JNJ-26481585

ChemicalBook > CAS DataBase List > JNJ-26481585

Product Name: JNJ-26481585
CAS No.: 875320-29-9
Chemical Name: JNJ-26481585
Synonyms: CS-1098;Quisinostat;JNJ-26481585;Quisinostat HClbase;JNJ26481585;JNJ 26481585;Quisinostat (JNJ-26481585);Quisinostat (JNJ-26481585) 2HCl;JNJ-26481585 JNJ26481585 Quisinostat;N1-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diaMine;N-Hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)-methyl)piperidin-1-yl)pyrimidine-5-car
CBNumber: CB42500942
Molecular Formula: C21H26N6O2
Formula Weight: 394.47
MOL File: 875320-29-9.mol

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JNJ-26481585 Property

Density: 1.35
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥19.2 mg/mL in DMSO
form: Powder

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 14088
Product name: JNJ-26481585
Purity: ≥98%
Packaging: 1mg
Price: $71
Updated: 2022/04/27

Cayman Chemical

Product number: 14088
Product name: JNJ-26481585
Purity: ≥98%
Packaging: 5mg
Price: $177
Updated: 2022/04/27

Cayman Chemical

Product number: 14088
Product name: JNJ-26481585
Purity: ≥98%
Packaging: 10mg
Price: $317
Updated: 2022/04/27

Cayman Chemical

Product number: 14088
Product name: JNJ-26481585
Purity: ≥98%
Packaging: 50mg
Price: $703
Updated: 2022/04/27

TRC

Product number: J211333
Product name: JNJ-26481585
Packaging: 5mg
Price: $275
Updated: 2021/12/16

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JNJ-26481585 Chemical Properties,Usage,Production

Uses

JNJ-26481585 is an HDAC1, HDAC2, HDAC4, HDAC10, and HDAC11 inhibitor. Potent Histone deacetylase inhibitor.

Definition

ChEBI: N-hydroxy-2-[4-[[(1-methyl-3-indolyl)methylamino]methyl]-1-piperidinyl]-5-pyrimidinecarboxamide is a member of indoles.

Biological Activity

jnj-26481585 is a novel histone deacetylase (hdac) inhibitor that exerts a strong potency towards class i hdac (including hdac1, hdac2 and hdac3), with values of inhibition constant ic50 of 0.11, 0.33 and 4.8 nmol/l respectively, leading to strong anti-proliferative activities (ic50 ranging from 3.1 to 246 nmol/l) against a broad range of cancer cell lines including lung, breast, colon, prostate, brain and overian cancer cell lines. recent study results have shown that jnj-26481585 strongly induce the hdac1-suppressed p21waf1,cip1 promoter in vivo, histone h3 acetylation in tumor tissue and apoptosis in human colon cancer cell lines (both apc wild-type and mutant) in vitro.arts j, king p, mariën a, floren w, beliën a, janssen l, pilatte i, roux b, decrane l, gilissen r, hickson i, vreys v, cox e, bol k, talloen w, goris i, andries l, du jardin m, janicot m, page m, van emelen k, angibaud p. jnj-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity. clin cancer res. 2009;15(22):6841-6851

target

HDAC1

JNJ-26481585 Preparation Products And Raw materials

Raw materials

Preparation Products

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875320-29-9, JNJ-26481585Related Search:

JNJ0966 JNJ-38158471 N-[2-(1H-Indol-3-yl)ethyl]-N'-(4-pyridinyl)-1,4-benzenediamine TRC253 3-(cyclopropylMethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoroMethyl)-[1,2,4]triazolo[4,3-a]pyridine JNJ-7706621 JNJ 63533054 N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide JNJ 31020028 JNJ-10229570 JNJ-632 2-(4-Chlorophenoxy)-2-methyl-N-[5-[(methylsulfonyl)amino]tricyclo[3.3.1.13,7]dec-2-yl]-propanamide TRICHOSTATIN A Panobinostat Mocetinostat (MGCD0103) Vorinostat (1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone CRA-02478

JNJ-26481585

N1-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diaMine

N-Hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-5-pyrimidinecarboxamide

N-Hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)-methyl)piperidin-1-yl)pyrimidine-5-carbox

N-Hydroxy-2-(4-((((1-Methyl-1H-indol-3-yl)Methyl)aMino)Methyl)piperidin-1-yl)pyriMidine-5-carboxaMide

Quisinostat (JNJ-26481585)

Quisinostat

N-Hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)-methyl)piperidin-1-yl)pyrimidine-5-car

Quisinostat (JNJ-26481585) 2HCl

CS-1098

JNJ26481585;JNJ 26481585

N-hydroxy-2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]pyrimidine-5-carboxamide

Quisinostat HClbase

5-Pyrimidinecarboxamide, N-hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-

JNJ-26481585 JNJ26481585 Quisinostat

875320-29-9

Inhibitors

Inhibitor