3-BROMO-2,6-DIFLUOROBENZALDEHYDE
- Product Name
- 3-BROMO-2,6-DIFLUOROBENZALDEHYDE
- CAS No.
- 398456-82-1
- Chemical Name
- 3-BROMO-2,6-DIFLUOROBENZALDEHYDE
- Synonyms
- 3-BROMO-2,6-DIFLUOROBENZALDEHYDE;3-Bromo-2,6-difluorobenzaldehyde98%;Benzaldehyde, 3-bromo-2,6-difluoro-;3-Bromo-2,6-difluorobenzaldehyde 98%;3-BROMO-2,6-DIFLUOROBENZALDEHYDE ISO 9001：2015 REACH
- CBNumber
- CB4196011
- Molecular Formula
- C7H3BrF2O
- Formula Weight
- 221
- MOL File
- 398456-82-1.mol
3-BROMO-2,6-DIFLUOROBENZALDEHYDE Property
- Melting point:
- 53-57°C
- Boiling point:
- 223℃
- Density
- 1.758
- Flash point:
- 89℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder
- color
- White
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C7H3BrF2O/c8-5-1-2-6(9)4(3-11)7(5)10/h1-3H
- InChIKey
- OXBHKEYDKAWFLS-UHFFFAOYSA-N
- SMILES
- C(=O)C1=C(F)C=CC(Br)=C1F
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- CDS022691
- Product name
- 3-Bromo-2,6-difluorobenzaldehyde
- Packaging
- 100 mg
- Price
- $36.7
- Updated
- 2025/07/31
- Product number
- B700380
- Product name
- 3-Bromo-2,6-difluorobenzaldehyde
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC7849
- Product name
- 3-Bromo-2,6-difluorobenzaldehyde
- Purity
- 98%
- Packaging
- 5g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- J98036
- Product name
- 3-Bromo-2,6-difluorobenzaldehyde
- Packaging
- 5g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 2615-B-01
- Product name
- 3-Bromo-2,6-difluorobenzaldehyde
- Purity
- 98%
- Packaging
- 5G
- Price
- $47
- Updated
- 2021/12/16
3-BROMO-2,6-DIFLUOROBENZALDEHYDE Chemical Properties,Usage,Production
Uses
3-Bromo-2,6-difluorobenzaldehyde is used as a pharmaceutical intermediate.
Synthesis
348-57-2
68-12-2
398456-82-1
Lithium diisopropylammonium (2M THF solution, 13 mL, 26 mmol) was slowly added dropwise to a solution of anhydrous THF (80 mL) of 1-bromo-2,4-difluorobenzene (5.0 g, 25.9 mmol) at -78 °C, and the reaction was stirred for 1 h at -78 °C maintaining the temperature. Subsequently, N,N-dimethylformamide (2.0 g, 28 mmol) was added to the reaction system and stirring was continued at -78 °C for 30 min. After completion of the reaction, the reaction was quenched by adding water to the reaction mixture and extracted with ethyl acetate. The organic phases were combined, washed sequentially with 1N hydrochloric acid and water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane=1:9) to give 3.0 g of 3-bromo-2,6-difluorobenzaldehyde in 32% yield. The melting point of the product was 53-54 °C. 1H-NMR (CDCl3) δ: 7.00 (1H, dt, J = 9.3,1.8 Hz), 7.71-7.82 (1H, m), 10.3 (1H, s).
References
[1] Patent: US2010/41891, 2010, A1. Location in patent: Page/Page column 62
[2] Patent: WO2015/89809, 2015, A1. Location in patent: Page/Page column 49; 50
[3] Patent: WO2015/95256, 2015, A1. Location in patent: Page/Page column 50
3-BROMO-2,6-DIFLUOROBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-BROMO-2,6-DIFLUOROBENZALDEHYDE manufacturers
- Product
- 3-Bromo-2,6-difluorobenzaldehyde 398456-82-1
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-10-22
- Product
- 3-BROMO-2,6-DIFLUOROBENZALDEHYDE 398456-82-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-02