2.36±0.20(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 30118
- Product name
- Dihydrochelerythrine
- Packaging
- 1mg
- Price
- $47
- Updated
- 2024/03/01
- Product number
- 30118
- Product name
- Dihydrochelerythrine
- Packaging
- 25mg
- Price
- $505
- Updated
- 2024/03/01
- Product number
- 30118
- Product name
- Dihydrochelerythrine
- Packaging
- 5mg
- Price
- $171
- Updated
- 2024/03/01
- Product number
- 30118
- Product name
- Dihydrochelerythrine
- Packaging
- 10mg
- Price
- $315
- Updated
- 2024/03/01
- Product number
- D447235
- Product name
- Dihydrochelerythrine
- Packaging
- 1mg
- Price
- $55
- Updated
- 2021/12/16
Dihydrochelerythrine Chemical Properties,Usage,Production
Description
Dihydrochelerythrine is a benzophenanthridine alkaloid that has been found in Bocconia arborea and has diverse biological activities. It is active against S. aureus, S. faecalis, and C. albicans (MIC = 1.87 μg/ml for all). Dihydrochelerythrine inhibits secretion of the hepatitis B virus (HBV) antigens HBsAg and HBeAg from HepG2 2.2.15 cells (IC50s = <0.05 μM for both). It is cytotoxic to HCT8, BGC-823, and A2780 cancer cells (IC50s = 1.4, 0.4, and 3.5 μM, respectively).
Chemical Properties
Free dihydrochelerythrine crystals are insoluble in water, slightly soluble in methanol, and readily soluble in chloroform and dichloromethane. Dihydrochelerythrine is slowly and directly converted to chelerythrine in polar deuterium-substituting reagents (e.g., DMSO-d6 and MeOD), and in low-polarity deuterium-substituting reagents (e.g., CD2Cl2), it produces pseudo-bases and dimer intermediates, which are eventually oxidized to chelerythrine oxide.
Uses
Dihydrochelerythrine is synthesized as a potential G-quadrulpex DNA stabilizing agent. It is used in phamacokinetic study of chelerythrine metabolites in agro-products.
Definition
ChEBI: Dihydrochelerythrine is a benzophenanthridine alkaloid.
References
[1] VICTOR NAVARRO Guillermo D. Two antimicrobial alkaloids from Bocconia arborea[J]. Journal of ethnopharmacology, 1999, 66 2: Pages 223-226. DOI: 10.1016/s0378-8741(98)00182-2
[2] YING-RUI WU. Two new quaternary alkaloids and anti-hepatitis B virus active constituents from Corydalis saxicola.[J]. Planta medica, 2007, 73 8: 787-791. DOI: 10.1055/s-2007-981549
[3] AN-JUN DENG Hai lin Q. Cytotoxic dihydrobenzophenanthridine alkaloids from the roots of Macleaya microcarpa[J]. Phytochemistry, 2010, 71 7: Pages 816-822. DOI: 10.1016/j.phytochem.2010.02.007
Dihydrochelerythrine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Dihydrochelerythrine manufacturers
- Product
- Dihydrochelerythrine 6880-91-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-14