OSI-027
- Product Name
- OSI-027
- CAS No.
- 936890-98-1
- Chemical Name
- OSI-027
- Synonyms
- CS-436;OSI-027;ASP4786;CPD2801;OSI-027, >=98%;OSI027;OSI 027;OSI-027 USP/EP/BP;OSI-027;OSI 027;ASP4786;trans-4-[4-Amino-5-(7-methoxy-1H-i;OSI-027 (ASP-4786, CERC-006, AEVI-006)
- CBNumber
- CB42538725
- Molecular Formula
- C21H22N6O3
- Formula Weight
- 406.44
- MOL File
- 936890-98-1.mol
OSI-027 Property
- Melting point:
- >149°C (subl.)
- Density
- 1.59
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly)
- pka
- 4.44±0.10(Predicted)
- form
- Solid
- color
- Pale Beige to Light Beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 17379
- Product name
- OSI-027
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 17379
- Product name
- OSI-027
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $134
- Updated
- 2024/03/01
- Product number
- 17379
- Product name
- OSI-027
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $249
- Updated
- 2024/03/01
- Product number
- 17379
- Product name
- OSI-027
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $670
- Updated
- 2024/03/01
- Product number
- A611910
- Product name
- 4-(4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]Triazin-7-yl)cyclohexanecarboxylicAcid
- Packaging
- 1mg
- Price
- $65
- Updated
- 2021/12/16
OSI-027 Chemical Properties,Usage,Production
Description
The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin ) and regulate different pathways. OSI-027 is an inhibitor of the catalytic site of mTOR and, as a result, inhibits both mTORC1 and mTORC2 (IC50s = 22 and 65 nM, respectively). It is selective for mTOR over phosphatidylinositol 3-kinase isoforms and DNA protein kinase. OSI-027 prohibits proliferation, induces autophagy, and potentiates apoptosis in BCR-ABL transformed cells and other cancer cells at 10 μM. OSI-027 is effective in vivo, blocking the phosphorylation of targets of mTORC1 and mTORC2 and suppressing tumor growth in several different human xenograft models.
Uses
OSI-027 is a kinase inhibitor with anti-tumor activity, used in treatment of breast cancer.
Definition
ChEBI: 4-[4-amino-5-(7-methoxy-2-indolylidene)-1H-imidazo[5,1-f][1,2,4]triazin-7-yl]-1-cyclohexanecarboxylic acid is a member of indoles.
target
mTORC
References
[1] bhagwat s v, gokhale p c, crew a p, et al. preclinical characterization of osi-027, a potent and selective inhibitor of mtorc1 and mtorc2: distinct from rapamycin. molecular cancer therapeutics, 2011, 10(8): 1394-1406.
OSI-027 Preparation Products And Raw materials
Raw materials
Preparation Products
OSI-027 Suppliers
View Lastest Price from OSI-027 manufacturers
- Product
- OSI-027 936890-98-1
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- ask
- Release date
- 2018-12-23