ChemicalBook > CAS DataBase List > OSI-027

OSI-027

Product Name
OSI-027
CAS No.
936890-98-1
Chemical Name
OSI-027
Synonyms
CS-436;OSI-027;ASP4786;CPD2801;OSI-027, >=98%;OSI027;OSI 027;OSI-027 USP/EP/BP;OSI-027;OSI 027;ASP4786;trans-4-[4-Amino-5-(7-methoxy-1H-i;OSI-027 (ASP-4786, CERC-006, AEVI-006)
CBNumber
CB42538725
Molecular Formula
C21H22N6O3
Formula Weight
406.44
MOL File
936890-98-1.mol
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OSI-027 Property

Melting point:
>149°C (subl.)
Density 
1.59
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly)
pka
4.44±0.10(Predicted)
form 
Solid
color 
Pale Beige to Light Beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17379
Product name
OSI-027
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
17379
Product name
OSI-027
Purity
≥98%
Packaging
5mg
Price
$134
Updated
2024/03/01
Cayman Chemical
Product number
17379
Product name
OSI-027
Purity
≥98%
Packaging
10mg
Price
$249
Updated
2024/03/01
Cayman Chemical
Product number
17379
Product name
OSI-027
Purity
≥98%
Packaging
50mg
Price
$670
Updated
2024/03/01
TRC
Product number
A611910
Product name
4-(4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]Triazin-7-yl)cyclohexanecarboxylicAcid
Packaging
1mg
Price
$65
Updated
2021/12/16
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OSI-027 Chemical Properties,Usage,Production

Description

The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin ) and regulate different pathways. OSI-027 is an inhibitor of the catalytic site of mTOR and, as a result, inhibits both mTORC1 and mTORC2 (IC50s = 22 and 65 nM, respectively). It is selective for mTOR over phosphatidylinositol 3-kinase isoforms and DNA protein kinase. OSI-027 prohibits proliferation, induces autophagy, and potentiates apoptosis in BCR-ABL transformed cells and other cancer cells at 10 μM. OSI-027 is effective in vivo, blocking the phosphorylation of targets of mTORC1 and mTORC2 and suppressing tumor growth in several different human xenograft models.

Uses

OSI-027 is a kinase inhibitor with anti-tumor activity, used in treatment of breast cancer.

Definition

ChEBI: 4-[4-amino-5-(7-methoxy-2-indolylidene)-1H-imidazo[5,1-f][1,2,4]triazin-7-yl]-1-cyclohexanecarboxylic acid is a member of indoles.

target

mTORC

References

[1] bhagwat s v, gokhale p c, crew a p, et al. preclinical characterization of osi-027, a potent and selective inhibitor of mtorc1 and mtorc2: distinct from rapamycin. molecular cancer therapeutics, 2011, 10(8): 1394-1406.

OSI-027 Preparation Products And Raw materials

Raw materials

Preparation Products

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OSI-027 Suppliers

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View Lastest Price from OSI-027 manufacturers

Career Henan Chemical Co
Product
OSI-027 936890-98-1
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
ask
Release date
2018-12-23

936890-98-1, OSI-027Related Search:

3'-Amino-4'-methoxyacetanilide p-Anisidine-3-sulfonic acid trans-4-Aminocyclohexanol AZD-8055 VE 822 Ibrutinib LY 294002 HYDROCHLORIDE Rapamycin BEZ235 (NVP-BEZ235, Dactolisib)

  • OSI-027
  • trans-4-[4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexanecarboxylic acid
  • 4-(4-aMino-5-(7-Methoxy-1H-indol-2-yl)-1,2-dihydroiMidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid hydrochloride
  • 4-(4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f] [1,2,4]Triazin-7-yl)cyclohexanecarboxylic Acid
  • (1r,4r)-4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[1,5-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid
  • ASP4786
  • OSI-027 trans-4-[4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexanecarboxylic acid
  • trans-4-[4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexanecarboxylic acid OSI-027
  • OSI-027, >=98%
  • CYCLOHEXANECARBOXYLIC ACID, 4-[4-AMINO-5-(7-METHOXY-1H-INDOL-2-YL)IMIDAZO[5,1-F][1,2,4]TRIAZIN-7-YL]-, TRANS-
  • trans-4-[4-Amino-5-(7-methoxy-1H-i
  • (1r,4r)-4-(4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo-[5,1-f][1,2,4]triazin-7-yl)cyclohexaneca
  • OSI-027;OSI 027;ASP4786
  • CS-436
  • CPD2801
  • OSI027;OSI 027
  • OSI-027 USP/EP/BP
  • OSI-027 (ASP-4786, CERC-006, AEVI-006)
  • 936890-98-1
  • Akt
  • mTOR
  • PI3K
  • Inhibitors