ChemicalBook > CAS DataBase List > Pertuzumab
Pertuzumab
- Product Name
- Pertuzumab
- CAS No.
- 380610-27-5
- Chemical Name
- Pertuzumab
- Synonyms
- 2C4;Omnitarg;pertuzumab;Unii-K16aiq8ctm;Pertuzumab-Perjeta;Pertuzumab (anti-HER2);Research Grade Pertuzumab(DHC09602);Immunoglobulin G1, anti-(human V (receptor)) (human-mouse monoclonal 2C4 heavy chain), disulfide with human-mouse monoclonal 2C4 kappa-chain, dimer
- CBNumber
- CB41856062
- Molecular Formula
- C17H27NO2
- Formula Weight
- 277.40178
- MOL File
- 380610-27-5.mol
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Safety
- Hazardous Substances Data
- 380610-27-5(Hazardous Substances Data)
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-7826
- Product name
- Pertuzumab
- Packaging
- 1mg
- Price
- $348
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- BP165593
- Product name
- Pertuzumab
- Packaging
- 1mg
- Price
- $550
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-7826
- Product name
- Pertuzumab
- Packaging
- 5mg
- Price
- $705
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-7826
- Product name
- Pertuzumab
- Packaging
- 25mg
- Price
- $2650
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-7826
- Product name
- Pertuzumab
- Packaging
- 50mg
- Price
- $4250
- Updated
- 2021/12/16
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Pertuzumab Chemical Properties,Usage,Production
Description
Pertuzumab is an anti-human epidermal growth factor receptor 2 (HER2) antibody that was approved by the US FDA in June 2012 for use in combination with trastuzumab (Herceptin?) and docetaxel chemotherapy for the treatment of people with HER2-positive (HER2+) metastatic breast cancer (mBC) who have not received prior anti-HER2 therapy or chemotherapy for metastatic disease. Pertuzumab inhibits HER2 dimer formation with other HER members, such as HER1 and HER3, thus inhibiting the downstream signaling processes associated with tumor growth and progression. Pertuzumab is the first HER2 dimerization inhibitor to reach the market. The mechanism of actions of trastuzumab and pertuzumab are believed to complement each other and provide a more comprehensive inhibition of tumor growth than either agent alone. Preclinical data showed that the combination of trastuzumab and pertuzumab has a strongly enhanced antitumor effect and induces tumor regression in xenograft models, something that cannot be achieved by either monotherapy alone.
Originator
Genentech, a member of the Roche Group (United States)
Uses
Anti-neoplastic.
brand name
Perjeta
Clinical Use
Monoclonal antibody:
Treatment of HER2 receptor +ve breast cancer
Metabolism
Antibodies are cleared mainly by catabolism.
Pertuzumab Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pertuzumab manufacturers
Hangzhou Huarong Pharm Co., Ltd.
- Product
- Pertuzumab 380610-27-5
- Price
- US $0.00-0.00/mg
- Min. Order
- 5mg
- Purity
- 99%
- Supply Ability
- 50KG
- Release date
- 2021-09-15
Career Henan Chemical Co
- Product
- Pertuzumab 380610-27-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-01-02
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