ChemicalBook > CAS DataBase List > 1,3-Benzodioxole

1,3-Benzodioxole

Product Name
1,3-Benzodioxole
CAS No.
274-09-9
Chemical Name
1,3-Benzodioxole
Synonyms
Benzo[d][1,3]dioxole;Benzodioxole;1,2-METHYLENEDIOXYBENZENE;1,2-Methylenedioxybenzene (MDB);1,3-DIOXAINDANE;1,3-BENZODIOXOL;BENZO[1,3]DIOXOLE;1,2-METHYLENDIOXYBENZENE;3,4-METHYLENEDIOXYBENZENE;MDB
CBNumber
CB4180652
Molecular Formula
C7H6O2
Formula Weight
122.12
MOL File
274-09-9.mol
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1,3-Benzodioxole Property

Melting point:
-18 °C
Boiling point:
172-173 °C(lit.)
Density 
1.064 g/mL at 25 °C(lit.)
vapor pressure 
12 mm Hg ( 25 °C)
refractive index 
n20/D 1.539(lit.)
Flash point:
131 °F
storage temp. 
Inert atmosphere,Room Temperature
solubility 
2g/l
form 
Powder
color 
Yellow to orange to brown
Water Solubility 
0.2 g/100 mL (25 ºC)
BRN 
115506
InChIKey
FTNJQNQLEGKTGD-UHFFFAOYSA-N
LogP
2.08
CAS DataBase Reference
274-09-9(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Benzodioxole(274-09-9)
EPA Substance Registry System
1,3-Benzodioxole (274-09-9)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/22-22-10-36/37/38-20/21/22-10/22
Safety Statements 
23-24/25-36/37/39-26-16-36
RIDADR 
UN 1993 3/PG 3
WGK Germany 
3
RTECS 
DA5600000
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29329970
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
159166
Product name
1,3-Benzodioxole
Purity
99%
Packaging
50g
Price
$65.9
Updated
2025/07/31
TCI Chemical
Product number
M0658
Product name
1,2-Methylenedioxybenzene
Purity
>99.0%(GC)
Packaging
25mL
Price
$25
Updated
2025/07/31
TCI Chemical
Product number
M0658
Product name
1,2-Methylenedioxybenzene
Purity
>99.0%(GC)
Packaging
100mL
Price
$64
Updated
2025/07/31
TCI Chemical
Product number
M0658
Product name
1,2-Methylenedioxybenzene
Purity
>99.0%(GC)
Packaging
500mL
Price
$198
Updated
2025/07/31
Usbiological
Product number
410941
Product name
1,3-Benzodioxole
Packaging
5g
Price
$305
Updated
2021/12/16
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1,3-Benzodioxole Chemical Properties,Usage,Production

Description

1,3-Benzodioxole, widely found in plant products, has shown potent antioxidant and antibacterial activities. It has recently been reported that 1,3-benzodioxole derivatives possess cytotoxic activity against several human tumor cell lines, including human colon carcinoma cells and multidrug-resistant nasopharyngeal carcinoma cells. No cytotoxic effects were noticed at a concentration of 10-4 M.

Chemical Properties

clear colourless to light yellow liquid. Insoluble in acids.

Uses

1,3-Benzodioxole is useful in gemological stimulant detection. It is also used as a precursor for perfumes, photo initiators, agrochemicals and pharmaceuticals. 1,3-benzodimine is an intermediate for the synthesis of the drugs oxolinic acid, cinoxacin and miloxacin.

Definition

ChEBI: 1,3-benzodioxole is a benzodioxole consisting of a benzene ring substituted by a the methylenedioxy group.

Production Methods

1,3-Benzodioxole is synthesized through the reaction of catechol with dihalomethanes, typically employing a concentrated aqueous alkaline solution in the presence of tetraalkylammonium or phosphonium salts, sometimes in the presence of alkyl iodides. 1,3-Benzodioxole is an important intermediate in organic synthesis, especially for the preparation of alkaloids.

Application

1,3-Benzodioxole belong to methylenedioxyphenyl (MDP) compounds that regulate cytochrome P 450-dependent drug oxidation, which is important in the process of eliminating drugs from the body. a hydrogen abstraction process can take place from the methylene-bridgea carbon of the benzodioxole compound and form a methylenedioxybenzene radical. It is therefore highly likely that 1,3-benzodioxole could serve as hydrogen donor for a CQ-based system initiating the photopolymerization of dental composite resin. In addition, 1,3-benzodioxole is an important organic intermediate (building block) to synthetize substituted methylenedioxybenzene products.

General Description

Supersonic jet fluorescence spectra of 1,3-benzodioxole has been studied. The far-infrared spectrum of the vapour of 1,3-benzodioxole has been reported. The electronic absorption spectra and the laser-induced fluorescence spectra of supersonic-jet-cooled 1,3-benzodioxole molecules has been investigated.

1,3-Benzodioxole Preparation Products And Raw materials

Raw materials

FUMING SULFURIC ACID Ethanol Acetone Calcium chloride Paraformaldehyde Diethyl ether Catechol Dimethyl sulfoxide Sodium hydroxide

Preparation Products

Piperonyl chloride 3,4-METHYLENEDIOXYPHENYL ISOTHIOCYANATE 3,4-(Methylenedioxy)phenylacetonitrile 1,2-(Methylenedioxy)-4-nitrobenzene Piperonyl aldehyde 4-NITROCATECHOL PIPERONYL FORMALDEHYDE Ethyl vanillin
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1,3-Benzodioxole Suppliers

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View Lastest Price from 1,3-Benzodioxole manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
1,3-Benzodioxole 274-09-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-13
Hebei Chuanghai Biotechnology Co., Ltd
Product
1,3-Benzodioxole 274-09-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-30
Henan Aochuang Chemical Co.,Ltd.
Product
1,3-Benzodioxole 274-09-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-14

274-09-9, 1,3-BenzodioxoleRelated Search:

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